Trials Sponsors Conditions Drugs Pricing

Conditions

Mastectomy Mastectomy Plus Axillary Lymph Node Dissection Nerve Block; Pain Medication Opioid Analgesic Adverse Reaction Opioid Consumption Pectoralis Nerve Block Serratus Anterior Muscle Plane Block

Keywords

MastectomyBreast cancerPECS II blockPectoralis nerves blockSerratus anterior plane blockCombined regional blocksUltrasound-guided regional anesthesiaAcute postoperative painOpioid consumptionOpioid-sparing analgesia

Outcome Measures

Primary Outcomes (1)

Cumulative perioperative opioid consumption till 24 hours postop
Total opioid administered intraoperatively and during the first 24 hours after surgery, including PACU rescue morphine and morphine delivered through patient-controlled analgesia. Consumption will be obtained from anesthesia intraoperative recirds, PACU medication records, and PCA logs.
From start of surgery till 24 hours postop; cumulative consumption postop will be recorded at 1, 2, 4, 6, 12, 18, and 24 hours.

Study Arms (2)

PECS II Block Alone

ACTIVE COMPARATOR

Participants will receive PECS II alone before general anesthesia, with standardized perioperative multimodal analgesia and postoperative morphine patient-controlled analgesia and non-opioid pain medications.

Procedure: Pectoral nerve block (PECS)

PECS II Block Plus Serratus Anterior Plane Block SAPB

EXPERIMENTAL

Participants will receive PECS II combined with a deep serratus anterior plane block before general anesthesia. General anesthesia and perioperative and postoperative analgesia will be standardized as in the active comparator arm.

Procedure: Serratus Anterior Plane Block (SAPB) groupProcedure: Pectoral nerve block (PECS)

Interventions

Serratus Anterior Plane Block (SAPB) groupProcedure

An experienced anesthesiologist will perform a single deep serratus anterior plane block before induction of general anesthesia under ultrasound guidance and aseptic conditions, injecting 15-20 mL of ropivacaine 0.375%, adjusted according to body weight, into the plane deep to the serratus anterior muscle. The total ropivacaine dose across both blocks will not exceed 3 mg/kg.

PECS II Block Plus Serratus Anterior Plane Block SAPB

Pectoral nerve block (PECS)Procedure

Eligibility Criteria

Age18 Years+

Sexfemale

Healthy VolunteersNo

Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

Female patients aged 18 years or older
ASA physical status I-III

Sponsors & Collaborators

Lebanese American University
Otherlead
Lebanese American University Medical Center
Othercollaborator

Study Sites (1)

Lebanese American University Medical Center-Rizk Hospital

Beirut, Lebanon

MeSH Terms

Conditions

Breast NeoplasmsPain, Postoperative

Interventions

SaposinsPopulation Groups

Condition Hierarchy (Ancestors)

Neoplasms by SiteNeoplasmsBreast DiseasesSkin DiseasesSkin and Connective Tissue DiseasesPostoperative ComplicationsPathologic ProcessesPathological Conditions, Signs and SymptomsPainNeurologic Manifestations

Central Study Contacts

Hanane Barakat, MD

CONTACT

+9613612009 hanane.barakat@lau.edu.lb

Study Design

Study Type: interventional
Phase: not applicable
Allocation: RANDOMIZED
Masking: TRIPLE
Who Masked: PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
Purpose: TREATMENT
Intervention Model: PARALLEL
Sponsor Type: OTHER
Responsible Party: PRINCIPAL INVESTIGATOR
PI Title: Clinical associate professor of anesthesiology

Study Record Dates

First Submitted

October 12, 2026

First Posted

October 19, 2026

Study Start

December 2026

Estimated

Planned date reported by the registry; this milestone is not confirmed as achieved.

Primary Completion

Effect of Serratus and Pectoralis II Plane Block Versus Pectoralis II Alone on Acute Postoperative Pain After Mastectomy

Brief Summary

Registry Overview

Trial Relationships

Study Timeline

First Submitted

First Posted

Study Start

Primary Completion

Study Completion

Conditions

Keywords

Outcome Measures

Primary Outcomes (1)

Study Arms (2)

PECS II Block Alone

PECS II Block Plus Serratus Anterior Plane Block SAPB

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

MeSH Terms

Conditions

Interventions

Condition Hierarchy (Ancestors)

Central Study Contacts

Study Design

Study Record Dates

You may not qualify if:

Intervention Hierarchy (Ancestors)

Data Sharing

Source record

Locations

Effect of Serratus and Pectoralis II Plane Block Versus Pectoralis II Alone on Acute Postoperative Pain After Mastectomy

Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

First Submitted

First Posted

Study Start

Primary Completion

Study Completion

Conditions

Keywords

Outcome Measures

Primary Outcomes (1)

Study Arms (2)

PECS II Block Alone

PECS II Block Plus Serratus Anterior Plane Block SAPB

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

MeSH Terms

Conditions

Interventions

Condition Hierarchy (Ancestors)

Central Study Contacts

Study Design

Study Record Dates

You may not qualify if:

Intervention Hierarchy (Ancestors)

Data Sharing

Source record

Locations