St. John's Wort Oil for Wound Healing and Pain After Cesarean Section

NCT07012278 | Recruiting

• 1 other identifier: BARU-EBE-GA-02
• Study Type: interventional
• Target: 80
• Locations: 1 country
• Sites: 1

Brief Summary

Cesarean section refers to the surgical procedure in which the fetus is delivered via an incision, typically performed when vaginal delivery is not possible due to high-risk conditions. In recent years, the rate of cesarean deliveries has increased significantly. The quality of treatment and care is crucial in ensuring proper surgical wound healing following cesarean birth. Various new methods and products have been developed for wound healing and care in recent years, some of which are derived from herbal sources. The limitations of pharmacological methods used in the postpartum period, such as treatment failure, concerns about potential harm to the mother and infant, adverse side effects, negative impact on breastfeeding, emergence of resistant microorganisms, and ineffectiveness of current antibiotics, have led individuals to seek alternative natural remedies. Hypericum perforatum (commonly known as St. John's Wort) is frequently used in the postpartum period due to its antimicrobial and antioxidant properties. This study aims to examine the effects of Hypericum perforatum on wound healing and pain in women following cesarean delivery.

Conditions

Wound Healing; Caesarean Section

Keywords

Caesarean section; wound healing; pain; St. John's wort oil

Outcome Measures

Primary Outcomes (3)

• pre-test post-test

  In the first follow-up, a dressing will be made with St. John's wort oil and the woman will be told how to make a dressing with this oil. It will be explained to the woman to make a dressing with St. John's wort oil at the incision site once a day every day. The incision site will be photographed for women who give permission.

  6 months

• pre-test post-test

  On the 15th day, which is the second follow-up, the wound site will be evaluated by the researcher. The incision site of the women who give permission will be photographed. She will be told to continue the application of St. John's wort oil.

  6 months

• pre-test post-test

  The third follow-up will be performed on the 25th postpartum day. REEDA Scale and NRS Scale will be applied. REEDA Scale: REEDA scale is used in the evaluation of episiotomy and cesarean incision wounds. The REEDA scale was developed by Davidson in 1970 and used in his master's thesis on the monitoring of wound healing in the perineum. The validity and reliability study of the scale was conducted by Hill in 1990. In Turkey, the validity and reliability study of the REEDA Scale was conducted by Üstünsöz and used in her master's thesis titled "The Effect of Hot and Cold Applications in Episiotomy Healing". The scale has five sub-dimensions: redness, edema, ecchymosis, discharge and approximation of wound edges. Each sub-dimension of the scale is graded using a 4 (four) point Likert-type rating. The evaluation is made between 0-3. The sum of the scale score varies between 0-15. The higher the scale score, the worse the wound healing.

  6 months

Study Arms (2)

Experimental group

EXPERIMENTAL

At the first follow-up, wound dressing will be performed using St. John's Wort oil, and participants will be instructed on how to apply the dressing themselves. They will be advised to apply the oil to the incision site once daily. With the participant's consent, photographs of the incision area will be taken. At the second follow-up, on postpartum day 15, the incision site will be evaluated by the researcher. With consent, photographs of the incision site will again be taken. Participants will be instructed to continue applying the oil daily. The third follow-up will take place on postpartum day 25, during which the REEDA Scale and the Numeric Rating Scale (NRS) will be administered to assess wound healing and pain.

Other: Caesarean section scar dressing with St. John's wort oil

control

NO INTERVENTION

No intervention will be made to the control group. Only measurements will be made on parallel dates with the experimental group.

Interventions

Caesarean section scar dressing with St. John's wort oil OTHER

Dressing the incision site with St. John's wort oil once a day every day

Experimental group

Eligibility Criteria

• Age: 18 Years - 45 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Volunteering to participate in the research,
• Having had a cesarean section,
• Her first cesarean section,
• Being fluent in Turkish.

You may not qualify if:

• Not wanting to participate in the research,
• The existence of a communication barrier.

Sponsors & Collaborators

• Sakarya University: lead

Study Sites (1)

Sakarya Üniversity

Sakarya, 54000, Turkey (Türkiye)

RECRUITING

MeSH Terms

Conditions

Pain

Interventions

Hypericum extract LI 160

Condition Hierarchy (Ancestors)

Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Bilge Nur Yıldırım Bayraktar, PhD

  sakarya üniversity

  STUDY CHAIR

• Kevser İLÇİOĞLU Associate Professor, PhD

  sakarya üniversity

  STUDY DIRECTOR

Central Study Contacts

Bilge Nur Yıldırım Bayraktar Dr., PhD

CONTACT

507-421-25-70; bilgeyildirim41@gmail.com

Güleser ADA Dr, PhD

CONTACT

538-450-85-47; gada@bartin.edu.tr

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Research Assistant Dr.

Study Record Dates

• First Submitted: May 30, 2025
• First Posted: June 10, 2025
• Study Start: June 25, 2025
• Primary Completion: December 30, 2025
• Study Completion: April 30, 2026
• Last Updated: June 10, 2025

Record last verified: 2025-05

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)