A Randomized, Participant-Masked, Crossover Study Evaluating Postprandial Glycemic Response to Three Sweetener Preloads Consumed Before a Standardized Mixed Meal in Healthy Adults
Sponsor study identifier
interventional
50
0 countries
N/A
Study Start
December 1, 2026
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Primary Completion
January 15, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
May 1, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
This study is using a double-blind, randomize crossover evaluating the impact of three different sweeteners on postprandial glycemic response in a mixed meal setting. In 50 individuals, postprandial glucose response will be evaluated as a primary objective. Secondary objectives include additional measures of glucose response as well general gastrointestinal response to the sweeteners, assessed through a series of questionnaires.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
May 1, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
October 19, 2026
Actual (reported)October 26, 2026
Actual (reported)December 1, 2026
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
January 15, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
May 1, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Postprandial Area Under the Curve to 120 Minutes
Area under the curve above baseline from time zero (the start of the preload consumption) through 120 minutes. Baseline is defined as the mean glucose over the 15 minutes prior to the preload consumption. Area falling below baseline will be excluded.
Data will be collected on each day of supplementation, days 3, 4, 6, 7, 9, and 10.
Postprandial Area Under the Curve to 180 Minutes
Data will be collected on each day of supplementation, days 3, 4, 6, 7, 9, and 10.
Postprandial Area Under the Curve to 120 Minutes Relative to Start of the Meal
Data will be collected on each day of supplementation, days 3, 4, 6, 7, 9, and 10.
Peak Glucose
Data will be collected on each day of supplementation, days 3, 4, 6, 7, 9, and 10.
Incremental Peak Glucose
Data will be collected on each day of supplementation, days 3, 4, 6, 7, 9, and 10.
Time to Peak
Data will be collected on each day of supplementation, days 3, 4, 6, 7, 9, and 10.
Sugar, stevia, and a fiber-based alternative sweetener will be evaluated in a pre-defined order.
Sugar, stevia, and a fiber-based alternative sweetener will be evaluated in a pre-defined order.
A fiber-based sweetener produced by LOAM.
First Submitted
October 19, 2026
First Posted
October 26, 2026
Study Start
December 1, 2026
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Sugar, stevia, and a fiber-based alternative sweetener will be evaluated in a pre-defined order.
Sugar, stevia, and a fiber-based alternative sweetener will be evaluated in a pre-defined order.
Sugar, stevia, and a fiber-based alternative sweetener will be evaluated in a pre-defined order.
Sugar, stevia, and a fiber-based alternative sweetener will be evaluated in a pre-defined order.
Table sugar
Contact the study team to confirm eligibility.
Primary Completion
January 15, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
May 1, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Last Updated
October 26, 2026
Record last verified: 2026-10
IPD is proprietary information.
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