NCT07344025

Brief Summary

Socket preservation procedures after tooth extraction have been designed and implemented to maintain the volume of the bone and gingival tissues, which can decrease following the extraction of the teeth. In this clinical trial we will compare clinically and histologically the effectiveness of two distinct bovine bone graft materials; an allograft and a xenograft, in alveolar ridge preservation procedures following tooth extraction .

Trial Health

57
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
18

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Jan 2026

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 1, 2026

Completed
Same day until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 1, 2026

Completed
6 days until next milestone

First Submitted

Initial submission to the registry

January 7, 2026

Completed
8 days until next milestone

First Posted

Study publicly available on registry

January 15, 2026

Completed
3 months until next milestone

Study Completion

Last participant's last visit for all outcomes

April 1, 2026

Completed
Last Updated

January 20, 2026

Status Verified

January 1, 2026

Enrollment Period

Same day

First QC Date

January 7, 2026

Last Update Submit

January 15, 2026

Conditions

Socket PreservationAlveolar Ridge AugmentationDental Implants

Keywords

Alveolar ridge preservationAllograftBovine xenograft

Outcome Measures

Primary Outcomes (1)

  • Change in buccolingual ridge width

    Difference in ridge width measured clinically and radiographically between baseline and 2-3 months post-extraction

    Baseline to 2-3 months

Secondary Outcomes (1)

  • Histomorphometric outcomes

    2-3 months

Study Arms (2)

Allograft Group

EXPERIMENTAL

Extraction sockets grafted with cortico-cancellous particulate allograft and covered with a collagen membrane.

Procedure: Socket Preservation with Graft Material Allograft

Xenograft Group

EXPERIMENTAL

Extraction sockets grafted with xenograft material and covered with a collagen membrane.

Procedure: Socket Preservation with Graft Material Allograft

Interventions

Socket Preservation with Graft Material AllograftPROCEDURE

Socket preservation will be performed after tooth extraction using graft material Allograft or Xenograft according to standard surgical protocol.

Also known as: Socket Preservation with Graft Material Xenograft
Allograft GroupXenograft Group

Eligibility Criteria

Age21 Years - 50 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • Systemically healthy individuals
  • Non-smokers
  • Age between 21 and 50 years
  • Indicated for tooth extraction and socket preservation
  • Good oral hygiene (full-mouth plaque score \<20%)
  • Willingness to participate and provide informed consent

You may not qualify if:

  • Stage III or IV periodontitis
  • Active periodontal or periapical infection
  • Severely resorbed sockets (buccal bone height \<5 mm)
  • Smoking more than 10 cigarettes per day
  • Pregnancy
  • Systemic conditions or medications affecting bone metabolism

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

College of Dentistry, Pharos University

Alexandria, Egypt

RECRUITING

Study Officials

  • H Sakr, PhD

    Pharos university

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Haitham Sakr, PhD

CONTACT

3877700haitham.sakr@pua.edu.eg

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
TRIPLE
Who Masked
PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Principle investigator

Study Record Dates

First Submitted

January 7, 2026

First Posted

January 15, 2026

Study Start

January 1, 2026

Primary Completion

January 1, 2026

Study Completion

April 1, 2026

Last Updated

January 20, 2026

Record last verified: 2026-01

Locations

EG(1)