The Effects of Anesthesia Type on the Prognosis of Hip Fracture Surgery on Elderly Patients

NCT03116490 | Recruiting DMC

• 1 other identifier: RAGA-PHP
• Study Type: observational
• Target: 600
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study is to figure out whether anesthesia type have an influence on the prognosis of hip fracture surgery.30-day mortality and morbidity after the surgery are our main observational index,and according to literature and our experience,regional anesthesia may have a better prognosis after hip fracture surgery compared with general anesthesia.

Conditions

Postoperative Complications; Postoperative Mortality

Keywords

morbidity; mortality; hip fracture; anesthesia type; POSSUM

Outcome Measures

Primary Outcomes (1)

• Mortality

  30-day after surgery

Secondary Outcomes (2)

• Morbidity

  30-day after surgery

• VAS pain score

  everyday after surgery,record for 7 days

Other Outcomes (1)

• The Orthopedic POSSUM score

  baseline

Study Arms (2)

group RA

the anesthesia type for patients with hip fracture surgery is regional anesthesia

Procedure: Anesthesia type

group GA

the anesthesia type for patients with hip fracture surgery is general anesthesia

Procedure: Anesthesia type

Interventions

Anesthesia type PROCEDURE

RA group uses regional anesthesia(epidural, spinal, combined spinal and epidural anesthesia or nerve block) ,and GA group uses general anesthesia(general anesthesia combined with peripheral nerve blockade, general anesthesia combined with spinal/epidural anesthesia or single general anesthesia) .

group GA; group RA

Eligibility Criteria

• Age: 60 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

elderly patients experiencing hip fracture surgery.

You may qualify if:

• Patients with hip fracture;
• Need surgery;
• Anesthesia type is regional anesthesia or general anesthesia;
• Age≥60 years.

You may not qualify if:

• Choosing conservative treatment;
• Other types of anesthesia or without anesthesia.

Sponsors & Collaborators

• Wenzhou Medical University: lead

Study Sites (1)

WenZhou Medical University Second Affiliated Hospital

Wenzhou, Zhejiang, 325000, China

RECRUITING

Related Publications (22)

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  PMID: 18171955 BACKGROUND

• Johnell O, Kanis JA. An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. Osteoporos Int. 2006 Dec;17(12):1726-33. doi: 10.1007/s00198-006-0172-4. Epub 2006 Sep 16.

  PMID: 16983459 BACKGROUND

• Brauer CA, Coca-Perraillon M, Cutler DM, Rosen AB. Incidence and mortality of hip fractures in the United States. JAMA. 2009 Oct 14;302(14):1573-9. doi: 10.1001/jama.2009.1462.

  PMID: 19826027 BACKGROUND

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  PMID: 16809710 BACKGROUND

• Beaupre LA, Jones CA, Saunders LD, Johnston DW, Buckingham J, Majumdar SR. Best practices for elderly hip fracture patients. A systematic overview of the evidence. J Gen Intern Med. 2005 Nov;20(11):1019-25. doi: 10.1111/j.1525-1497.2005.00219.x.

  PMID: 16307627 BACKGROUND

• Neuman MD, Archan S, Karlawish JH, Schwartz JS, Fleisher LA. The relationship between short-term mortality and quality of care for hip fracture: a meta-analysis of clinical pathways for hip fracture. J Am Geriatr Soc. 2009 Nov;57(11):2046-54. doi: 10.1111/j.1532-5415.2009.02492.x. Epub 2009 Sep 28.

  PMID: 19793159 BACKGROUND

• Vestergaard P, Rejnmark L, Mosekilde L. Loss of life years after a hip fracture. Acta Orthop. 2009 Oct;80(5):525-30. doi: 10.3109/17453670903316835.

  PMID: 19916683 BACKGROUND

• Vochteloo AJ, Borger van der Burg BL, Roling MA, van Leeuwen DH, van den Berg P, Niggebrugge AH, de Vries MR, Tuinebreijer WE, Bloem RM, Nelissen RG, Pilot P. Contralateral hip fractures and other osteoporosis-related fractures in hip fracture patients: incidence and risk factors. An observational cohort study of 1,229 patients. Arch Orthop Trauma Surg. 2012 Aug;132(8):1191-7. doi: 10.1007/s00402-012-1520-9. Epub 2012 Apr 24.

  PMID: 22526197 BACKGROUND

• Parker MJ, Handoll HH, Griffiths R. Anaesthesia for hip fracture surgery in adults. Cochrane Database Syst Rev. 2001;(4):CD000521. doi: 10.1002/14651858.CD000521.

