Effect of Thymoquinone 0.2% Gel on Bone Density, Bone Width, and Socket Preservation After Tooth Extraction

NCT07765745 | Recruiting

• 1 other identifier: KFSIRB200-852
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to evaluate the clinical and radiographic effects of 0.2% Thymoquinone gel on bone density, bone width, and socket preservation after tooth extraction.

Conditions

Radiographic Evaluation; Bone Density; Bone Width; Socket Preservation; Tooth Extraction; Thymoquinone

Outcome Measures

Primary Outcomes (1)

• Change in alveolar bone density after tooth extraction

  Alveolar bone density will be assessed radiographically using cone-beam computed tomography (CBCT). The change in bone density from baseline to the specified postoperative assessment will be compared.

  3 months after tooth extraction

Secondary Outcomes (2)

• Change in alveolar bone width after tooth extraction

  3 months after tooth extraction

• Change in alveolar ridge dimension after tooth extraction

  3 months after tooth extraction

Study Arms (3)

Group I (Negative Control)

ACTIVE COMPARATOR

Patients will receive gel foam only

Drug: Gel foam

Group II (Study Group 1)

EXPERIMENTAL

Patients will receive 0.2% thymoquinone gel + gel foam.

Drug: Thymoquinone gel + gel foam

Group III (Study Group 2, Nano)

EXPERIMENTAL

Patients will receive nano-formulated 0.2% thymoquinone gel + gel foam.

Drug: Nano-formulated 0.2% thymoquinone gel + gel foam

Interventions

Gel foam DRUG

Patients will receive gel foam only.

Group I (Negative Control)

Thymoquinone gel + gel foam DRUG

Patients will receive 0.2% thymoquinone gel + gel foam.

Group II (Study Group 1)

Nano-formulated 0.2% thymoquinone gel + gel foam DRUG

Patients will receive nano-formulated 0.2% thymoquinone gel + gel foam.

Group III (Study Group 2, Nano)

Eligibility Criteria

• Age: 18 Years - 50 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Age: 18-50 years.
• Both sexes.
• Patients requiring extraction of upper posterior teeth will be recruited.

You may not qualify if:

• Healthy subjects with intact sockets after extraction.
• Normal mouth opening and good oral hygiene.
• No systemic conditions affecting bone healing.

Sponsors & Collaborators

• Kafrelsheikh University: lead

Study Sites (1)

Kafrelsheikh University

Kafr ash Shaykh, Kafrelsheikh, 33516, Egypt

RECRUITING

MeSH Terms

Interventions

Vaginal Creams, Foams, and Jellies

Intervention Hierarchy (Ancestors)

Dosage Forms; Pharmaceutical Preparations; Feminine Hygiene Products; Equipment and Supplies

Central Study Contacts

Muataz A Karimeh, Bachelor

CONTACT

00201027988331; moataz.karema1998@gmail.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Oral and Maxillofacial Surgery, Faculty of Dentistry, Kafrelsheikh University, Kafrelsheikh, Egypt.

Study Record Dates

• First Submitted: August 10, 2026
• First Posted: August 14, 2026
• Study Start: February 1, 2026
• Primary Completion (Estimated): February 1, 2027
• Study Completion (Estimated): February 1, 2027
• Last Updated: August 14, 2026

Record last verified: 2026-08

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL
• Time Frame: After the end of study for one year.
• Access Criteria: The data will be available upon a reasonable request from the corresponding author

Locations

EG (1)