Effect of Curcumin Topical Spray on Wound Healing After Tooth Extraction

NCT07874789 | Recruiting DMC

• 1 other identifier: 2025//82
• Study Type: interventional
• Target: 54
• Locations: 1 country
• Sites: 1

Brief Summary

This randomized, single-blind, controlled clinical trial aims to evaluate the effects of a topical curcumin spray on post-extraction wound healing and postoperative symptoms in adults undergoing first molar extraction. Participants will be randomly assigned to one of three groups: curcumin topical spray, 0.12% chlorhexidine topical spray, or standard postoperative care without a topical spray. The interventions will be applied twice daily for 7 days. Postoperative pain will be assessed using a visual analog scale, while wound healing will be evaluated using the Landry, Turnbull, and Howley Healing Index. Wound dimensions will also be recorded during follow-up. In addition, salivary levels of inflammatory biomarkers, including interleukin-1β (IL-1β), tumor necrosis factor-alpha (TNF-α), and prostaglandin E2 (PGE2), will be analyzed to assess the local inflammatory response during the postoperative healing period.The study aims to compare the clinical effects of topical curcumin with chlorhexidine and standard postoperative care during the early healing period after tooth extraction.

Conditions

Wound Healing; Alveolitis of Jaw; Tooth Extraction; Curcumin

Keywords

curcumin; Curcuma longa; Tooth extraction; Wound healing; Postoperative Pain; Chlorhexidine; Oral Wound Healing; Inflammation; Salivary Biomarkers; PGE2; IL-1β; TNF-α

Outcome Measures

Primary Outcomes (1)

• Extraction Socket Healing Assessed Using the Landry, Turnbull and Howley Healing Index

  Extraction socket healing will be assessed using the Landry, Turnbull and Howley Healing Index, ranging from 1 (very poor healing) to 5 (excellent healing). Higher scores indicate better wound healing. Scores will be compared among the curcumin spray, chlorhexidine spray, and standard postoperative care groups.

  postoperative 7. and 14. days

Secondary Outcomes (5)

• Postoperative Pain Intensity

  Postoperative days 1, 3, 5, and 7.

• Change in Extraction Socket Wound Size

  Day 0 following extraction and postoperative days 7 and 14.

• Change in Salivary Interleukin-1 Beta Concentration

  Before extraction (day 0) and postoperative days 2 and 7.

• Change in Salivary Tumor Necrosis Factor Alpha Concentration

  Before extraction (day 0) and postoperative days 2 and 7.

• Change in Salivary Prostaglandin E2 Concentration

  Before extraction (day 0) and postoperative days 2 and 7.

Study Arms (3)

Curcumin Topical Spray

EXPERIMENTAL

Participants will receive a Curcuma longa-containing topical spray applied to the extraction site as two sprays twice daily for 7 days, in addition to standard postoperative care.

Dietary Supplement: Curcumin Topical Spray

Chlorhexidine Topical Spray

ACTIVE COMPARATOR

Participants will receive a 0.12% chlorhexidine topical spray applied to the extraction site as two sprays twice daily for 7 days, in addition to standard postoperative care.

Drug: Chlorhexidine Topical Spray

Standard Postoperative Care

NO INTERVENTION

Participants will receive standard postoperative care following tooth extraction without the use of an additional topical spray.

Interventions

Curcumin Topical Spray DIETARY_SUPPLEMENT

A commercially available Curcuma longa-containing topical spray (Minerelax®) will be applied directly to the extraction site as two sprays twice daily for 7 days following tooth extraction, in addition to standardized postoperative care.

Curcumin Topical Spray

Chlorhexidine Topical Spray DRUG

0.12% chlorhexidine topical spray administered to the extraction site as two sprays twice daily for 7 days.

Also known as: Chlorhexidine 0.12% Topical Spray

Chlorhexidine Topical Spray

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Healthy individuals aged 18-40 years with ASA physical status I.
• Patients scheduled for extraction of a mandibular first molar.
• Individuals who voluntarily agree to participate and provide written informed consent.
• Individuals without chronic systemic disease and who do not use regular medication.
• Patients with no oral health condition that would contraindicate the surgical procedure.

You may not qualify if:

• Pregnant or breastfeeding individuals.
• Patients with systemic diseases or immunosuppression.
• Individuals with a history of previous surgery or trauma in the same region.
• Individuals with a known allergy or hypersensitivity to turmeric (curcumin), chlorhexidine spray, or any component of the study products.
• Individuals who smoke or consume alcohol.
• Individuals who regularly use medications, particularly anti-inflammatory or anticoagulant drugs.

