Rhomboid Intercostal Sub-serratus Plane Block Versus External Oblique Intercostal Block in Open Nephrectomy

NCT07642193 | Recruiting

• 1 other identifier: AP2604-501-160-209
• Study Type: interventional
• Target: 90
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to compare time of first request of analgesia among patients undergoing rhomboid intercostal sub-serratus plane block versus external oblique intercostal block for perioperative pain management in open nephrectomy.

Conditions

Rhomboid Intercostal Sub-serratus Plane Block; External Oblique Intercostal Block; Open Nephrectomy

Outcome Measures

Primary Outcomes (1)

• Time of first request of analgesia

  Time of first request of analgesia will be recorded from the end of surgery till first dose of morphine administrated.

  24 hours postoperatively

Secondary Outcomes (6)

• Heart rate

  24 hours postoperatively

• Mean arterial blood pressure

  24 hours postoperatively

• Total amount of fentanyl

  24 hours postoperatively

• Total morphine consumption

  24 hours postoperatively

• Degree of pain

  24 hours postoperatively

Study Arms (3)

Group (A)

EXPERIMENTAL

Patients will receive the rhomboid intercostal subserratus plane block.

Other: Rhomboid intercostal subserratus plane block

Group (B)

EXPERIMENTAL

Patients will receive the external oblique intercostal block.

Other: External oblique intercostal block

Control group

ACTIVE COMPARATOR

Patients will not receive any interventions (IV morphine 0.1mg/kg after induction of general anesthesia).

Drug: Intravenous morphine

Interventions

Rhomboid intercostal subserratus plane block OTHER

Patients will receive the rhomboid intercostal subserratus plane block.

Group (A)

Intravenous morphine DRUG

Patients will not receive any interventions (Intravenous morphine 0.1mg/kg after induction of general anesthesia).

Control group

External oblique intercostal block OTHER

Patients will receive the external oblique intercostal block.

Group (B)

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Both sexes.
• American Society of Anesthesiologists (ASA) physical status II, III.
• Body mass index (BMI): \> 20 kg/ m2 and \< 35 kg/ m2.
• Patients undergoing open nephrectomy.

You may not qualify if:

• Patient refusal.
• BMI \<20 kg/m2 and \>35 kg/m2
• Known sensitivity or contraindication to drug used in the study (local anesthetics, opioids).
• History of psychiatric and cognitive disorders or chronic pain.
• Contraindication to regional anesthesia e.g pre- existing peripheral neuropathies.
• Severe respiratory or cardiac disorders.
• Advanced liver or kidney disease.
• Pregnancy.
• Physical status ASA IV.
• Coagulopathy with INR ≥ 1.6: hereditary (e.g. hemophilia, fibrinogen abnormalities \& deficiency of factor II) - acquired (e.g. impaired liver functions with prothrombin concentration less than 60 %, vitamin K deficiency \& therapeutic anticoagulants drugs).

Sponsors & Collaborators

• Cairo University: lead

Study Sites (1)

Cairo University

Cairo, 12613, Egypt

RECRUITING

Central Study Contacts

Amr R Seif, MD

CONTACT

00201066588692; amroseifo40404@gmail.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Lecturer of Anesthesia, ICU and Pain Management, Faculty of Medicine, National Cancer Institute, Cairo, Egypt.

Study Record Dates

• First Submitted: June 7, 2026
• First Posted: June 11, 2026
• Study Start: May 2, 2026
• Primary Completion (Estimated): December 30, 2026
• Study Completion (Estimated): December 30, 2026
• Last Updated: June 11, 2026

Record last verified: 2026-06

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL
• Time Frame: After the end of study for one year.
• Access Criteria: The data will be available upon a reasonable request from the corresponding author.

Locations

EG (1)