Is There a Relationship Between Uric Acid Level and Liver Fibrosis in Obese Patients

NCT07168551 | Not Yet Recruiting

• 1 other identifier: UNLF
• Study Type: observational
• Target: 111
• Locations: 0 countries
• Sites: N/A

Brief Summary

1. 1.Identifying the association between hyperuricemia and NAFLD can lead to early detection and prevention of liver fibrosis in adult obese patients.
2. 2.Understanding the relationship between hyperuricemia and NAFLD can inform targeted therapy, such as urate-lowering treatment, to potentially slow disease progression.

Conditions

Hyperuricemia; NAFLD (Nonalcoholic Fatty Liver Disease); Liver Fibrosis

Outcome Measures

Primary Outcomes (1)

• Prevalence of NAFLD

  The proportion of adult obese patients with NAFLD in the study population

  1 year

Secondary Outcomes (1)

• Serum uric acid level

  1 year

Study Arms (3)

1- obese +-nafld+- fibrosis

Obese patients with non alcoholic fatty liver disease with fibrosis

Diagnostic Test: *Lab Methods:* 1- Serum Uric Acid levels 2-Liver Function Tests 3- Lipid Profile . 4- Haemoglobin A1c level . 5- Serum glucose level .; Radiation: *Imaging Studies:* 1- Ultrasound 2 - FibroScan; Device: Instruments:* 1- *Automated Analyzers*: Used for blood tests, such as serum uric acid and liver function tests.

obese +- hyperuricemia +- nfld+- fibrosis

Obese patients with hyperuricemia and non alcoholic liver disease and fibrosis

Diagnostic Test: *Lab Methods:* 1- Serum Uric Acid levels 2-Liver Function Tests 3- Lipid Profile . 4- Haemoglobin A1c level . 5- Serum glucose level .; Radiation: *Imaging Studies:* 1- Ultrasound 2 - FibroScan; Device: Instruments:* 1- *Automated Analyzers*: Used for blood tests, such as serum uric acid and liver function tests.

Healthy controls

Healthy controls

Diagnostic Test: *Lab Methods:* 1- Serum Uric Acid levels 2-Liver Function Tests 3- Lipid Profile . 4- Haemoglobin A1c level . 5- Serum glucose level .; Radiation: *Imaging Studies:* 1- Ultrasound 2 - FibroScan; Device: Instruments:* 1- *Automated Analyzers*: Used for blood tests, such as serum uric acid and liver function tests.

Interventions

*Lab Methods:* 1- Serum Uric Acid levels 2-Liver Function Tests 3- Lipid Profile . 4- Haemoglobin A1c level . 5- Serum glucose level . DIAGNOSTIC_TEST

Lab methods

1- obese +-nafld+- fibrosis; Healthy controls; obese +- hyperuricemia +- nfld+- fibrosis

*Imaging Studies:* 1- Ultrasound 2 - FibroScan RADIATION

Imaging

1- obese +-nafld+- fibrosis; Healthy controls; obese +- hyperuricemia +- nfld+- fibrosis

Instruments:* 1- *Automated Analyzers*: Used for blood tests, such as serum uric acid and liver function tests. DEVICE

Instrument

1- obese +-nafld+- fibrosis; Healthy controls; obese +- hyperuricemia +- nfld+- fibrosis

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult obese patients

You may qualify if:

• Age: Adults (typically 18-65 years old)
• Body Mass Index (BMI): Obese patients with a BMI ≥ 30 kg/m²
• Hyperuricemia : Elevated serum uric acid levels (typically \> 7 mg/dL for men and \> 6 mg/dL for women)

You may not qualify if:

• excessive alcohol consumption ( \> 20 gm /day in men and 10 in g /day in women )
• use of steatogenic within the past 6 months
• positive test for hepatitis B surface antigen and hepatitis B core antibody
• Drug induced liver injury and autoimmune hepatitis
• cirrhosis and other causes of liver disease

Sponsors & Collaborators

• Assiut University: lead

MeSH Terms

Conditions

Hyperuricemia; Non-alcoholic Fatty Liver Disease; Liver Cirrhosis

Interventions

Hematologic Tests; Liver Function Tests

Condition Hierarchy (Ancestors)

Pathologic Processes; Pathological Conditions, Signs and Symptoms; Fatty Liver; Liver Diseases; Digestive System Diseases; Fibrosis

Intervention Hierarchy (Ancestors)

Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Investigative Techniques; Diagnostic Techniques, Digestive System

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Internal medicine Resident doctor

Study Record Dates

• First Submitted: August 27, 2025
• First Posted: September 11, 2025
• Study Start: October 1, 2025
• Primary Completion (Estimated): October 1, 2026
• Study Completion (Estimated): December 1, 2026
• Last Updated: September 15, 2025

Record last verified: 2025-08