Demineralized Dentin Matrix Versus Mineralized Plasmatic Matrix on Alveolar Ridge Preservation in Molar Extraction Sites

NCT07239193 | Not Yet Recruiting

• 1 other identifier: DDM in socket preservation
• Study Type: interventional
• Target: 24
• Locations: 1 country
• Sites: 1

Brief Summary

When a tooth is removed, the bone around it (called the alveolar ridge) naturally shrinks. This study compares two bone grafting materials to find out which one better preserves bone after molar extraction: Demineralized Dentin Matrix (DDM): A material made from the patient's own extracted tooth, treated to remove minerals while keeping bone-forming proteins. Mineralized Plasmatic Matrix (MPM): A mixture of a standard bone substitute and platelet-rich plasma from the patient's blood.

Conditions

Socket Preservation; Alveolar Ridge Preservation

Keywords

socket preservation; alveolar ridge preservation; DDM; demineralized dentin matrix; MPM; mineralized plasmatic matrix

Outcome Measures

Primary Outcomes (1)

• Change in Alveolar Ridge Width

  Measurement of horizontal bone width at the extraction site using cone-beam computed tomography (CBCT).

  Baseline (immediately postoperative) and 4 months postoperatively.

Secondary Outcomes (3)

• Change in Alveolar Ridge Height

  Baseline (immediately postoperative) and 4 months postoperatively.

• Change in Bone Density

  Baseline (immediately postoperative) and 4 months postoperatively.

• Postoperative Pain

  2 days, 1 week, and 1 month postoperatively.

Study Arms (2)

Demineralized Dentin Matrix (DDM) + Platelet-Rich Fibrin (PRF)

EXPERIMENTAL

Participants in this group will receive socket grafting using Demineralized Dentin Matrix (DDM) prepared from their own extracted tooth. The dentin is cleaned, ground into particles, demineralized using 0.6 N hydrochloric acid, rinsed with saline, and mixed with autologous Platelet-Rich Fibrin (PRF) before being placed into the extraction socket. The socket is then closed with resorbable sutures for healing.

Biological: Demineralized Dentin Matrix (DDM) + Platelet-Rich Fibrin (PRF)

Mineralized Plasmatic Matrix (MPM)

ACTIVE COMPARATOR

Participants in this group will receive socket grafting using a Mineralized Plasmatic Matrix (MPM) composed of a commercially available xenograft mixed with Platelet-Rich Plasma (PRP). The mixture forms a cohesive mineralized matrix that is placed into the extraction socket and stabilized with sutures.

Biological: Mineralized Plasmatic Matrix (MPM)

Interventions

Demineralized Dentin Matrix (DDM) + Platelet-Rich Fibrin (PRF) BIOLOGICAL

Autogenous dentin-derived grafting material is used as a bone substitute for alveolar ridge preservation following molar extraction. PRF, obtained from the patient's centrifuged blood, is mixed with DDM to enhance graft stability and promote healing.

Demineralized Dentin Matrix (DDM) + Platelet-Rich Fibrin (PRF)

Mineralized Plasmatic Matrix (MPM) BIOLOGICAL

A xenogenic bone substitute is mixed with autologous platelet-rich plasma to form a mineralized plasmatic matrix, which serves as a control graft for ridge preservation after molar extraction.

Mineralized Plasmatic Matrix (MPM)

Eligibility Criteria

• Age: 18 Years - 55 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• \- Non-restorable tooth indicated for extraction Multi-rooted teeth Age group of 18 to 55 years Patients free from any systemic disease that may affect bone healing.

You may not qualify if:

• \- Pregnant females Active infection at extraction site Smokers Systemic conditions affecting healing (e.g. diabetes, medications as bisphosphonates...) Poor oral hygiene. Patient with systemic disease that may affect bone healing. o Uncooperative patient.

Sponsors & Collaborators

• Cairo University: lead

Study Sites (1)

Faculty of Dentistry, Cairo University - Department of Oral and Maxillofacial Surgery

Cairo, 12613, Egypt

Location

MeSH Terms

Interventions

Demineralized Dentin Matrix; DDMS

Study Officials

• Tarek Ibrahim ElGhareeb, Phd

  Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Cairo University

  STUDY CHAIR

• Salah Eldin ElAbbasy, Phd

  Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Cairo University

  STUDY DIRECTOR

• Ahmed Suliman Ahmed, Bds

  Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Cairo University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Masking Details: Single-blind design - participants will not be informed which grafting material (DDM or MPM) was used in their treatment. The operating surgeons and data analysts will be aware of the allocation due to the nature of the procedures.
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Dr

Model Details: Participants will be randomly assigned to one of two parallel groups in a 1:1 ratio. Group A will receive socket grafting with autogenous Demineralized Dentin Matrix (DDM) mixed with Platelet-Rich Fibrin (PRF), while Group B will receive Mineralized Plasmatic Matrix (MPM) composed of xenograft mixed with Platelet-Rich Plasma (PRP). Each participant will receive only one type of intervention.

Study Record Dates

• First Submitted: November 16, 2025
• First Posted: November 20, 2025
• Study Start: December 1, 2025
• Primary Completion (Estimated): July 1, 2026
• Study Completion (Estimated): November 1, 2026
• Last Updated: November 20, 2025

Record last verified: 2025-11

Locations

EG (1)