Predictive Value of Frailty Scores and Admission Laboratory Markers for Postoperative ICU Mortality

NCT07279519 | Not Yet Recruiting

• 1 other identifier: MEAH-GER-ICU-2025-01
• Study Type: observational
• Target: 300
• Locations: 1 country
• Sites: 1

Brief Summary

This prospective observational study aims to evaluate the predictive value of the Clinical Frailty Scale (CFS), the Katz Activities of Daily Living (ADL) scale, and admission laboratory markers for postoperative mortality among geriatric patients admitted to the intensive care unit (ICU) after surgery. Frailty assessment and functional status are increasingly recognized as determinants of outcomes in older adults, yet their combined predictive power with routine laboratory parameters at ICU admission remains unclear. By systematically collecting clinical scores and laboratory data at the time of ICU admission, this study seeks to identify early predictors of mortality and support risk-stratification in geriatric postoperative patients.

Conditions

Postoperative Mortality; Frailty at Older Adults; Activities of Daily Living; Postoperative Complications

Keywords

Frailty; ICU Mortality; Geriatric Surgery

Outcome Measures

Primary Outcomes (1)

• 30-day ICU Mortality

  Mortality status will be determined at the time of ICU discharge. Mortality is defined as all-cause death occurring during the postoperative ICU stay. Data will be collected prospectively from the electronic medical record and verified by the ICU clinical team. The outcome will be recorded as a binary variable (survived / died)

  30 days after ICU admission

Secondary Outcomes (2)

• Rate of ICU Length of Stay in Geriatric Postoperative Patients

  From ICU admission to ICU discharge (up to 28 days)

• Association Between Laboratory Markers and Frailty Scores

  At ICU admission

Study Arms (1)

Geriatric Postoperative ICU Cohort

This cohort includes geriatric patients (≥65 years) admitted to the intensive care unit after surgery. All participants are followed prospectively to evaluate clinical frailty, functional status, and admission laboratory parameters in relation to postoperative ICU mortality.

Eligibility Criteria

• Age: 65 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

This study will include geriatric patients aged 65 years and older who have undergone elective or emergency surgery and require postoperative monitoring in the intensive care unit for at least 24 hours. Patients must provide informed consent personally or through a legally authorized representative

You may qualify if:

• Individuals aged 65 years and older Undergoing elective or emergency surgery Monitored in the intensive care unit for at least 24 hours after surgery Provision of informed consent by the patient or the legal representative

You may not qualify if:

• Patients with incomplete or unavailable data sets ICU stays shorter than 24 hours Patients admitted for organ transplantation or those in the terminal stage receiving palliative care

Sponsors & Collaborators

• Malatya Egitim Ve Arastirma Hastanesi: lead

Study Sites (1)

Malatya Eğitim Araştırma Hastanesi

Malatya, 44000, Turkey (Türkiye)

Location

Related Publications (3)

• Hanci P, Temel E, Bilir F, Kaya BS. Lactate to albumin ratio as a determinant of intensive care unit admission and mortality in hospitalized patients with community-acquired pneumonia. BMC Pulm Med. 2025 May 9;25(1):224. doi: 10.1186/s12890-025-03698-7.

  PMID: 40346545 RESULT

• Moisi L, Mino JC, Guidet B, Vallet H. Frailty assessment in critically ill older adults: a narrative review. Ann Intensive Care. 2024 Jun 18;14(1):93. doi: 10.1186/s13613-024-01315-0.

  PMID: 38888743 RESULT

• Chen W, Chen M, Qiao X. Interaction of lactate/albumin and geriatric nutritional risk index on the all-cause mortality of elderly patients with critically ill heart failure: A cohort study. Clin Cardiol. 2023 Jul;46(7):745-756. doi: 10.1002/clc.24029. Epub 2023 May 24.

  PMID: 37226575 RESULT

MeSH Terms

Conditions

Postoperative Complications; Frailty

Condition Hierarchy (Ancestors)

Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Leman Acun Delen, MD, Assoc. Prof.

  Malatya Training and Research Hospital, Department of Anesthesiology and Intensive Care

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Leman Acun Delen, Assoc. Prof. of Anesthesiology

CONTACT

+905337132824; lmndelen@hotmail.com

Leman acun delen, MD, Assoc. Prof.

CONTACT

+905337132824; lmndelen@hotmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor of Anesthesiology and İntensive Care

Study Record Dates

• First Submitted: November 26, 2025
• First Posted: December 12, 2025
• Study Start: January 15, 2026
• Primary Completion: April 30, 2026
• Study Completion (Estimated): June 30, 2026
• Last Updated: December 12, 2025

Record last verified: 2025-12

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)