Improving Healing in Children After Tooth Extraction Using Laser Therapy or Hyaluronic Acid

NCT07205640 | Not Yet Recruiting

• 1 other identifier: LLLTvsHA-2025
• Study Type: interventional
• Target: 36
• Locations: 1 country
• Sites: 1

Brief Summary

Tooth extraction may be an unpleasant and painful experience for children, Post-extraction wound healing. Low-level laser therapy (LLLT) is a widely used adjuvant treatment for wound healing, resulting in both an increase in cell number and an increase in cell metabolism. HA it is an important component of the extracellular matrix and a constituent of the neural, connective, and epithelial tissues.

Conditions

Mesh; Healthy Volunteer; Low Level Laser Therapy; Hyaluronic Acid Gel for Preservation the Extraction Socket; Extraction Socket Healing; Badly Decayed Molars; Tooth Extraction Site Healing

Keywords

hyaluronic acid; low level laser therapy; tooth extraction

Outcome Measures

Primary Outcomes (1)

• wound size

  Wound size unit of measure : mm (millimeters) (mesiodistal and buccolingual dimension of each socket).

  7 days

Secondary Outcomes (4)

• Tissue Color Changes

  Day 0, Day 3, and Day 7 post-extraction.

• Bleeding Upon Palpation

  Day 0, Day 3, and Day 7 post-extraction.

• Pus Presence

  Day 0, Day 3, and Day 7 post-extraction.

• Pain Level During Application

  Immediately after intervention (Day 0).

Study Arms (2)

Low-Level Laser Therapy (LLLT)

EXPERIMENTAL

Participants in this arm will receive low-level laser therapy (LLLT) immediately after extraction of the first permanent molar.

Device: Low-Level Laser Therapy

Hyaluronic Acid (HA)

EXPERIMENTAL

Participants in this arm will receive hyaluronic acid (HA) immediately after extraction of the first permanent molar.

Drug: Hyaluronic Acid (HA)

Interventions

Low-Level Laser Therapy DEVICE

A 980 nm diode laser will be applied immediately after extraction of the first permanent molar. The laser will be used in continuous mode at 0.5 W, with a total energy of 300 J, applied for 60 seconds at three points around the extraction socket.

Low-Level Laser Therapy (LLLT)

Hyaluronic Acid (HA) DRUG

Hyaluronic acid gel will be applied directly into the extraction socket immediately after tooth removal.

Hyaluronic Acid (HA)

Eligibility Criteria

• Age: 6 Years - 10 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17)

You may qualify if:

• Children aged from six to ten years.
• Children of both genders.
• Children with badly decayed first permanent molar beyond repair and indicated for extraction.
• Parents acceptance to participate in the study.

You may not qualify if:

• Medically compromised children.
• Uncooperative children.
• Children who will not attend the follow up visits

Sponsors & Collaborators

• Cairo University: lead

Study Sites (1)

Faculty Of Oral & Dental Medicine - Cairo University

Giza, EL Menial, 12613, Egypt

Location

Related Links

• Background reference on low-level laser therapy and wound healing in dentistry.

MeSH Terms

Interventions

Low-Level Light Therapy; Hyaluronic Acid

Intervention Hierarchy (Ancestors)

Laser Therapy; Therapeutics; Phototherapy; Glycosaminoglycans; Polysaccharides; Carbohydrates

Study Officials

• Mona Ali Abd Elhafiz, BDS

  Cairo University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Mona Ali Abd Elhafiz, BDS

CONTACT

+201000323801; info@cu.edu.eg

Mona Ali AbdelHafiz, BDS

CONTACT

+201000323801; mona.ali@dentistry.cu.edu.eg

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Masking Details: outcome assessors and statistician
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Bachelor Degree in Oral and Dental Medicine

Study Record Dates

• First Submitted: August 8, 2025
• First Posted: October 3, 2025
• Study Start: December 1, 2025
• Primary Completion: December 1, 2025
• Study Completion (Estimated): December 1, 2026
• Last Updated: October 3, 2025

Record last verified: 2025-09

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)