Modified External Oblique Intercostal Plane Block Versus Erector Spinae Plane Block for Open Nephrectomy

NCT07726550 | Not Yet Recruiting

• 1 other identifier: TNKU-EOIPB003
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

This prospective, randomized, assessor-blinded clinical trial aims to compare the postoperative analgesic efficacy of ultrasound-guided Erector Spinae Plane Block (ESPB) and Modified External Oblique Intercostal Plane Block (EOIPB) in patients undergoing elective open nephrectomy under general anesthesia. Sixty adult patients will be randomized to receive either ESPB or EOIPB before surgical incision. All participants will receive standardized general anesthesia and postoperative multimodal analgesia. Postoperative pain scores, opioid consumption, rescue analgesic requirements, and postoperative nausea and vomiting will be assessed during the first 24 hours after surgery. The study aims to determine whether one fascial plane block technique provides superior postoperative pain control and recovery following open nephrectomy.

Conditions

Postoperative Pain; Open Nephrectomy

Keywords

Erector Spinae Plane Block; External Oblique Intercostal Plane Block; Regional Anesthesia; EOIPB; ESPB; Postoperative Analgesia; Open Nephrectomy; Multimodal Analgesia; Pain Management

Outcome Measures

Primary Outcomes (1)

• Pain intensity at rest

  Postoperative pain intensity will be assessed at rest using the 11-point Numeric Rating Scale, ranging from 0 to 10, where 0 indicates no pain and 10 indicates the worst imaginable pain. Higher scores indicate greater pain intensity.

  0, 2, 6, 12, and 24 hours after surgery

Secondary Outcomes (6)

• Pain intensity during movement

  0, 2, 6, 12, and 24 hours after surgery

• Total Opioid Consumption

  24 hours after surgery

• Rescue Analgesic Requirement

  24 hours after surgery

• Postoperative Nausea and Vomiting

  24 hours after surgery

• Heart Rate

  From induction of anesthesia until the end of surgery

Study Arms (2)

ESPB Group

EXPERIMENTAL

Participants will receive an ultrasound-guided erector spinae plane block with 30 mL of 0.25% bupivacaine after induction of general anesthesia and before surgical incision. Standardized general anesthesia and postoperative multimodal analgesia will be provided to all participants.

Procedure: Erector Spinae Plane Block

EOIPB Group

EXPERIMENTAL

Participants will receive an ultrasound-guided modified external oblique intercostal plane block with 30 mL of 0.25% bupivacaine after induction of general anesthesia and before surgical incision. Standardized general anesthesia and postoperative multimodal analgesia will be provided to all participants.

Procedure: Modified External Oblique Intercostal Plane Block

Interventions

Modified External Oblique Intercostal Plane Block PROCEDURE

Ultrasound-guided modified external oblique intercostal plane block performed after induction of general anesthesia using 30 mL of 0.25% bupivacaine before surgical incision.

EOIPB Group

Erector Spinae Plane Block PROCEDURE

Ultrasound-guided erector spinae plane block performed after induction of general anesthesia using 30 mL of 0.25% bupivacaine before surgical incision.

ESPB Group

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age between 18 and 65 years.
• American Society of Anesthesiologists (ASA) physical status I or II.
• Scheduled for elective open nephrectomy.
• Able and willing to provide written informed consent.
• Willing to comply with study procedures.

You may not qualify if:

• Refusal to participate or inability to provide informed consent.
• Emergency surgery.
• Body mass index (BMI) greater than 35 kg/m².
• Known allergy or hypersensitivity to local anesthetics.
• Infection at the planned block insertion site.
• Coagulopathy or ongoing anticoagulant therapy.
• Pregnancy or breastfeeding.
• Prisoners or other vulnerable populations unable to provide independent consent.

Sponsors & Collaborators

• Namik Kemal University: lead

Study Sites (1)

Tekirdağ Namık Kemal University

Tekirdağ, Tekirdağ, 59000, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Pain, Postoperative; Agnosia

Condition Hierarchy (Ancestors)

Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Pain; Neurologic Manifestations; Signs and Symptoms; Perceptual Disorders; Neurobehavioral Manifestations; Nervous System Diseases

Central Study Contacts

Onur Baran, MD

CONTACT

+90 539 342 25 82; dronurbaran@hotmail.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Masking Details: Participants will be unaware of group allocation because all block procedures will be performed after induction of general anesthesia. Postoperative outcome assessments will be conducted by a researcher who is blinded to treatment allocation.
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor of Anesthesiology and Reanimation

Model Details: Participants will be randomized in a 1:1 ratio to receive either ultrasound-guided erector spinae plane block (ESPB) or modified external oblique intercostal plane block (EOIPB) before surgical incision. Both groups will receive standardized general anesthesia and postoperative multimodal analgesia.

Study Record Dates

• First Submitted: June 22, 2026
• First Posted: July 24, 2026
• Study Start: August 1, 2026
• Primary Completion (Estimated): February 1, 2027
• Study Completion (Estimated): February 1, 2027
• Last Updated: July 24, 2026

Record last verified: 2026-07

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)