NCT07664566

Brief Summary

This study will be conducted to investigate the effect of core stability exercises versus proprioceptive training in patients with patellofemoral pain syndrome.

Trial Health

65
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
63

participants targeted

Target at P50-P75 for not_applicable

Timeline
8mo left

Started Jun 2026

Shorter than P25 for not_applicable

Status
not yet recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Progress12%
Jun 2026Mar 2027

First Submitted

Initial submission to the registry

June 18, 2026

Completed
6 days until next milestone

First Posted

Study publicly available on registry

June 24, 2026

Completed
6 days until next milestone

Study Start

First participant enrolled

June 30, 2026

Completed
9 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

March 20, 2027

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

March 20, 2027

Last Updated

June 24, 2026

Status Verified

June 1, 2026

Enrollment Period

9 months

First QC Date

June 18, 2026

Last Update Submit

June 18, 2026

Conditions

Keywords

Core Stability ExercisesProprioceptive TrainingPatellofemoral Pain SyndromePain and Function

Outcome Measures

Primary Outcomes (2)

  • pain intensity

    pain will be assessed by VAS which line on a 100 mm , where 0 indicates no pain and 100 indicates the worst possible pain.

    up to four weeks

  • knee disability

    knee disability will be assessed by Kujala Patellofemoral Questionnaire.Which is a 13-item questionnaire including different items on pain related to functioning and activities. The categories within each item are weighted and item scores summed to provide an overall index scored from 0 to 100, where the maximum score of 100 represents no disability.

    up to four weeks

Secondary Outcomes (4)

  • pressure pain threshold

    up to four weeks

  • knee range of motion

    up to four weeks

  • knee proprioception (joint position error)

    up to four weeks

  • quadriceps muscle strength

    up to four weeks

Study Arms (3)

Core Stability Exercises

EXPERIMENTAL

twenty one patients with patellofemoral pain syndrome will receive Core stability exercises + traditional physical therapy three times a week for four weeks.

Other: Core Stability ExercisesOther: traditional therapy

Proprioceptive Training

EXPERIMENTAL

Twenty-one patients with patellofemoral pain syndrome will receive proprioceptive exercises + traditional physical therapy three times a week for four weeks.

Other: Proprioceptive TrainingOther: traditional therapy

traditional therapy

ACTIVE COMPARATOR

twenty one patients with patellofemoral pain syndrome will receive traditional physical therapy three times a week for four weeks.

Other: traditional therapy

Interventions

core stability exercises including warm-up, main training, and cool-down phases; warm up exercises in the form of Cat-Camel exercise will be performed for 5-8 cycles to mobilize the spine and promote smooth segmental motion. The primary main training consisted of McGill's "Big Three" core stabilization exercises, which emphasize endurance and control of the deep stabilizing muscles, curl up, side bridge, and Quadrupedal stance, finallly the cool down phase had dynamic stretching at the end of each session to reduce muscle tension and promote recovery plus tradional therapy

Core Stability Exercises

proprioceptive training consisted of group of exercises for balance on 1 leg on a stable surface and a unstable surface. in addition to tradional therapy.

Proprioceptive Training

tradional therapy in the form of interferential therapy, knee strengthening exercises, knee strengthening exercises, stretching exercises, patellar mobilization and ischemic compression

Core Stability ExercisesProprioceptive Trainingtraditional therapy

Eligibility Criteria

Age18 Years - 40 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64)

You may qualify if:

  • A confirmed diagnosis of Patellofemoral Pain Syndrome (PFPS) based on clinical and radiographic examination, with no evidence of other knee pathologies, as verified by an orthopaedic physician
  • Presence of unilateral PFPS for a minimum duration of three months, indicating a chronic condition
  • Age between 18 and 40 years, representing the typical symptomatic population affected by PFPS
  • Report of increased anterior knee pain during at least two of the following patellofemoral stress-provoking activities: stair ascent or descent, squatting, kneeling, running, or prolonged sitting
  • A positive patellar grind test (Clarke's sign) confirming involvement of the patellofemoral joint

You may not qualify if:

  • Presence of chronic pain conditions unrelated to Patellofemoral Pain Syndrome (PFPS) as Rheumatoid arthritis, Chronic neuropathic pain, chronic low back pain and knee and hip osteoarthritis.
  • Pregnancy or history of recent trauma affecting the pelvic or knee region
  • History of corticosteroid injection in the affected knee
  • Presence of ankle arthritis or gouty arthritis, which may alter lower-limb biomechanics
  • History of previous surgical intervention involving the lumbar spine, hip, knee, or foot
  • Presence of lower-limb structural deformities, including pes planus, knee valgus, or knee varus deformities

Contact the study team to confirm eligibility.

Sponsors & Collaborators

MeSH Terms

Conditions

Patellofemoral Pain SyndromePain

Condition Hierarchy (Ancestors)

Joint DiseasesMusculoskeletal DiseasesNeurologic ManifestationsSigns and SymptomsPathological Conditions, Signs and Symptoms

Central Study Contacts

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Masking Details
opaque sealed envelope
Purpose
TREATMENT
Intervention Model
PARALLEL
Model Details: Core Stability Exercises and Proprioceptive Training
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
principle investigator : Mohamed hassan ibrahim salama

Study Record Dates

First Submitted

June 18, 2026

First Posted

June 24, 2026

Study Start

June 30, 2026

Primary Completion (Estimated)

March 20, 2027

Study Completion (Estimated)

March 20, 2027

Last Updated

June 24, 2026

Record last verified: 2026-06