Mortality Predictors in Patients 80+ After Major Abdominal Surgery: Role of Frailty and Physiological Reserve

NCT07440095 | Completed

• 1 other identifier: 2026-02/31
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study is to identify independent risk factors for 30-day mortality in patients aged 80 and over who have undergone major abdominal surgery. While traditional risk scoring systems often focus on chronic disease burden, they may not fully capture the biological decline associated with aging. This research specifically focuses on the predictive value of "frailty" and "physiological reserve" in determining surgical outcomes for this "old-old" patient population. In this retrospective cohort study, data from approximately 200 patients treated between 2022 and 2025 will be analyzed. Frailty will be assessed using the Modified Frailty Index (mFI-5), and physiological reserve will be evaluated through preoperative laboratory markers such as albumin, creatinine, and lymphocyte counts. By determining how these factors influence postoperative mortality, the study aims to improve preoperative patient selection, enhance risk communication with families, and provide a basis for protective strategies like prehabilitation.

Conditions

Abdomen Cancer; Frailty; Postoperative Complications; Aged, 80 and Over

Outcome Measures

Primary Outcomes (1)

• 30-Day Postoperative Mortality

  The occurrence of death from any cause within 30 days following the major abdominal surgical procedure. This will be assessed using hospital electronic records and, if necessary, through telephone follow-ups with patients or their relatives.

  From the date of surgery up to 30 days postoperatively

Secondary Outcomes (4)

• Modified Frailty Index (mFI-5) Score

  Preoperative assessment (retrospective data from 2022-2025)

• Preoperative Serum Albumin Level

  Preoperative laboratory values collected retrospectively from 2022-2025.

• Preoperative Serum Creatinine Level

  Preoperative laboratory values collected retrospectively from 2022-2025.

• Preoperative Hemoglobin Level

  Preoperative laboratory values collected retrospectively from 2022-2025

Interventions

Major Abdominal Surgery and Frailty Assessment OTHER

Retrospective evaluation of patients aged 80 and over who underwent major abdominal surgery (including surgical oncology, gynecologic oncology, and urologic oncology). The study involves the assessment of preoperative frailty using the Modified Frailty Index (mFI-5) and the analysis of physiological reserve through laboratory markers (albumin, creatinine, lymphocyte count, hemoglobin). The primary focus is to determine the impact of these factors on 30-day postoperative mortality.

Eligibility Criteria

• Age: 80 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study population consists of "old-old" patients (aged 80 years and older) who underwent major abdominal surgery at a tertiary oncology center (Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital) between January 2022 and December 2025. This population includes patients who received surgical interventions in the departments of surgical oncology, gynecologic oncology, and urologic oncology. The sample represents a high-risk geriatric group undergoing complex oncological or major abdominal procedures, where frailty and physiological reserve are critical factors for survival.

You may qualify if:

• Patients aged 80 years and older
• Underwent major abdominal surgery between January 2022 and December 2025
• Availability of at least 30 days of postoperative follow-up data
• Complete medical records available in the hospital information system

You may not qualify if:

• Patients under 80 years of age
• Underwent surgical procedures other than major abdominal surgery
• Missing or incomplete follow-up data within the first 30 days postoperatively
• Insufficient data for the assessment of frailty (mFI-5) or physiological reserve parameters (e.g., missing preoperative laboratory values)

Sponsors & Collaborators

• Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital: lead

Study Sites (1)

Dr. Abdurrahman Yurtaslan Ankara Oncology Education and Research Hospital Clinic of Anesthesiology and Rea

Ankara, Yenimahalle, 06200, Turkey (Türkiye)

Location

Related Publications (3)

• Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J, Seeman T, Tracy R, Kop WJ, Burke G, McBurnie MA; Cardiovascular Health Study Collaborative Research Group. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci. 2001 Mar;56(3):M146-56. doi: 10.1093/gerona/56.3.m146.

  PMID: 11253156 BACKGROUND

• Makary MA, Segev DL, Pronovost PJ, Syin D, Bandeen-Roche K, Patel P, Takenaga R, Devgan L, Holzmueller CG, Tian J, Fried LP. Frailty as a predictor of surgical outcomes in older patients. J Am Coll Surg. 2010 Jun;210(6):901-8. doi: 10.1016/j.jamcollsurg.2010.01.028. Epub 2010 Apr 28.

  PMID: 20510798 BACKGROUND

• Clegg A, Young J, Iliffe S, Rikkert MO, Rockwood K. Frailty in elderly people. Lancet. 2013 Mar 2;381(9868):752-62. doi: 10.1016/S0140-6736(12)62167-9. Epub 2013 Feb 8.

  PMID: 23395245 BACKGROUND

MeSH Terms

Conditions

Frailty; Postoperative Complications

Condition Hierarchy (Ancestors)

Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Specialist Doctor, Anesthesiology and Reanimation

Study Record Dates

• First Submitted: February 20, 2026
• First Posted: February 27, 2026
• Study Start: March 1, 2026
• Primary Completion: April 1, 2026
• Study Completion: April 10, 2026
• Last Updated: April 30, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)