Effectiveness of Resistance Exercises Added to Aerobic and Balance Exercises in Parkinson's Disease

NCT07629063 | Active Not Recruiting

• 1 other identifier: 3103 / 05.08.2025
• Study Type: interventional
• Target: 34
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to evaluate the effects of resistive exercises added to aerobic and balance exercises on quality of life, activities of daily living, cognitive functions, and sarcopenia parameters in patients diagnosed with early-stage PD. The main question it aims to answer is: In patients diagnosed with early-stage Parkinson's disease, do resistive exercises added to aerobic and balance exercises have an effect on quality of life, daily living activities, cognitive function, and sarcopenia parameters? If so, what is the nature of this effect? Patients will undergo an exercise program three days a week for eight weeks. Outcomes will be assessed at baseline, on the first day after the treatment and 4 weeks after the end of the treatment.

Conditions

Parkinson's Disease (PD); Sarcopenia

Keywords

Parkinson's Disease; Sarcopenia; Exercise

Outcome Measures

Primary Outcomes (3)

• Grip strenght

  Grip strength is measured using a hydraulic hand dynamometer with the dominant hand.

  Baseline (pre-treatment), Day 1 post-treatment, Week 4 post-treatment

• Chair Stand Test

  Chair Stand Test is used to assess muscle function. Patients asked to sit and stand on a chair for 5 times.

  Baseline (pre-treatment), Day 1 post-treatment, Week 4 post-treatment

• Gait Speed

  Gait speed is assessed by measuring the time it takes the patient to walk a distance of 4 meters.

  Baseline (pre-treatment), Day 1 post-treatment, Week 4 post-treatment

Secondary Outcomes (9)

• Quadriceps Muscle Thickness Measurement

  Baseline (pre-treatment), Day 1 post-treatment, Week 4 post-treatment

• Time-Up And Go Test

  Baseline (pre-treatment), Day 1 post-treatment, Week 4 post-treatment

• SARC-F Questionnaire

  Baseline (pre-treatment), Day 1 post-treatment, Week 4 post-treatment

• The Short Physical Performance Battery (SPPB)

  Baseline (pre-treatment), Day 1 post-treatment, Week 4 post-treatment

• Berg Balance Scale

  Baseline (pre-treatment), Day 1 post-treatment, Week 4 post-treatment

Study Arms (2)

Aerobic and Balance Exercise Group

ACTIVE COMPARATOR

Participants will receive an exercise program with 3 days a week for 8 weeks. Each treatment session will not exceed 45 minutes. Program will include aerobic exercises with 15 minutes on a treadmill, aiming not to exceed 85% of maximum heart rate and balance exercises including tandem stance, tandem walk, side stepping, backward walking, single leg stance.

Other: Exercise

Aerobic, Balance and Resistive Exercise Group

EXPERIMENTAL

Participants will receive an exercise program with 3 days a week for 8 weeks. Each treatment session will not exceed 45 minutes. Program will include aerobic exercises with 15 minutes on a treadmill, aiming not to exceed 85% of maximum heart rate; balance exercises including tandem stance, tandem walk, side stepping, backward walking, single leg stance and resistive exercises for upper and lower extremity

Other: Exercise

Interventions

Exercise OTHER

An 3 days a week for 8 weeks aerobic and balance exercises program

Also known as: Aerobic and Balance Exercises

Aerobic and Balance Exercise Group

Eligibility Criteria

• Age: 40 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Adults aged 40 to 70 years
• Patients diagnosed with Modified Hoehn-Yahr stage 1-3 Parkinson's disease
• Patients diagnosed with Parkinson's disease for more than 1 year
• Patients who can mobilize without an assistive device

You may not qualify if:

• Patients diagnosed with Parkinson Plus syndrome
• History of uncontrolled hypertension
• History of uncontrolled diabetes mellitus
• History of serebrovascular disease within the past 6 months
• History of miyocardial infarction within the past 6 months
• History of knee or hip artroplasty surgery
• History of severe cardiac arrythmia
• Presence of cardiac pacemaker
• Presence of severe dementia
• History of severe psychiatric disorders
• Patients who have on dialysis
• Presence of acute infection
• Pregnancy
• History of malignancy

Sponsors & Collaborators

• Sisli Hamidiye Etfal Training and Research Hospital: lead

Study Sites (1)

Sisli Hamidiye Etfal Training and Research Hospital

Istanbul, Turkey (Türkiye)

Location

Related Publications (3)

• Leal LC, Abrahin O, Rodrigues RP, da Silva MC, Araujo AP, de Sousa EC, Pimentel CP, Cortinhas-Alves EA. Low-volume resistance training improves the functional capacity of older individuals with Parkinson's disease. Geriatr Gerontol Int. 2019 Jul;19(7):635-640. doi: 10.1111/ggi.13682. Epub 2019 Apr 29.

  PMID: 31037806 BACKGROUND

• Kim R, Choi S, Kang N, Park K, Shin H, Lee H, Lee H, Jun JS, Jeon B, Byun K. Effects of high-intensity interval training and moderate-intensity continuous training on sarcopenia-related parameters in participants with Parkinson's disease: A 24-week randomized pilot trial substudy. Parkinsonism Relat Disord. 2023 Dec;117:105901. doi: 10.1016/j.parkreldis.2023.105901. Epub 2023 Oct 21.

  PMID: 37898016 BACKGROUND

• Vieira de Moraes Filho A, Chaves SN, Martins WR, Tolentino GP, de Cassia Pereira Pinto Homem R, Landim de Farias G, Fischer BL, Oliveira JA, Pereira SKA, Vidal SE, Mota MR, Moreno Lima R, Jaco de Oliveira R. Progressive Resistance Training Improves Bradykinesia, Motor Symptoms and Functional Performance in Patients with Parkinson's Disease. Clin Interv Aging. 2020 Jan 23;15:87-95. doi: 10.2147/CIA.S231359. eCollection 2020.

  PMID: 32158202 BACKGROUND

MeSH Terms

Conditions

Parkinson Disease; Sarcopenia; Motor Activity

Interventions

Exercise

Condition Hierarchy (Ancestors)

Parkinsonian Disorders; Basal Ganglia Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Movement Disorders; Synucleinopathies; Neurodegenerative Diseases; Muscular Atrophy; Neuromuscular Manifestations; Neurologic Manifestations; Atrophy; Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms; Signs and Symptoms; Behavior

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Resident Physician

Model Details: Participants will randomly assigned to one of two exercise based treatment groups. Both groups will receive aerobic and balance exercises, while one group will additionaly receive resistive exercises.

Study Record Dates

• First Submitted: June 1, 2026
• First Posted: June 5, 2026
• Study Start: September 1, 2025
• Primary Completion: June 15, 2026
• Study Completion: June 15, 2026
• Last Updated: June 5, 2026

Record last verified: 2026-06

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)