NCT07697963

Brief Summary

Patients with moderate periodontal destruction underwent mechanical debridement of the pathological changes from the periodontal pockets in one of the randomly selected quadrants and in another, also randomly selected, quadrant. In addition to non-surgical debridement, photodynamic therapy was applied. This comparison between two treatment options was evaluated between subjects who smoke and non-smokers.

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
120

participants targeted

Target at P75+ for early_phase_1

Timeline
Completed

Started Jan 2015

Shorter than P25 for early_phase_1

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 5, 2015

Completed
9 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

October 15, 2015

Completed
2 months until next milestone

Study Completion

Last participant's last visit for all outcomes

December 15, 2015

Completed
10.6 years until next milestone

First Submitted

Initial submission to the registry

July 6, 2026

Completed
7 days until next milestone

First Posted

Study publicly available on registry

July 13, 2026

Completed
Last Updated

July 13, 2026

Status Verified

October 1, 2015

Enrollment Period

9 months

First QC Date

July 6, 2026

Last Update Submit

July 6, 2026

Conditions

Periodontal Disease

Keywords

photodynamic therapy

Outcome Measures

Primary Outcomes (1)

  • Periodontal pocket depth reduction

    6 weeks

Study Arms (2)

Scaling and root planning

ACTIVE COMPARATOR

Non-surgical treatment

Procedure: Scaling and root planing plus placebo

Photodynamic therapy

EXPERIMENTAL

Application of photodynamic therapy as an adjunct to non-surgical therapy

Combination Product: Photodynamic therapy (PDT)

Interventions

Scaling and root planing plus placeboPROCEDURE

Non-surgical treatment of periodontal pockets

Also known as: scaling and root planning
Scaling and root planning
Photodynamic therapy (PDT)COMBINATION_PRODUCT

Photodynamic therapy was applied to a previously treated pocket with non-surgical therapy

Photodynamic therapy

Eligibility Criteria

Age18 Years - 65 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • at least two teeth with periodontal pockets up to 4 mm

You may not qualify if:

  • less than two teeth with periodontal pockets

Contact the study team to confirm eligibility.

Sponsors & Collaborators

MeSH Terms

Conditions

Periodontal Diseases

Interventions

Tooth ExfoliationRoot PlaningPhotochemotherapy

Condition Hierarchy (Ancestors)

Mouth DiseasesStomatognathic Diseases

Intervention Hierarchy (Ancestors)

Dental Physiological PhenomenaDigestive System and Oral Physiological PhenomenaDental ScalingDental ProphylaxisPeriodonticsDentistrySubgingival CurettagePreventive DentistryCombined Modality TherapyTherapeuticsDrug TherapyPhototherapy

Study Design

Study Type
interventional
Phase
early phase 1
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
PARTICIPANT, INVESTIGATOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Dr

Study Record Dates

First Submitted

July 6, 2026

First Posted

July 13, 2026

Study Start

January 5, 2015

Primary Completion

October 15, 2015

Study Completion

December 15, 2015

Last Updated

July 13, 2026

Record last verified: 2015-10

Data Sharing

IPD Sharing
Will not share