NCT07608289

Brief Summary

Tooth extraction leads to a substantial reduction in alveolar bone volume, with up to 25% loss within the first year and up to 40-60% within three years. This prospective randomized clinical study aims to compare four commonly used methods of alveolar ridge preservation, evaluating their effectiveness in maintaining bone volume for later prosthetic or implant rehabilitation. Alveolar dimensions will be measured using calibrated CBCT imaging pre-extraction and at six months post-extraction.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
80

participants targeted

Target at P50-P75 for not_applicable

Timeline
31mo left

Started Jan 2025

Longer than P75 for not_applicable

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress36%
Jan 2025Dec 2028

Study Start

First participant enrolled

January 1, 2025

Completed
1.3 years until next milestone

First Submitted

Initial submission to the registry

April 30, 2026

Completed
27 days until next milestone

First Posted

Study publicly available on registry

May 27, 2026

Completed
1.6 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 31, 2027

Expected
1 year until next milestone

Study Completion

Last participant's last visit for all outcomes

December 31, 2028

Last Updated

May 27, 2026

Status Verified

May 1, 2026

Enrollment Period

3 years

First QC Date

April 30, 2026

Last Update Submit

May 20, 2026

Conditions

Tooth Extraction Site Healing

Keywords

Socket preservationautogenous dentintooth extractionalveolar ridge augmentation

Outcome Measures

Primary Outcomes (1)

  • Alveolar bone width

    Absolute and relative change in the alveolar bone width at 1 mm, 3 mm, and 5 mm below the alveolar crest measured from CBCT imagery.

    6 months

Study Arms (4)

Spontaneous healing secured with a stitch (control group)

ACTIVE COMPARATOR

Wound after the tooth extraction will be secured with a stitch without addition of any augmentation material.

Procedure: Tooth extraction left to heal spontaneously

Colagen sponge

EXPERIMENTAL

Wound after the tooth extraction will be filled with a collagen sponge (Parasorb Cone, Resorba, Germany) and secured with a stitch.

Procedure: Tooth extraction plus collagen sponge

Tricalcium phosphate xenograft

EXPERIMENTAL

Wound after the tooth extraction will be filled with tricalcium phosphate xenograft (Poresorb TCP, Lasak, Czech Republic), covered with a collagen sponge (Parasorb Cone, Resorba, Germany), and secured with a stitch.

Procedure: Tooth extraction plus tricalcium phosphate

Autogenous dentin

EXPERIMENTAL

Wound after the tooth extraction will be filled with grounded autogenous dentin, covered with a collagen sponge (Parasorb Cone, Resorba, Germany), and secured with a stitch.

Procedure: Tooth extraction plus autogenous dentin

Interventions

Tooth extraction left to heal spontaneouslyPROCEDURE

Wound after the tooth extraction will be secured with a stitch without addition of any augmentation material.

Spontaneous healing secured with a stitch (control group)
Tooth extraction plus collagen spongePROCEDURE

Wound after the tooth extraction will be filled with a collagen sponge (Parasorb Cone, Resorba, Germany) and secured with a stitch.

Colagen sponge
Tooth extraction plus tricalcium phosphatePROCEDURE

Wound after the tooth extraction will be filled with tricalcium phosphate xenograft (Poresorb TCP, Lasak, Czech Republic), covered with a collagen sponge (Parasorb Cone, Resorba, Germany), and secured with a stitch.

Tricalcium phosphate xenograft
Tooth extraction plus autogenous dentinPROCEDURE

Wound after the tooth extraction will be filled with grounded autogenous dentin, covered with a collagen sponge (Parasorb Cone, Resorba, Germany), and secured with a stitch.

Autogenous dentin

Eligibility Criteria

Age18 Years - 70 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • years
  • no active periodontitis
  • signed informed consent with participation in the study
  • need for extraction of teeth other than third molars
  • patients requesting only standard/reimbursed care

You may not qualify if:

  • drug or alcohol abuse
  • ongoing chemotherapy
  • ongoing radiotherapy
  • pregnancy
  • ongoing treatment of osteoporosis or other biological treatment with MRONJ risk
  • low compliance
  • patients asking for premium care

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University Hospital Ostrava

Ostrava, 70852, Czechia

RECRUITING

Related Publications (6)

  • Yuceer-Cetiner E, Ozkan N, Onger ME. Effect of Autogenous Dentin Graft on New Bone Formation. J Craniofac Surg. 2021 Jun 1;32(4):1354-1360. doi: 10.1097/SCS.0000000000007403.

    PMID: 33405453BACKGROUND

  • Lopez Sacristan H, Del Canto Pingarron M, Alobera Gracia MA, de Elio Oliveros J, Diaz Pedrero R, Seco-Calvo J. Use of autologous tooth-derived material as a graft in the post-extraction socket. Split-mouth study with radiological and histological analysis. BMC Oral Health. 2024 Jul 23;24(1):832. doi: 10.1186/s12903-024-04576-0.

    PMID: 39044178BACKGROUND

  • Isola G, Santonocito S, Di Tommasi S, Torrisi S, Iorio-Siciliano V, Caltabiano R, Ramaglia L, Torrisi P. Use of Autogenous Tooth-Derived Mineralized Dentin Matrix in the Alveolar Ridge Preservation Technique: Clinical and Histologic Evaluation. Int J Periodontics Restorative Dent. 2022 Jul-Aug;42(4):497-504. doi: 10.11607/prd.6170.

    PMID: 35830314BACKGROUND

  • Yang F, Ruan Y, Bai X, Li Q, Tang X, Chen J, Chen Y, Wang L. Alveolar ridge preservation in sockets with severe periodontal destruction using autogenous partially demineralized dentin matrix: A randomized controlled clinical trial. Clin Implant Dent Relat Res. 2023 Dec;25(6):1019-1032. doi: 10.1111/cid.13247. Epub 2023 Jul 16.

    PMID: 37455372BACKGROUND

  • Hussain AA, Al-Quisi AF, Abdulkareem AA. Efficacy of Autogenous Dentin Biomaterial on Alveolar Ridge Preservation: A Randomized Controlled Clinical Trial. Biomed Res Int. 2023 Dec 27;2023:7932432. doi: 10.1155/2023/7932432. eCollection 2023.

    PMID: 38179035BACKGROUND

  • Del Canto-Diaz A, de Elio-Oliveros J, Del Canto-Diaz M, Alobera-Gracia MA, Del Canto-Pingarron M, Martinez-Gonzalez JM. Use of autologous tooth-derived graft material in the post-extraction dental socket. Pilot study. Med Oral Patol Oral Cir Bucal. 2019 Jan 1;24(1):e53-e60. doi: 10.4317/medoral.22536.

    PMID: 30573707BACKGROUND

MeSH Terms

Interventions

Tooth Extractiontricalcium phosphate

Intervention Hierarchy (Ancestors)

Oral Surgical ProceduresSurgical Procedures, OperativeDentistry

Study Officials

  • Martin Starosta, Assoc. Prof.

    University of Ostrava

    STUDY CHAIR

Central Study Contacts

Petr Jalůvka, MDDr.

CONTACT

+420 596 623 518petr.jaluvka@osu.cz

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

April 30, 2026

First Posted

May 27, 2026

Study Start

January 1, 2025

Primary Completion (Estimated)

December 31, 2027

Study Completion (Estimated)

December 31, 2028

Last Updated

May 27, 2026

Record last verified: 2026-05

Locations

CZ(1)