  PMID: 11687085 BACKGROUND

• O'Hara DA, Duff A, Berlin JA, Poses RM, Lawrence VA, Huber EC, Noveck H, Strom BL, Carson JL. The effect of anesthetic technique on postoperative outcomes in hip fracture repair. Anesthesiology. 2000 Apr;92(4):947-57. doi: 10.1097/00000542-200004000-00011.

  PMID: 10754613 BACKGROUND

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  PMID: 11118174 BACKGROUND

• Neuman MD, Silber JH, Elkassabany NM, Ludwig JM, Fleisher LA. Comparative effectiveness of regional versus general anesthesia for hip fracture surgery in adults. Anesthesiology. 2012 Jul;117(1):72-92. doi: 10.1097/ALN.0b013e3182545e7c.

  PMID: 22713634 BACKGROUND

• Neuman MD, Rosenbaum PR, Ludwig JM, Zubizarreta JR, Silber JH. Anesthesia technique, mortality, and length of stay after hip fracture surgery. JAMA. 2014 Jun 25;311(24):2508-17. doi: 10.1001/jama.2014.6499.

  PMID: 25058085 BACKGROUND

• Patorno E, Neuman MD, Schneeweiss S, Mogun H, Bateman BT. Comparative safety of anesthetic type for hip fracture surgery in adults: retrospective cohort study. BMJ. 2014 Jun 27;348:g4022. doi: 10.1136/bmj.g4022.

  PMID: 24972901 BACKGROUND

• Owens WD, Felts JA, Spitznagel EL Jr. ASA physical status classifications: a study of consistency of ratings. Anesthesiology. 1978 Oct;49(4):239-43. doi: 10.1097/00000542-197810000-00003.

  PMID: 697077 BACKGROUND

• Copeland GP, Jones D, Walters M. POSSUM: a scoring system for surgical audit. Br J Surg. 1991 Mar;78(3):355-60. doi: 10.1002/bjs.1800780327.

  PMID: 2021856 BACKGROUND

• Brunelli A, Fianchini A, Xiume F, Gesuita R, Mattei A, Carle F. Evaluation of the POSSUM scoring system in lung surgery. Physiological and Operative Severity Score for the enUmeration of Mortality and Morbidity. Thorac Cardiovasc Surg. 1998 Jun;46(3):141-6. doi: 10.1055/s-2007-1010211.

  PMID: 9714489 BACKGROUND

• Gotohda N, Iwagaki H, Itano S, Horiki S, Fujiwara T, Saito S, Hizuta A, Isozaki H, Takakura N, Terada N, Tanaka N. Can POSSUM, a scoring system for perioperative surgical risk, predict postoperative clinical course? Acta Med Okayama. 1998 Dec;52(6):325-9. doi: 10.18926/AMO/31304.

  PMID: 9876770 BACKGROUND

• Tekkis PP, Kocher HM, Bentley AJ, Cullen PT, South LM, Trotter GA, Ellul JP. Operative mortality rates among surgeons: comparison of POSSUM and p-POSSUM scoring systems in gastrointestinal surgery. Dis Colon Rectum. 2000 Nov;43(11):1528-32, discusssion 1532-4. doi: 10.1007/BF02236732.

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  PMID: 12188495 BACKGROUND

• Wright DM, Blanckley S, Stewart GJ, Copeland GP. The use of orthopaedic POSSUM as an audit tool for fractured neck of femur. Injury. 2008 Apr;39(4):430-5. doi: 10.1016/j.injury.2007.11.009. Epub 2008 Mar 7.

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  PMID: 13731759 BACKGROUND

Related Links

• The second Affiliated Hospital \& Yuying Children hospital of Wenzhou Medical University

MeSH Terms

Conditions

Postoperative Complications; Hip Fractures

Condition Hierarchy (Ancestors)

Pathologic Processes; Pathological Conditions, Signs and Symptoms; Femoral Fractures; Fractures, Bone; Wounds and Injuries; Hip Injuries; Leg Injuries

Study Officials

• Ting Li, M.D.

  The Second Affiliated Hospital & Yuying Children hospital of Wenzhou Medical University

  STUDY CHAIR

• Yahe Ge, Medical Student

  The Second Affiliated Hospital & Yuying Children hospital of Wenzhou Medical University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Ting Li, M.D.

CONTACT

00447570150148; liting1021@aliyun.com

Yahe Ge, Medical Student

CONTACT

008615330056542; 770736428@qq.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Director,Associate chief physician of Anesthesia Department

Study Record Dates

• First Submitted: January 14, 2017
• First Posted: April 17, 2017
• Study Start: January 16, 2026
• Primary Completion (Estimated): December 1, 2026
• Study Completion (Estimated): December 1, 2028
• Last Updated: July 24, 2024

Record last verified: 2024-07

Locations

CN (1)