Nutritional Indices and Inflammatory Markers in MASLD

NCT07834905 | Not Yet Recruiting

• 1 other identifier: MASLD-Nutritional-Indices-Assi
• Study Type: observational
• Target: 180
• Locations: 0 countries
• Sites: N/A

Brief Summary

Metabolic Dysfunction-Associated steatotic Liver Diseases MASLD affects approximately 25 percent of population. Systemic inflammation plays role in MASLD progression. This cross-sectional observational study at Assiut University Hospitals will include 180 participants aged 18 to 65 years divided into 90 with MASLD and 90 without MASLD over one year. Nutritional indices Prognostic Nutritional Index PNI and Controlling Nutritional Status CONUT score will be calculated from albumin lymphocyte count and cholesterol. CBC-based inflammatory indices SIRI SII PIV PWR PLR MPR WNR NLR will be calculated. MASLD fibrosis score based on age BMI diabetes AST ALT ratio platelet albumin and FibroScan will assess fibrosis F0-F2 versus F3-F4. Aim to evaluate correlation between PNI CONUT and MASLD and role of inflammatory indices as predictors for MASLD and advanced fibrosis.

Conditions

Liver Fibrosis; Malnutrition; Non-Alcoholic Fatty Liver Disease

Keywords

SII SIRI; CONUT; MASLD; PNI; FibroScan; NAFLD fibrosis score

Outcome Measures

Primary Outcomes (1)

• Correlation Between Prognostic Nutritional Index PNI and MASLD Presence

  PNI calculated as 10 x serum albumin g per dL plus 0.005 x total lymphocyte count per mm3 will be compared between MASLD and non-MASLD groups to evaluate association with MASLD presence

  Baseline

Secondary Outcomes (3)

• Predictive Value of CBC-Derived Inflammatory Indices SIRI SII PIV for MASLD

  Baseline

• Predictive Value of PLR NLR MPR PWR for Liver Fibrosis Severity

  Baseline

• MASLD Fibrosis Score and FibroScan for Advanced Fibrosis

  Baseline

Study Arms (2)

MASLD

Participants diagnosed with metabolic dysfunction-associated steatotic liver disease.

Non-MASLD

Participants without metabolic dysfunction-associated steatotic liver disease.

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adults aged 18-65 years attending Assiut University Hospitals, divided into those with MASLD and those without MASLD.

You may qualify if:

• Age 18 to 65 years
• Written informed consent

You may not qualify if:

• Acute infection
• Major surgery or recent trauma within the last 6 months
• Known malignancy
• Previous history of bariatric surgery
• History of liver cirrhosis

Sponsors & Collaborators

• Assiut University: lead

MeSH Terms

Conditions

Liver Cirrhosis; Malnutrition; Non-alcoholic Fatty Liver Disease

Condition Hierarchy (Ancestors)

Liver Diseases; Digestive System Diseases; Fibrosis; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Nutrition Disorders; Nutritional and Metabolic Diseases; Fatty Liver

Study Officials

• Hanan m Ahmed, prof

  Internal Medicine Department, Assiut University Hospitals

  STUDY CHAIR

Central Study Contacts

Yara M Saber, Resident

CONTACT

01005184823; yara.mahmoud401@med.aun.edu.eg

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Resident Physician

Study Record Dates

• First Submitted: September 17, 2026
• First Posted: September 22, 2026
• Study Start: September 20, 2026
• Primary Completion (Estimated): September 20, 2027
• Study Completion (Estimated): March 10, 2028
• Last Updated: September 22, 2026

Record last verified: 2026-09

Data Sharing

• IPD Sharing: Will not share