Comparative Efficacy of Therapeutic Ultrasound and Neurodynamic Techniques for Carpal Tunnel Syndrome

NCT07743879 | Completed

• 1 other identifier: RU/03/FMHS/2025
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

This randomized controlled trial compares the efficacy of therapeutic ultrasound alone, neurodynamic techniques alone, and combined therapeutic ultrasound and neurodynamic techniques in patients with mild to moderate carpal tunnel syndrome.

Conditions

Carpal Tunnel Syndrome (CTS)

Keywords

therapeutic ultrasound; neurodynamic techniques; nerve conduction study; conservative management

Outcome Measures

Primary Outcomes (3)

• Pain Intensity

  Measure Description: Measured using the unabbreviated Visual Analog Scale (VAS). This scale ranges from 0 to 10 cm, where 0 represents no pain and 10 represents the worst imaginable pain. Higher scores indicate a worse outcome (greater pain intensity).

  Baseline and 6 weeks post-intervention

• Symptom Severity

  Measure Description: Assessed using the unabbreviated Boston Carpal Tunnel Questionnaire Symptom Severity Scale (BCTQ-SSS). The scale ranges from 1 to 5, with higher scores indicating a worse outcome (more severe symptoms).

  Baseline and 6 weeks post-intervention

• Functional Status

  Measure Description: Assessed using Boston Carpal Tunnel Questionnaire Functional Status Scale (BCTQ-FSS). The scale ranges from 1 to 5, with higher scores indicating a worse outcome (greater functional disability/impairment).

  Baseline and 6 weeks post-intervention

Study Arms (3)

Therapeutic Ultrasound Group

EXPERIMENTAL

Continuous therapeutic ultrasound applied to the volar wrist at 1.5 W/cm² for 8 to 10 minutes per session, 3 times per week for 6 weeks.

Other: Neurodynamic Techniques

Neurodynamic Techniques Group

EXPERIMENTAL

Median nerve neurodynamic mobilization (progressing from sliders to tensioners), 3 sets of 10 repetitions, 3 times per week for 6 weeks.

Other: Neurodynamic Techniques

Combined Therapy Group

EXPERIMENTAL

Combined application of therapeutic ultrasound followed by neurodynamic techniques in the same session, 3 times per week for 6 weeks.

Other: Neurodynamic Techniques

Interventions

Neurodynamic Techniques OTHER

Median nerve neurodynamic mobilization (progressing from sliders to tensioners), 3 sets of 10 repetitions.

Combined Therapy Group; Neurodynamic Techniques Group; Therapeutic Ultrasound Group

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Clinical diagnosis of mild to moderate carpal tunnel syndrome confirmed by electrophysiological testing.
• Age between 18 and 65 years.
• Presence of symptoms (pain, numbness, tingling) for at least 3 months.

You may not qualify if:

• History of previous carpal tunnel release surgery or wrist trauma.
• Corticosteroid injection into the wrist within the past 3 months.
• Cervical radiculopathy, polyneuropathy, or other upper extremity neurological disorders.
• Pregnancy or lactation.
• Contraindications to therapeutic ultrasound (e.g., active infection, metallic implants in the treatment area, malignant tumors).

Sponsors & Collaborators

• IBB University: lead
• Al-Razi University: collaborator

Study Sites (1)

Ibb University

Ibb, nine, Yemen

Location

MeSH Terms

Conditions

Carpal Tunnel Syndrome

Condition Hierarchy (Ancestors)

Median Neuropathy; Mononeuropathies; Peripheral Nervous System Diseases; Neuromuscular Diseases; Nervous System Diseases; Nerve Compression Syndromes; Cumulative Trauma Disorders; Sprains and Strains; Wounds and Injuries

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor and Head of the Department of Human Medicine

Study Record Dates

• First Submitted: July 29, 2026
• First Posted: August 4, 2026
• Study Start: February 25, 2025
• Primary Completion: November 1, 2025
• Study Completion: November 26, 2025
• Last Updated: August 4, 2026

Record last verified: 2026-07

Data Sharing

• IPD Sharing: Will not share

Locations

YE (1)