Periostin and Non-Surgical Periodontal Treatment

NCT04332965 | Completed

• 1 other identifier: 2017/43
• Study Type: interventional
• Target: 90
• Locations: 0 countries
• Sites: N/A

Brief Summary

A total of 90 subjects, 30 patients with chronic periodontitis, 30 with gingivitis and 30 periodontally healthy subjects were included. Patients with periodontal disease received non-surgical periodontal treatment. Gingival crevicular fluid periostin levels were assessed at baseline, at the 6th week and the 3rd month after treatment.

Conditions

Periodontal Diseases

Keywords

Chronic periodontitis; Gingival crevicular fluid; Gingivitis; Non-surgical periodontal treatment; Periostin

Outcome Measures

Primary Outcomes (1)

• Change in periostin

  Total amount of Periostin (pg/30 sec) in gingival crevicular fluid

  Baseline, 6th week and 3rd month

Secondary Outcomes (1)

• Change in periodontal clinical parameter

  Baseline, 6th week and 3rd month

Study Arms (3)

Patients with chronic periodontitis

EXPERIMENTAL

Patients with CP (n=30) had teeth with 30% periodontal bone loss and ≥ 2 non-adjacent sites per quadrant with probing depth (PD) ≥ 5 mm and bleeding on probing.

Procedure: Non-Surgical Periodontal Treatment

Patients with gingivitis

EXPERIMENTAL

Participants with G (n=30) had gingival index ≥ 2 and other inflammation signs.

Procedure: Non-Surgical Periodontal Treatment

Participants with periodontal healthy

NO INTERVENTION

The H group (n=30) consisted of individuals with no attachment loss, no history of periodontal disease, PD ≤3 mm, and whole-mouth bleeding scores \<10%.

Interventions

Non-Surgical Periodontal Treatment PROCEDURE

Scaling and root planing and polishing with specific curettes were performed to patients and oral hygiene education was provided to each patient.

Also known as: Initial periodontal therapy

Patients with chronic periodontitis; Patients with gingivitis

Eligibility Criteria

• Age: 20 Years - 60 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Clinical diagnosis of chronic periodontitis
• Clinical diagnosis of gingivitis
• Clinical diagnosis of periodontal health

You may not qualify if:

• have any systemic disease
• to be alcohol consumer
• to receive any periodontal therapy in the past 6 months
• to take any drugs regularly
• to be pregnant and/or lactate

Sponsors & Collaborators

• Kırıkkale University: lead

MeSH Terms

Conditions

Periodontal Diseases; Chronic Periodontitis; Gingivitis

Condition Hierarchy (Ancestors)

Mouth Diseases; Stomatognathic Diseases; Periodontitis; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Infections; Gingival Diseases

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: April 1, 2020
• First Posted: April 3, 2020
• Study Start: January 1, 2017
• Primary Completion: January 1, 2018
• Study Completion: April 1, 2018
• Last Updated: April 3, 2020

Record last verified: 2020-04