NCT07633782

Brief Summary

Evaluate the effect of High-Intensity Focused Electromagnetic Therapy on pain, quadriceps strength, and quality of life in patients with patellofemoral pain syndrome

Trial Health

65
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
60

participants targeted

Target at P25-P50 for not_applicable

Timeline
4mo left

Started Jun 2026

Shorter than P25 for not_applicable

Status
not yet recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Progress3%
Jun 2026Oct 2026

First Submitted

Initial submission to the registry

June 2, 2026

Completed
6 days until next milestone

First Posted

Study publicly available on registry

June 8, 2026

Completed
4 days until next milestone

Study Start

First participant enrolled

June 12, 2026

Completed
4 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

October 1, 2026

Expected
7 days until next milestone

Study Completion

Last participant's last visit for all outcomes

October 8, 2026

Last Updated

June 8, 2026

Status Verified

June 1, 2026

Enrollment Period

4 months

First QC Date

June 2, 2026

Last Update Submit

June 2, 2026

Conditions

Outcome Measures

Primary Outcomes (1)

  • Pain level

    Visual Analog Scale will be used to assess pain

    Baseline and after 8 weeks

Secondary Outcomes (2)

  • Quadriceps muscle strength

    Baseline and after 8 weeks

  • Health-related quality of life

    Baseline and after 8 weeks

Study Arms (2)

Study group

ACTIVE COMPARATOR
Device: True High-Intensity Focused Electromagnetic TherapyOther: Traditional Physiotherapy

Control group

SHAM COMPARATOR
Device: Sham High-Intensity Focused Electromagnetic TherapyOther: Traditional Physiotherapy

Interventions

20-30 minute sessions, 2-3 times per week for 8 weeks at a clinically effective, tolerable intensity level designed to elicit supramaximal contractions for the quadriceps muscle.

Study group

The device protocol, application time, and acoustic feedback will the same as the experimental arm, but with the device in the off state and no muscular contractions in the quadriceps muscle .

Control group

Standard rehabilitation program including patellar mobilization with quadriceps and hip abductor strengthening.

Control groupStudy group

Eligibility Criteria

Age18 Years - 45 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64)

You may qualify if:

  • Clinical diagnosis of patellofemoral pain syndrome (anterior or peripatellar knee pain aggravated by at least two activities such as stair climbing, prolonged sitting, squatting, or running).
  • Symptoms persisting for at least 3 months.

You may not qualify if:

  • History of previous knee surgery or trauma (e.g., ligamentous laxity, meniscal tear, or patellar fracture).
  • Concomitant knee pathology (e.g., tibiofemoral osteoarthritis, patellar tendinopathy, or plica syndrome).
  • Presence of metallic implants, pacemakers, or electrical medical devices in the body .
  • Recent corticosteroid or hyaluronic acid injection into the affected knee within the last 3 months.
  • Pregnancy.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

MeSH Terms

Conditions

Patellofemoral Pain Syndrome

Condition Hierarchy (Ancestors)

Joint DiseasesMusculoskeletal Diseases

Central Study Contacts

Saher Lotfy Elgayar, Ph.D

CONTACT

Mohammed Youssef Elhamrawy, Ph.D

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
PARTICIPANT, OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Assistant Professor of Physiotherapy

Study Record Dates

First Submitted

June 2, 2026

First Posted

June 8, 2026

Study Start

June 12, 2026

Primary Completion (Estimated)

October 1, 2026

Study Completion (Estimated)

October 8, 2026

Last Updated

June 8, 2026

Record last verified: 2026-06

Data Sharing

IPD Sharing
Will not share