Effect of Circadian Timing of a Standardized Meal on Postprandial Glucose Response in Healthy Adults

NCT07545330 | Not Yet Recruiting DMC

• 1 other identifier: ETHICS3992
• Study Type: interventional
• Target: 32
• Locations: 1 country
• Sites: 1

Brief Summary

This randomized crossover study aims to investigate the effect of circadian timing of a standardized meal (morning versus evening consumption) on postprandial glucose response in healthy adults. Postprandial glucose will be assessed using the incremental area under the curve (iAUC) over 120 minutes.

Conditions

Meal Timing; Postprandial Glucose; Glycemic Response to Feeding in Healthy Participants

Outcome Measures

Primary Outcomes (1)

• Incremental Area Under the Curve (iAUC) for Postprandial Glucose

  The primary objective of this study is to investigate the effect of circadian timing of a standardized test meal (morning versus evening consumption) on postprandial glucose response in healthy adults, assessed as the incremental area under the curve (iAUC) for capillary blood glucose over 120 minutes following meal consumption

  Baseline to 120 minutes after consumption of the standardized test meal

Secondary Outcomes (3)

• Peak Postprandial Glucose (Morning vs Evening)

  Baseline to 120 minutes after consumption of the standardized test meal

• Time to Peak Glucose (Morning vs Evening)

  Baseline to 120 minutes after consumption of the standardized test meal

• Postprandial Glucose Profile (Morning vs Evening)

  Baseline, 15, 30, 60, 90, and 120 minutes after consumption of the standardized test meal

Other Outcomes (3)

• Night Eating Behavior

  Baseline

• Sleep Duration and Quality

  Baseline

• Chronotype

  Baseline

Study Arms (2)

Morning Meal Condition

EXPERIMENTAL

Participants will consume a standardized test meal in the morning following an overnight fasting period of at least 8 hours. Postprandial glucose will be measured over 120 minutes.

Other: Standardized Test Meal

Evening Meal Condition

EXPERIMENTAL

Participants will consume the same standardized test meal in the evening following a standardized fasting period of at least 8 hours prior to the test meal. Postprandial glucose will be measured over 120 minutes.

Other: Standardized Test Meal

Interventions

Standardized Test Meal OTHER

The standardized test meal provided 50 g of carbohydrates of weighed portions of white bread and jam, served with 200 mL of water.

Evening Meal Condition; Morning Meal Condition

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Healthy adults aged 18 years and older
• Able and willing to provide informed consent
• Able to comply with study procedures

You may not qualify if:

• Diagnosis of diabetes or any metabolic disorder affecting glucose regulation
• Use of any medications
• Pregnant or breastfeeding women
• Night shift workers or individuals with irregular sleep patterns

Sponsors & Collaborators

• King Faisal University: lead
• Saudi Food and Drug Authority: collaborator

Study Sites (1)

King Faisal University

Al-Ahsa, Eastern Province, 31982, Saudi Arabia

Location

Central Study Contacts

Wafa Alotaibi, PhD

CONTACT

+966500358622; Walotaibi@kfu.edu.sa

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 16, 2026
• First Posted: April 22, 2026
• Study Start: April 15, 2026
• Primary Completion (Estimated): May 30, 2026
• Study Completion (Estimated): May 30, 2026
• Last Updated: April 22, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will not share

Locations

SA (1)