The Effect of Exercise on Cognitive Functions in Individuals With Systemic Lupus Erythematosus

NCT07622251 | Not Yet Recruiting

• 1 other identifier: E-77300296-050.04-16331
• Study Type: interventional
• Target: 38
• Locations: 1 country
• Sites: 1

Brief Summary

Study Objective: To examine the effect of aerobic exercise on disease activity and cognitive functions in patients diagnosed with SLE. Study Goals:

1. 1.To conduct comprehensive pre- and post-treatment (after 12 weeks) evaluations of SLE patients included in the study, and to determine their disease activity and cognitive levels.
2. 2.To apply aerobic exercise to SLE patients for three months.
3. 3.To analyze the effects of the aerobic exercise program on disease activity and cognitive functions.

Conditions

System Lupus Erythematosus(SLE)

Keywords

cognitive function; aerobic exercise; systemic lupus erythematosus; disease activity

Outcome Measures

Primary Outcomes (1)

• Mini Mental Test

  baseline and 12th week

Secondary Outcomes (6)

• Stroop Test

  baseline and 12th week

• Corsi Block Test

  baseline and 12th week

• Wisconsin Card Sorting Test

  baseline and 12th week

• Six-Minute Walk Test

  baseline and 12th week

• borg scale

  every sessions

Study Arms (2)

Control group

NO INTERVENTION

exercise group

EXPERIMENTAL

Behavioral: Exercise

Interventions

Exercise BEHAVIORAL

Aerobic Exercise + video based games +calisthenics exercise

exercise group

Eligibility Criteria

• Age: 25 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Having been diagnosed with SLE at least one year prior according to the American Rheumatology Association (ACR) diagnostic criteria
• Being between 25-65 years of age
• Not having received a neuropsychiatric diagnosis
• Having medication adjusted and being on stable medication for 3 months
• Not being involved in a regular exercise program
• Having a Mini Mental Test score lower than 26.

You may not qualify if:

• History of secondary rheumatic disease
• Presence of active acute or chronic infection,
• Body mass index (BMI) ≥ 30 kg/m2,
• Acute renal failure,
• Cardiac and pulmonary involvement,
• Presence of musculoskeletal and joint disorders that prevent exercise testing,
• Pregnancy

Sponsors & Collaborators

• Istanbul Galata University: lead
• The Scientific and Technological Research Council of Turkey: collaborator

Study Sites (1)

Istanbul Galata University

Istanbul, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Lupus Erythematosus, Systemic

Interventions

Exercise

Condition Hierarchy (Ancestors)

Connective Tissue Diseases; Skin and Connective Tissue Diseases; Autoimmune Diseases; Immune System Diseases

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Central Study Contacts

nejla uzun

CONTACT

+905076426043; fizyoterapist_nejla@hotmail.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Model Details: Randomized controlled trial

Study Record Dates

• First Submitted: May 10, 2026
• First Posted: June 3, 2026
• Study Start: June 5, 2026
• Primary Completion (Estimated): June 4, 2027
• Study Completion (Estimated): August 10, 2027
• Last Updated: June 3, 2026

Record last verified: 2026-05

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)