RDW and RV-PA Coupling in Acute PE

NCT07616557 | Not Yet Recruiting DMC

• 1 other identifier: RDW and RV-PA Coupling in PE
• Study Type: observational
• Target: 190
• Locations: 0 countries
• Sites: N/A

Brief Summary

Prior work linking RDW to echocardiographic findings in PE has largely focused on isolated parameters such as TAPSE or PASP and has rarely incorporated modern measures of RV-PA coupling. Whether admission RDW reflects the integrated RV-PA interaction - and not merely contractility or pressure in isolation - has not been adequately addressed. Establishing this link would support RDW as a simple, universally available marker of RV vulnerability at first presentation, and would lay the groundwork for future prognostic and mechanistic studies.

Conditions

Pulmonary Embolism Acute

Keywords

Embolism; RDW; Right Ventricular-Pulmonary Arterial Coupling

Outcome Measures

Primary Outcomes (1)

• assess the association between admission red cell distribution width (RDW) and right ventricular-pulmonary arterial coupling, measured by TAPSE/PASP ratio on transthoracic echocardiography performed within 24 hours of admission, in adults with acute PE

  To assess the association between admission red cell distribution width (RDW) and right ventricular-pulmonary arterial coupling, measured by the TAPSE/PASP ratio on transthoracic echocardiography performed within 24 h of admission, in adults with acute pulmonary embolism

  24 hours

Study Arms (1)

Acute PE confirmed by computed tomography pulmonary angiogram (CTPA) performed within 24 h

Other: Echo-cardiography

Interventions

Echo-cardiography OTHER

All echocardiograms will follow a standardized acquisition protocol based on the American Society of Echocardiography and European Association of Cardiovascular Imaging recommendations for RV assessment. Key elements: * Left lateral decubitus position when tolerated; semi-recumbent if dyspneic. * ECG-gated digital loops of at least three consecutive cardiac cycles for each view. * Mandatory views: parasternal long-axis and short-axis; apical four-chamber, RV-focused four-chamber, two-chamber, and three-chamber; subcostal four-chamber and IVC. * M-mode through the lateral tricuspid annulus for TAPSE. * Continuous-wave Doppler across the tricuspid valve for peak TR velocity (multiple windows attempted; agitated saline contrast may be used to improve TR signal at operator discretion). * Tissue Doppler at the lateral tricuspid annulus for S

Acute PE confirmed by computed tomography pulmonary angiogram (CTPA) performed within 24 h

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adults, hemodynamically stable with acute pulmonary embolism

You may qualify if:

• Age ≥ 18 years. Acute PE confirmed by computed tomography pulmonary angiogram (CTPA) performed within 24 h of presentation.
• CBC obtained within 24 h of admission and before any blood transfusion. Transthoracic echocardiography feasible within 24 h of admission. Written informed consent.

You may not qualify if:

• Active hematologic malignancy or recent chemotherapy with myelosuppressive intent.
• Red blood cell transfusion within the preceding 90 days.
• Known hemoglobinopathy (e.g., sickle cell disease, thalassemia major).
• Chronic dialysis or eGFR \< 15 mL/min/1.73 m².
• Pre-existing severe pulmonary hypertension (resting mean PAP ≥ 35 mmHg by prior right heart catheterization or echocardiographic PASP ≥ 60 mmHg before this admission), severe left-sided valvular disease, or known severe biventricular dysfunction.
• Hemodynamic instability requiring vasopressors at the time of echocardiography, as their hemodynamics may distort RV-PA coupling estimates.
• Inadequate echocardiographic image quality precluding measurement of TAPSE and a quantifiable TR jet for PASP estimation.
• Inability to provide informed consent.

Sponsors & Collaborators

• Assiut University: lead

MeSH Terms

Conditions

Embolism

Condition Hierarchy (Ancestors)

Embolism and Thrombosis; Vascular Diseases; Cardiovascular Diseases

Central Study Contacts

Entsar Hsanen Mohamed, lecturer

CONTACT

+201019968106; entsar.hsanen@aun.edu.eg

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: lecturer

Study Record Dates

• First Submitted: May 21, 2026
• First Posted: June 1, 2026
• Study Start: June 15, 2026
• Primary Completion (Estimated): June 15, 2027
• Study Completion (Estimated): December 15, 2027
• Last Updated: June 1, 2026

Record last verified: 2026-05