Association Between Frailty and Postoperative Adverse Outcomes in Patients Undergoing Urological Surgery

NCT05871879 | Completed

• 1 other identifier: 202305015
• Study Type: observational
• Target: 317,076
• Locations: 1 country
• Sites: 1

Brief Summary

Frailty is a clinical condition associated with aging that is characterized by a decline in physiological capacity involving multiple organ systems. Previous research has established a strong correlation between frailty and increased mortality and morbidity risk after surgery. The 5-item modified frailty index (mFI-5) is a recent tool used to assess frailty. The aim of the present study was to use the mFI-5 to identify frailty and its association with postoperative adverse outcomes, including mortality and morbidity, among patients who underwent urologic procedures.

Conditions

Frailty; Postoperative Complications

Keywords

Frailty; Postoperative Complications; Urologic Surgery

Outcome Measures

Primary Outcomes (1)

• postoperative mortality

  postoperative in-hospital mortality

  within 30 days after the primary procedure

Secondary Outcomes (1)

• postoperative complications

  within 30 days after the primary procedure

Study Arms (1)

All adult patients who underwent urologic procedures

The included procedures included all urologic oncology surgeries, suburethral sling placement, laparoscopic pyeloplasty, transurethral resection of the prostate, transurethral resection of the bladder tumor, ureteroscopy, hydrocelectomy, orchiectomy, spermatocelectomy, epididymectomy, and varicocelectomy.

Diagnostic Test: The 5-item modified frailty index

Interventions

The 5-item modified frailty index DIAGNOSTIC_TEST

The mFI-5 contains five items, including hypertension, diabetes, congestive heart failure (CHF), chronic obstructive lung disease (COPD), and physical function status, with each item attributing 1 point. Patients with an mFI-5 score greater than or equal to 2 were considered frail, while those with an mFI-5 score of 0 or 1 were considered nonfrail.

Also known as: mFI-5

All adult patients who underwent urologic procedures

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Surgical cases from 2015 to 2020 NSQIP dataset

You may qualify if:

• All adult patients who underwent urologic procedures were recruited
• (Included procedures : all urologic oncology surgeries, suburethral sling placement and laparoscopic pyeloplasty, transurethral resection of the prostate, transurethral resection of the bladder tumor, ureteroscopy, hydrocelectomy, orchiectomy, spermatocelectomy, epididymectomy, and varicocelectomy.)

You may not qualify if:

• Incomplete information of baseline parameters

Sponsors & Collaborators

• Taipei Medical University Hospital: lead

Study Sites (1)

Taipei Medical University Hospital

Taipei, 110, Taiwan

Location

MeSH Terms

Conditions

Frailty; Postoperative Complications

Condition Hierarchy (Ancestors)

Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Chao-Shun Lin, PhD

  Department of Anesthesiology, Taipei Medical University Hospital, 252 Wuxing St., Taipei 110 Taiwan

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Attending physician of anesthesiology, clinical professor

Study Record Dates

• First Submitted: May 15, 2023
• First Posted: May 23, 2023
• Study Start: January 1, 2023
• Primary Completion: March 16, 2023
• Study Completion: May 15, 2023
• Last Updated: May 23, 2023

Record last verified: 2023-05

Locations

TW (1)