Sponsors & Collaborators

• Istanbul University: lead

Study Sites (1)

Istanbul University Faculty of Dentistry, Department of Oral and Maxillofacial Surgery

Istanbul, Istanbul, 34452, Turkey (Türkiye)

RECRUITING

Related Publications (9)

• Dei Cas M, Ghidoni R. Dietary Curcumin: Correlation between Bioavailability and Health Potential. Nutrients. 2019 Sep 8;11(9):2147. doi: 10.3390/nu11092147.

  PMID: 31500361 RESULT

• Amaliya A, Ramadhanti R, Hadikrishna I, Maulina T. The Effectiveness of 0.2% Chlorhexidine Gel on Early Wound Healing after Tooth Extraction: A Randomized Controlled Trial. Eur J Dent. 2022 Jul;16(3):688-694. doi: 10.1055/s-0041-1739544. Epub 2022 Jan 11.

  PMID: 35016228 RESULT

• Broers DLM, Dubois L, de Lange J, Su N, de Jongh A. Reasons for Tooth Removal in Adults: A Systematic Review. Int Dent J. 2022 Feb;72(1):52-57. doi: 10.1016/j.identj.2021.01.011. Epub 2021 Feb 26.

  PMID: 33648772 RESULT

• Sahebkar A, Henrotin Y. Analgesic Efficacy and Safety of Curcuminoids in Clinical Practice: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Pain Med. 2016 Jun;17(6):1192-202. doi: 10.1093/pm/pnv024. Epub 2015 Dec 14.

  PMID: 26814259 RESULT

• Seyedzadeh MH, Safari Z, Zare A, Gholizadeh Navashenaq J, Razavi SA, Kardar GA, Khorramizadeh MR. Study of curcumin immunomodulatory effects on reactive astrocyte cell function. Int Immunopharmacol. 2014 Sep;22(1):230-5. doi: 10.1016/j.intimp.2014.06.035. Epub 2014 Jul 3.

  PMID: 24998635 RESULT

• Anthwal A, Thakur BK, Rawat MS, Rawat DS, Tyagi AK, Aggarwal BB. Synthesis, characterization and in vitro anticancer activity of C-5 curcumin analogues with potential to inhibit TNF-alpha-induced NF-kappaB activation. Biomed Res Int. 2014;2014:524161. doi: 10.1155/2014/524161. Epub 2014 Jul 24.

  PMID: 25157362 RESULT

• Esatbeyoglu T, Huebbe P, Ernst IM, Chin D, Wagner AE, Rimbach G. Curcumin--from molecule to biological function. Angew Chem Int Ed Engl. 2012 May 29;51(22):5308-32. doi: 10.1002/anie.201107724. Epub 2012 May 4.

  PMID: 22566109 RESULT

• McCoy LC, Wehler CJ, Rich SE, Garcia RI, Miller DR, Jones JA. Adverse events associated with chlorhexidine use: results from the Department of Veterans Affairs Dental Diabetes Study. J Am Dent Assoc. 2008 Feb;139(2):178-83. doi: 10.14219/jada.archive.2008.0134.

  PMID: 18245686 RESULT

• Yin Y, Shuai F, Liu X, Zhao Y, Han X, Zhao H. Biomaterials and therapeutic strategies designed for tooth extraction socket healing. Biomaterials. 2025 May;316:122975. doi: 10.1016/j.biomaterials.2024.122975. Epub 2024 Nov 29.

  PMID: 39626339 RESULT

MeSH Terms

Conditions

Dry Socket; Pain, Postoperative; Inflammation

Interventions

Chlorhexidine

Condition Hierarchy (Ancestors)

Mouth Diseases; Stomatognathic Diseases; Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Pain; Neurologic Manifestations; Signs and Symptoms

Intervention Hierarchy (Ancestors)

Biguanides; Guanidines; Amidines; Organic Chemicals

Study Officials

• Metin Berk Kasapoglu, associate professor

  Istanbul University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Ece Duru

CONTACT

+905314066610; duru.ece@ogr.iu.edu.tr

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Dt.

Model Details: Eligible participants will be randomly allocated in a 1:1:1 ratio to three parallel intervention groups: curcumin topical spray, 0.12% chlorhexidine topical spray, or standard postoperative care. Each participant will receive only the intervention assigned to their group throughout the study period

Study Record Dates

• First Submitted: October 8, 2026
• First Posted: October 15, 2026
• Study Start: September 29, 2026
• Primary Completion (Estimated): November 30, 2026
• Study Completion (Estimated): January 25, 2027
• Last Updated: October 15, 2026

Record last verified: 2026-10

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)