P-POSSUM for Outcomes After Abdominal Surgery

NCT07667764 | Active Not Recruiting

• 1 other identifier: BM_2026_161
• Study Type: observational
• Target: 3,000
• Locations: 1 country
• Sites: 1

Brief Summary

Postoperative complications after abdominal surgery can lead to prolonged recovery, intensive care admission, and death. The P-POSSUM score is a commonly used surgical risk prediction tool, but its performance may vary between hospitals and patient populations. Frailty, especially in older patients, may also affect postoperative outcomes and may improve risk prediction when added to existing scoring systems. This ambispective observational cohort study evaluates the prognostic value of the P-POSSUM score, with additional assessment of frailty and routine perioperative clinical data, for predicting postoperative complications and treatment outcomes in adult patients undergoing abdominal surgery at Bach Mai Hospital. The study includes retrospective data from January 2025 and prospective data collection through May 2026. No intervention is assigned by the investigators. All patients receive routine perioperative care according to clinical practice. The study will assess the predictive performance of P-POSSUM for postoperative complications and mortality, and will explore whether adding frailty-related variables improves risk prediction.

Conditions

Abdominal Surgery; Postoperative Complications; Surgical Risk Prediction; Postoperative Mortality; Frailty

Keywords

P-POSSUM; Modified Frailty Index; Abdominal surgery; Clinical Frailty Scale; Prognostic score; Perioperative risk assessment

Outcome Measures

Primary Outcomes (1)

• Proportion of patients with postoperative complications within 30 days after abdominal surgery

  The proportion of patients who develop one or more postoperative complications after abdominal surgery. Postoperative complications include surgical, infectious, respiratory, cardiovascular, renal, neurological, bleeding-related, or other clinically documented complications requiring treatment, monitoring, ICU care, reoperation, or other medical intervention. Complications will be identified from anesthesia records, surgical records, ICU charts, laboratory and imaging results, discharge summaries, and hospital medical records. This outcome will be used to evaluate the prognostic performance of P-POSSUM and frailty-enhanced risk prediction.

  Within 30 days after surgery or until hospital discharge, whichever occurs first

Secondary Outcomes (5)

• All-cause mortality within 30 days after abdominal surgery

  Within 30 days after surgery or until hospital discharge, whichever occurs first

• Discrimination of P-POSSUM for postoperative complications

  Postoperative complications occurring from the end of surgery through 30 days after surgery or hospital discharge, whichever occurs first.

• Incremental discrimination of frailty-related variables added to P-POSSUM

  Postoperative complications occurring from the end of surgery through 30 days after surgery or hospital discharge, whichever occurs first.

• Intensive care unit length of stay

  From ICU admission until ICU discharge or death, assessed up to 30 days after ICU admission.

• Hospital length of stay

  From hospital admission until hospital discharge or in-hospital death, assessed up to 90 days after hospital admission.

Study Arms (1)

Abdominal Surgery Cohort

Adult patients undergoing abdominal surgery at Bach Mai Hospital who meet the study eligibility criteria. Participants will be identified from retrospective records from January 2025 and prospectively collected data through May 2026. No intervention will be assigned by the investigators. P-POSSUM physiological and operative variables, frailty-related variables, routine perioperative clinical data, postoperative complications, and treatment outcomes will be collected to evaluate prognostic performance and risk prediction.

Eligibility Criteria

• Age: 60 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Older adult patients aged 60 years or older undergoing abdominal surgery at Bach Mai Hospital. The study population includes patients identified from retrospective hospital records from January 2025 and prospectively collected data through May 2026. P-POSSUM variables, frailty-related variables, routine perioperative clinical data, postoperative complications, and treatment outcomes will be collected for prognostic evaluation.

You may qualify if:

• Patients aged 60 years or older. Patients undergoing abdominal surgery at Bach Mai Hospital. Patients managed perioperatively or postoperatively by the Center for Anesthesia and Surgical Intensive Care.
• Patients with available perioperative clinical data required to calculate the P-POSSUM score.
• Patients with available baseline clinical, comorbidity, or functional status information for frailty assessment.
• Patients with available postoperative outcome data for assessment of complications, mortality, or treatment outcomes.

You may not qualify if:

• Patients younger than 60 years. Patients not undergoing abdominal surgery. Patients undergoing minor procedures without operative severity data required for P-POSSUM calculation.
• Patients with missing key physiological or operative variables required to calculate the P-POSSUM score.
• Patients with insufficient baseline information for frailty assessment. Patients with insufficient postoperative follow-up data for outcome assessment.

Sponsors & Collaborators

• Bach Mai Hospital: lead

Study Sites (1)

Bach Mai Hospital, Hanoi, Viet Nam.

Hanoi, Hanoi, 00000, Vietnam

Location

MeSH Terms

Conditions

Postoperative Complications; Frailty

Condition Hierarchy (Ancestors)

Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: OTHER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator, Director, Center for Anesthesia and Surgical Intensive Care

Study Record Dates

• First Submitted: June 16, 2026
• First Posted: June 25, 2026
• Study Start: January 1, 2026
• Primary Completion: June 30, 2026
• Study Completion: June 30, 2026
• Last Updated: June 25, 2026

Record last verified: 2026-06

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP, ANALYTIC CODE
• Time Frame: De-identified individual participant data and supporting documents will be available after publication of the main study results. There is no predetermined end date for data availability; requests will be considered according to institutional policies, ethics requirements, and data sharing agreements.
• Access Criteria: Data may be shared with qualified researchers for systematic reviews, meta-analyses, external validation, or scientifically valid secondary analyses. Access will require submission of a research proposal, approval by an ethics committee when applicable, and a signed data sharing agreement with the study custodian or sponsor. Requests should be sent to the study contact. Shared data will be de-identified and limited to variables necessary for the approved analysis.

Locations

VN (1)