NCT07698704

Brief Summary

This study will be conducted to compare the effect of popliteus muscle release and patellofemoral mobilization on pain intensity, function, and quadriceps muscle strength in patients with patellofemoral pain syndrome?

Trial Health

65
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
48

participants targeted

Target at P25-P50 for not_applicable

Timeline
3mo left

Started Jul 2026

Shorter than P25 for not_applicable

Status
not yet recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Progress16%
Jul 2026Nov 2026

First Submitted

Initial submission to the registry

July 7, 2026

Completed
6 days until next milestone

First Posted

Study publicly available on registry

July 13, 2026

Completed
2 days until next milestone

Study Start

First participant enrolled

July 15, 2026

Completed
4 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

November 1, 2026

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

November 1, 2026

Last Updated

July 13, 2026

Status Verified

July 1, 2026

Enrollment Period

4 months

First QC Date

July 7, 2026

Last Update Submit

July 7, 2026

Conditions

Keywords

Popliteus Muscle ReleasePatellofemoral MobilizationPatellofemoral Pain Syndrome

Outcome Measures

Primary Outcomes (1)

  • pain intensity

    The scale used will be the visual analogue scale (VAS), which consists of a line, usually 10 cm long, the patient will be instructed to place a vertical mark on to indicate his/ her pain, ranging from no pain or discomfort (0), to the worst pain that could possibly feel

    up to four weeks

Secondary Outcomes (2)

  • knee disability

    up to four weeks

  • quadriceps muscle strength

    up to four weeks

Study Arms (3)

Popliteus Muscle Release

EXPERIMENTAL

Sixteen patients with patellofemoral pain syndrome will receive popliteus muscle release. plus traditional physical therapy three times a week for 4 weeks.

Other: Popliteus Muscle ReleaseOther: traditional therapy

Patellofemoral Mobilization

EXPERIMENTAL

Sixteen patients with patellofemoral pain syndrome will receive patellofemoral mobilization plus traditional physical therapy three times a week for 4 weeks.

Other: Patellofemoral MobilizationOther: traditional therapy

traditional therapy

ACTIVE COMPARATOR

Sixteen patients with patellofemoral pain syndrome will receive traditional physical therapy three times a week for 4 weeks.

Other: traditional therapy

Interventions

the participant will lie supine and relaxed on a treatment bench. The therapist will begin the treatment by flexing the participant's knee to approximately 15-25 degrees. Then, the therapist will apply pressure to the popliteus muscle while simultaneously extending the knee to approximately 5 degrees of flexion. When the knee is extended, the pressure will be released. The therapist will repeat this procedure for up to 2 minutes plus tradional therapy

Popliteus Muscle Release

Following the clinical guidelines established by Brukner and Khan, the mobilization will be performed with the patient in a supine position to ensure complete relaxation of the quadriceps musculature, thereby minimizing joint compressive forces. The intervention will include multidirectional glides tailored to specific functional deficits:Superior glides,Inferior glides,Medial-lateral excursions and tilt mobilization.Each mobilization will be applied as a gentle sustained glide for duration of 30 to 60 seconds per repetition

Patellofemoral Mobilization

patients will receive quadriceps muscle strength, hip extension strength, hamstring stretch.

Patellofemoral MobilizationPopliteus Muscle Releasetraditional therapy

Eligibility Criteria

Age18 Years - 30 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64)

You may qualify if:

  • Male and female participants aged 18-30 years.
  • minimum history of 3 months of unilateral PFP.
  • pain intensity score of ≥3 on a 10-cm Visual Analog Scale (VAS) for worst pain experienced during the previous week.
  • Pain reproduced during at least two of the following functional activities: stair ascent or descent, running, hopping, prolonged sitting, squatting, or kneeling.
  • Presence of pain on at least one of the following clinical tests: patellar compression test or palpation of the patellar facets.

You may not qualify if:

  • Clinical, x-ray, or MRI findings indicative of other specific pathology including osteoarthritis, meniscal, ligament or cartilage injury, apophysitis.
  • Recurrent patellar subluxation or dislocation.
  • Cortisone use over an extended period of time.
  • Previous surgery to the knee joint; trauma to the knee joint affecting the presenting clinical condition.
  • Lower limb deformities.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

MeSH Terms

Conditions

Patellofemoral Pain Syndrome

Condition Hierarchy (Ancestors)

Joint DiseasesMusculoskeletal Diseases

Central Study Contacts

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Masking Details
opaque sealed envelope
Purpose
TREATMENT
Intervention Model
PARALLEL
Model Details: Popliteus Muscle Release and Patellofemoral Mobilization
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
principle investigator : mohamed abdelalim bahig

Study Record Dates

First Submitted

July 7, 2026

First Posted

July 13, 2026

Study Start

July 15, 2026

Primary Completion (Estimated)

November 1, 2026

Study Completion (Estimated)

November 1, 2026

Last Updated

July 13, 2026

Record last verified: 2026-07