Assessment of Volumetric Changes After Socket Preservation in the Anterior Region Using Sticky Dentin Versus Sticky Bone

NCT07846384 | Completed DMC

• 1 other identifier: 47115
• Study Type: interventional
• Target: 28
• Locations: 1 country
• Sites: 1

Brief Summary

After tooth extraction the alveolar ridge undergoes an unescapable physiological phase of remodeling. The major changes occur during the first three months of healing with a reduction in the dimension of the socket of about 11%-22% vertical bone loss and 29%-63% horizontal bone loss. Such dimensional change will compromise prosthetic replacement in the future, so we make alveolar ridge preservation in order to future complications

Conditions

Socket Preservation and Healing Following Simple, Non-surgical Extraction; Socket Preservation

Outcome Measures

Primary Outcomes (2)

• volumetric bone change after socket preservation, and it will be measured by CBCT.

  CBCT will be taken 3 times: first at the baseline before extraction, second during the follow-up period after 3 months, and third after 6 months.

• Change in Alveolar Bone Volume After Socket Preservation Measured by CBCT

  volumetric bone change after socket preservation, and it will be measured by CBCT. Soft tissue change is measured by a periodontal probe. Soft tissue thickness will be measured using an intraoral scanner. pain by VAS score.

  3 months and 6 months

Study Arms (2)

sticky bone group

ACTIVE COMPARATOR

socket preservation using sticky bone (Xenograft + I-PRF) after tooth extraction to avoid future complications and dimensional change following tooth extraction with a bicompatible material with previous studies on the efficacy of the material in alveolar ridge preservation.

Combination Product: sticky dentin group; Combination Product: sticky bone

sticky dentin group

EXPERIMENTAL

socket preservation using sticky dentin (demineralized dentin + I-PRF)

Combination Product: sticky dentin group; Combination Product: sticky bone

Interventions

sticky dentin group COMBINATION_PRODUCT

The autogenous demineralized dentin is used in socket preservation. as it shares a similar composition to the bone. Demineralized dentin is an osteoinductive and osteoconductive material, making it an alternative to xenograft in socket preservation. The addition of the PRF helps in healing and pain reduction. Xenograft is an osteoconductive material, and a previous study showed a reduction in dimensional change following tooth extraction. The effect of the sticky dentin on the bone and soft tissue is measured using the CBCT, intraoral scanner, and periodontal probe.

Also known as: sticky tooth

sticky bone group; sticky dentin group

sticky bone COMBINATION_PRODUCT

Socket preservation using sticky dentin (Xenograft + I-PRF) after tooth extraction.

sticky bone group; sticky dentin group

Eligibility Criteria

• Age: 20 Years - 55 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• patient (20-55) years old
• non-smoker
• medically free
• non-restorable tooth.
• anterior zone
• Type 1 extraction socket

You may not qualify if:

• medically compromised patient (uncontrolled diabetes, hyperthyroidism).
• pregnant female.
• history of chemo or radiotherapy

Sponsors & Collaborators

• October University for Modern Sciences and Arts: lead

Study Sites (1)

Faculty of Dentistry, October University for Modern Sciences and Arts (MSA University)

Giza, 02, Egypt

Location

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: General Dentist, MSc Candidate in Periodontology

Model Details: Research focuses on autogenous demineralized dentin bone in order to overcome problems with the autograft or allograft or synthetic bone. Bone and teeth are very similar in their composition, as both are composed of inorganic substances such as hydroxyapatite and calcium phosphate and organic substances like collagen, as dentin is composed of 65% inorganic and 35% organic substances such as collagen type 1 , growth factors such as bone morphogenic protein, as the perivascular mesenchymal stem cells will differentiate into cartilage and bone through bone morphogenic protein (BMP), so the BMP is responsible for osteoinductivity

Study Record Dates

• First Submitted: September 23, 2026
• First Posted: September 29, 2026
• Study Start: April 25, 2025
• Primary Completion: August 1, 2026
• Study Completion: August 1, 2026
• Last Updated: September 29, 2026

Record last verified: 2024-11

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)