The Effect of Sugar Load in IBS Patients Depending on Sucrase-isomaltase Genes

NCT05688826 | Completed

• 1 other identifier: Sugarload-2023
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

The investigators know that many patients with irritable bowel syndrome (IBS) have functional variants of genes coding for sucrase-isomaltase enzymes. The investigators will now examine whether these functional variants are associated with defect degradation of sucrose and associated gastrointestinal symptoms

Conditions

Sucrase-Isomaltase Deficiency; Irritable Bowel Syndrome

Keywords

gastrointestinal symptoms, glucose

Outcome Measures

Primary Outcomes (2)

• Changes from baseline of blood glucose levels

  Measurement of glucose levels in blood drawn from an intravenous needle and analyzed at the Department of Clinical Chemostry

  From distribution repeatedly up to 2 hours

• Change from baseline of gastrointestinal symptoms

  Measurment of gastrointestinal symptoms on a visual analog scale measuring symptoms, range 0-100 mm, repeatedly at the same time points as blood glucose is measured. The higher scores, the worse symptoms.

  From baseline and up to 2 hours, at the same time points as blood glucose is measured

Study Arms (1)

Sugar load

EXPERIMENTAL

Sugar dissolved in water will be ingested during 5 minutes

Dietary Supplement: Sugar

Interventions

Sugar DIETARY_SUPPLEMENT

75 g sugar dissolved in 0.8 dl water and flavored with lemon. Ingested during 5 minutes

Sugar load

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Participants of our previous clinical trial with SSRD diet (NCT03306381)

You may not qualify if:

• Difficulties in taking blood samples

Sponsors & Collaborators

• Region Skane: lead

Study Sites (1)

Department of Internal Medicine, Skåne University Hospital

Malmo, 20502, Sweden

Location

MeSH Terms

Conditions

Sucrase-isomaltase deficiency, congenital; Irritable Bowel Syndrome

Interventions

Sugars

Condition Hierarchy (Ancestors)

Colonic Diseases, Functional; Colonic Diseases; Intestinal Diseases; Gastrointestinal Diseases; Digestive System Diseases

Intervention Hierarchy (Ancestors)

Carbohydrates

Study Officials

• Cecilia Kennback, Nurse

  Department of Internal Medicine, Skåne University Hospital, Malmö

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Model Details: Patients with normal genes and with functional variants of sucrase-isomaltase genes

Study Record Dates

• First Submitted: January 9, 2023
• First Posted: January 18, 2023
• Study Start: January 4, 2023
• Primary Completion: September 27, 2023
• Study Completion: June 23, 2025
• Last Updated: June 27, 2025

Record last verified: 2025-06

Data Sharing

• IPD Sharing: Will not share

Locations

SE (1)