Effect of Injectable Platelet Rich Fibrin (i-PRF) on Extraction Socket Healing: A Split-Mouth Randomized Study.

NCT07257328 | Completed

• 1 other identifier: 22-104
• Study Type: interventional
• Target: 32
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study is to compare extraction socket healing (SH) following surgical extraction of lower third molars (LTMs) with and without the application of injectable platelet rich fibrine (i-PRF). A minimum of 32 participants will be included. One mandibular third molar per participant will be randomly assigned to the control group and the contralateral tooth to the test group. SH, gingival recession, and distal periodontal pocket depth of the adjacent second molar will be assessed, and outcomes compared between sides.

Conditions

Wound Healing; Tooth Extraction Site Healing

Keywords

lower third molars; socket healing; i-PRF

Outcome Measures

Primary Outcomes (1)

• Evaluation of socket healing

  Socket healing of the extracted tooth will be evaluated by using IPR scale which allows to evaluate the healing process according to its biological phases.

  6 weeks

Study Arms (2)

Control group

PLACEBO COMPARATOR

In the control group, routine surgical extraction will be performed, and the extraction socket will be irrigated with 0.9% physiological saline.

Procedure: Surgical extraction of lower third molars.

Test group

EXPERIMENTAL

In the test group, routine surgical extraction will be performed, and the extraction socket will be irrigated with i-PRF.

Procedure: Surgical extraction of lower third molars.

Interventions

Surgical extraction of lower third molars. PROCEDURE

Surgical extraction of lower third molars: Impacted or difficult-to-remove lower wisdom teeth are removed using surgical techniques, involving an incision in the soft tissue and removal of bone.

Control group; Test group

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Individuals of both sexes Age over 18 years Non-smokers Systemically healthy (ASA I) Requiring surgical extraction of bilateral mandibular third molars

You may not qualify if:

• Lack of consent to participate Pregnancy Smokers

Sponsors & Collaborators

• Saglik Bilimleri Universitesi: lead

Study Sites (1)

University of Health Sciences

Istanbul, Turkey (Türkiye)

Location

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Masking Details: The investigators who performed clinical measurements were not involved in the operation and were blinded as to which treatment group the tooth was assigned.
• Purpose: SUPPORTIVE CARE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: To reduce inter-individual variability and minimize bias in estimating the treatment effect, the study was designed as a split-mouth trial, with the two treatments randomly assigned to either the right or left side of the dentition.

Study Record Dates

• First Submitted: November 20, 2025
• First Posted: December 2, 2025
• Study Start: May 1, 2024
• Primary Completion: July 1, 2024
• Study Completion: July 31, 2024
• Last Updated: December 2, 2025

Record last verified: 2023-07

Locations

TU (1)