Assessment of Nutritional Status in Critically Ill Children in PICU

NCT07830966 | Not Yet Recruiting

• 1 other identifier: PICU-Nutrition-Assiut-26
• Study Type: observational
• Target: 103
• Locations: 0 countries
• Sites: N/A

Brief Summary

This prospective cohort study aims to assess the nutritional status of critically ill children aged 1 month to 5 years admitted to the pediatric intensive care unit using a comprehensive ABCD approach including anthropometric, biochemical, clinical, and dietary assessment within 48 hours of admission, and to evaluate its association with clinical outcomes including duration of mechanical ventilation, length of PICU stay, and mortality.

Conditions

Malnutrition; Critical Illness

Keywords

PICU; ABCD; Pediatric critical care; Mechanical ventilation; Assiut; nutritional assessment

Outcome Measures

Primary Outcomes (1)

• Nutritional status at PICU admission assessed by ABCD approach

  Number of children classified as malnourished based on comprehensive ABCD assessment including anthropometric measurements body mass index z-score mid-upper arm circumference skinfold thickness, biochemical markers albumin prealbumin total protein, clinical signs of muscle and fat loss, and dietary intake, obtained within 48 hours of PICU admission

  At baseline within 48 hours of admission

Secondary Outcomes (4)

• Duration of mechanical ventilation

  Up to 30 days

• Length of PICU stay

  Up to 30 days

• PICU mortality

  Up to 30 days

• Feeding intolerance and refeeding syndrome

  Up to 30 days

Study Arms (1)

Critically ill children in PICU

Children aged 1 month to 5 years admitted to PICU with expected stay greater than 48 hours who will undergo comprehensive nutritional assessment using ABCD approach within 48 hours of admission

Eligibility Criteria

• Age: 1 Month - 5 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17)
• Sampling Method: Non-Probability Sample

Study Population

Critically ill children aged 1 month to 5 years admitted to PICU at Assiut University Children Hospital

You may qualify if:

• Age from 1 month to 5 years
• Admitted to PICU with expected length of stay greater than 48 hours
• Written informed consent from parents or legal guardians

You may not qualify if:

• Chronic renal or hepatic disease known to affect serum protein levels
• Incomplete medical records or discharged or transferred before first laboratory sample could be obtained
• Receiving nutritional support enteral or parenteral prior to PICU admission for condition unrelated to current critical illness

Sponsors & Collaborators

• Assiut University: lead

Related Publications (4)

• Tume LN, Valla FV, Joosten K, Jotterand Chaparro C, Latten L, Marino LV, Macleod I, Moullet C, Pathan N, Rooze S, van Rosmalen J, Verbruggen SCAT. Nutritional support for children during critical illness: European Society of Pediatric and Neonatal Intensive Care (ESPNIC) metabolism, endocrine and nutrition section position statement and clinical recommendations. Intensive Care Med. 2020 Mar;46(3):411-425. doi: 10.1007/s00134-019-05922-5. Epub 2020 Feb 20.

  PMID: 32077997 BACKGROUND

• Hulst JM, Huysentruyt K, Gerasimidis K, Shamir R, Koletzko B, Chourdakis M, Fewtrell M, Joosten KF; Special Interest Group Clinical Malnutrition of ESPGHAN. A Practical Approach to Identifying Pediatric Disease-Associated Undernutrition: A Position Statement from the ESPGHAN Special Interest Group on Clinical Malnutrition. J Pediatr Gastroenterol Nutr. 2022 May 1;74(5):693-705. doi: 10.1097/MPG.0000000000003437. Epub 2022 Mar 3.

  PMID: 35258497 BACKGROUND

• Abera EG, Sime H. The prevalence of malnutrition among critically ill children: a systematic review and meta-analysis. BMC Pediatr. 2023 Nov 21;23(1):583. doi: 10.1186/s12887-023-04419-x.

  PMID: 37986053 BACKGROUND

• Agrawal A, Sharma S, Janjua D, Jadon G, Chanchlani R, Dsouza V. Impact of nutritional status on the mortality and clinical outcomes of children admitted to the pediatric intensive care unit: A systematic review and meta-analysis. Clin Nutr. 2025 Aug;51:28-39. doi: 10.1016/j.clnu.2025.06.002. Epub 2025 Jun 6.

  PMID: 40516325 BACKGROUND

MeSH Terms

Conditions

Malnutrition; Critical Illness

Condition Hierarchy (Ancestors)

Nutrition Disorders; Nutritional and Metabolic Diseases; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Azza A Eltayeb, prof

  pediatrics Department, Assiut University Hospitals

  STUDY CHAIR

Central Study Contacts

Merna A Felly, Resident

CONTACT

+20 15 51377917; mernafelly4@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Resident Physician, Pediatrics

Study Record Dates

• First Submitted: September 15, 2026
• First Posted: September 21, 2026
• Study Start: September 20, 2026
• Primary Completion (Estimated): September 25, 2027
• Study Completion (Estimated): January 10, 2028
• Last Updated: September 22, 2026

Record last verified: 2026-09