Home-based Progressive Resistance Exercise to Enhance Physical Performance of Older Adults With Possible Sarcopenia

NCT04851262 | Completed

• 1 other identifier: UW20-868
• Study Type: interventional
• Target: 42
• Locations: 1 country
• Sites: 1

Brief Summary

The overall aim of the proposed project is to improve muscle strength in older adults with possible sarcopenia by promoting home-based progressive resistance exercise. The target population for health talks is community-dwelling older adults. A Three monthly home-visits and weekly phone calls will be made. A waitlist randomised controlled trial will be conducted to evaluate effectiveness, and qualitative feedback will be collected from participants. A pilot study will be conducted first.

Conditions

Sarcopenia

Outcome Measures

Primary Outcomes (1)

• Change in lower-limb muscle strength at 12 weeks from baseline

  Measured by Short Physical Performance Battery (SPPB), higher score indicates better performance

  12 weeks after baseline

Secondary Outcomes (1)

• Change in lower-limb muscle strength at 24 weeks from baseline

  24 weeks after baseline

Other Outcomes (6)

• Change in handgrip strength at 12 weeks from baseline

  12 weeks after baseline

• Change in handgrip strength at 24 weeks from baseline

  24 weeks after baseline

• Status of possible sarcopenia at 12 weeks from baseline

  12 weeks after baseline

Study Arms (2)

Intervention

EXPERIMENTAL

The intervention is a 12-week home-based resistance training programme with phased progression. The intervention will have three phases: (i) an initial phase focused on training the target muscle(s)/movements with minimal or no external weight; (ii) an intermediate phase targeting muscle strength with increased practice resistance; and (iii) an advanced phase targeting the further enhancement of muscle strength by challenging multiple muscle groups. Each phase will involve exercises targeting the trunk, back, hip, upper-limb and lower-limb muscles.

Behavioral: Exercise

Waitlist control

OTHER

The waitlist control participants will start the intervention 12 weeks after the baseline assessment.

Behavioral: Exercise

Interventions

Exercise BEHAVIORAL

The intervention is to be taught by fitness trainer at the participants' home at the start of each phase. The exercise progression model for older adults recommended by the American College of Sports Medicine, which emphasise gradual increments in training load and systematically alter one or more programme components, will be adopted.

Intervention; Waitlist control

Eligibility Criteria

• Age: 65 Years - 89 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Older Adult (65+)

You may qualify if:

• Aged 65-89;
• Possible sarcopenia (defined by AWGS 2019);
• No cognitive impairment (Abbreviated Mental Test score ≥8); and
• No communication problems.

You may not qualify if:

• having engaged in a structured exercise programme in the past 6 months or planning to do so within the intervention period;
• mobility-limiting injury of the hands or lower limbs, surgery or hospitalisation within the intervention period;
• contraindications such as musculoskeletal/cardiorespiratory disorders, or any advanced diseases that inhibit them from exercising.

Sponsors & Collaborators

• The University of Hong Kong: lead

Study Sites (1)

Community

Hong Kong, Hong Kong

Location

MeSH Terms

Conditions

Sarcopenia

Interventions

Exercise

Condition Hierarchy (Ancestors)

Muscular Atrophy; Neuromuscular Manifestations; Neurologic Manifestations; Nervous System Diseases; Atrophy; Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms; Signs and Symptoms

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: April 12, 2021
• First Posted: April 20, 2021
• Study Start: January 1, 2021
• Primary Completion: November 7, 2024
• Study Completion: November 7, 2024
• Last Updated: March 28, 2025

Record last verified: 2025-03

Data Sharing

• IPD Sharing: Will not share

Locations

HK (1)