NCT07766863

Brief Summary

The purpose of this study is to investigate whether the use of generative artificial intelligence (AI) as a support tool can improve physicians' ability to establish accurate differential diagnoses in emergency care. The main questions it aims to answer are:

  • Is AI-assisted differential diagnosis more accurate than the differential diagnosis performed by physicians?
  • Does physicians' differential diagnosis change - in terms of the number of correct diagnoses - when they have access to AI-assisted differential diagnosis?

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
500

participants targeted

Target at P75+ for all trials

Timeline
32mo left

Started Jun 2026

Typical duration for all trials

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Progress11%
Jun 2026Jun 2029

First Submitted

Initial submission to the registry

May 6, 2026

Completed
1 month until next milestone

Study Start

First participant enrolled

June 8, 2026

Completed
2 months until next milestone

First Posted

Study publicly available on registry

August 17, 2026

Completed
2.8 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 1, 2029

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

June 1, 2029

Last Updated

August 17, 2026

Status Verified

August 1, 2026

Enrollment Period

3 years

First QC Date

May 6, 2026

Last Update Submit

August 11, 2026

Conditions

Keywords

emergency medicineAI (artificial intelligence)Differential diagnosis

Outcome Measures

Primary Outcomes (2)

  • The proportion of cases in which the final diagnosis is ranked highest by the physician and by the AI support, respectively

    Considering the final diagnosis after discharge from the hospital.

    At discharge from the hospital

  • The proportion of physicians' differential diagnosis that change, in terms of the number of correct diagnoses, when they have access to AI-assisted differential diagnosis

    This is meassured after the patient has been discharged from the hospital

    After discharge from the hospital

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

Patients admitted to the hospital via the emergency department at Karolinska University Hospital in Huddinge and Solna, Sweden.

You may qualify if:

  • Adult patients \>18 years admitted through the emergency departments at Karolinska University Hospital in Huddinge and Solna.

You may not qualify if:

  • Children \<18 years
  • Patients without a recorded final diagnosis

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Karolinska University Hospital

Stockholm, Huddinge, 14186, Sweden

RECRUITING

Central Study Contacts

Maria Ygland Rödström, PI

CONTACT

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER GOV
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Specialist in Emergency Medicine, PI, PhD

Study Record Dates

First Submitted

May 6, 2026

First Posted

August 17, 2026

Study Start

June 8, 2026

Primary Completion (Estimated)

June 1, 2029

Study Completion (Estimated)

June 1, 2029

Last Updated

August 17, 2026

Record last verified: 2026-08

Data Sharing

IPD Sharing
Will not share

Individual participant data will not be shared due to privacy considerations, the risk of re-identification, and regulatory requirements governing sensitive health information. Only aggregated and fully anonymized results will be made available.

Locations