Autogenous Tooth Bone Graft for Alveolar Socket Preservation

NCT07267637 | Active Not Recruiting DMC

• 1 other identifier: SU-DENT-ATBG-2025-HH
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this clinical experiment is to assess how well autogenous tooth bone grafting preserves the alveolar socket after surgical tooth extraction. Before being inserted into the socket, the graft is made from the patient's own extracted tooth and ground into a particle. Twenty Yemeni patients who needed their teeth extracted are included in the trial, and they will be followed up with clinical and radiographic procedures using cone-beam computed tomography (CBCT) for six months. The primary objective is to ascertain whether the autogenous dental bone graft can preserve the height, width, and density of alveolar bone, offering a secure, affordable, and biocompatible substitute for traditional grafting materials.

Conditions

Alveolar Bone Grafting; Bone Regeneration Following Wisdom Teeth Extraction; Tooth Extraction Site Healing

Keywords

Autogenous Tooth Bone Graft; Socket Preservation; CBCT Imaging; Bone Density Measurement; Bone Regeneration in Dentistry

Outcome Measures

Primary Outcomes (1)

• "Alveolar Bone Height, Width, and Density Preservation with Autogenous Tooth Bone Graft"

  This study aims to evaluate the effectiveness of autogenous tooth bone grafts in preserving alveolar bone following tooth extraction. The study will assess changes in alveolar bone height, width, and density using Cone Beam Computed Tomography (CBCT) at two time points: before extraction (baseline) and 6 months post-grafting. The outcome measures are: Alveolar Bone Height: Measured in millimeters using CBCT at baseline and 6 months. Alveolar Bone Width: Measured in millimeters using CBCT at baseline and 6 months. Alveolar Bone Density: Measured in Hounsfield units using CBCT at both time points. The intervention involves using the patient's own extracted tooth to create a bone graft placed into the socket, promoting healing and bone regeneration. This study will determine the effectiveness of autogenous tooth bone grafts in preventing bone resorption and preserving alveolar socket structure.

  "Before extraction and 6 months post-intervention"

Study Arms (1)

Autogenous Tooth Bone Graft Intervention Group

EXPERIMENTAL

"In this arm of the study, participants will receive an autogenous tooth bone graft for alveolar socket preservation following surgical tooth extraction. The intervention involves the extraction of the patient's own tooth, which will be processed and used as a bone graft. This graft will be placed into the empty socket immediately after the extraction. The purpose of this intervention is to prevent bone resorption, promote natural healing, and support bone regeneration within the extraction site. CBCT scans will be performed before extraction to measure baseline bone dimensions and will be repeated 6 months post-intervention to assess the success of bone preservation in terms of height, width, and density."

Biological: "Autogenous Tooth Bone Graft"

Interventions

"Autogenous Tooth Bone Graft" BIOLOGICAL

"The intervention involves the use of the patient's own extracted tooth to create a bone graft for alveolar socket preservation following surgical tooth extraction. The patient's tooth is carefully processed to remove caries, periodontal ligaments, pulp, and any restorative materials, leaving behind a complete tooth structure (enamel, dentin, and cementum). This tooth is then crushed, disinfected, and treated before being placed into the empty socket. This graft helps maintain the structure of the alveolar bone by promoting natural bone regeneration and preventing resorption. The bone graft will be monitored for its efficacy in preserving alveolar bone height, width, and density, assessed using Cone Beam Computed Tomography (CBCT)."

Autogenous Tooth Bone Graft Intervention Group

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• \- Absence of systemic diseases.
• Very good to accepted oral hygiene.
• Patients with impacted teeth requiring extraction.
• Patients between the ages of 16 and 50.
• No history of smoking.
• No history of any other drug use.
• Patients who were cooperative, motivated, to attend the follow-up and maintenance visits.

You may not qualify if:

• Systemic conditions or pharmacological therapies that could be an absolute contraindication for the intervention (such as un controlled diabetics, immunocompromised states, or treatment with oral or parenteral bisphosphonates).
• Poor oral hygiene.
• Acute exacerbation of chronic infection like pain or swelling.
• Pregnant women, children, elderly (\>60 years), physically and mentally challenged, terminally and seriously ill.
• Hight Smoking tendency.
• Patients who refused to participate in the trial.
• Uncooperative Patients who won't be able to maintain the follow up visits

Sponsors & Collaborators

• Haifaa Mohammed Al-hussini: lead

Study Sites (1)

Sana'a University faculty of Dentisrty

Sanaa, Sanaa Governorate, Yemen

Location

Related Publications (2)

• Valdec S, Pasic P, Soltermann A, Thoma D, Stadlinger B, Rucker M. Alveolar ridge preservation with autologous particulated dentin-a case series. Int J Implant Dent. 2017 Dec;3(1):12. doi: 10.1186/s40729-017-0071-9. Epub 2017 Mar 30.

  PMID: 28361377 RESULT

• Mahardawi B, Damrongsirirat N, Dhanesuan K, Subbalekha K, Mattheos N, Pimkhaokham A. Radiographic changes after alveolar ridge preservation using autogenous raw tooth particles versus xenograft: A prospective controlled clinical trial. Clin Oral Implants Res. 2024 Dec;35(12):1597-1606. doi: 10.1111/clr.14348. Epub 2024 Aug 12.

  PMID: 39132806 RESULT

Related Links

• This study compares the effectiveness of autogenous raw tooth particles versus xenografts in preserving alveolar bone after tooth extraction. It uses radiographic assessments to evaluate bone resorption and preservation over time. The research provides i
• "This study discusses the use of autologous particulated dentin as a bone substitute for alveolar ridge preservation. The method demonstrates the potential of autologous dentin for bone augmentation in implant therapy, providing a viable alternative to x

Study Officials

• Haifaa Alhussini, BDS, MSc

  Sana'a University Faculty of Dentistry

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: "Principal Investigator, Haifaa Al-Hussini, BDS, MSc Candidate, Sana'a University"

Model Details: This is a single-arm, open-label clinical trial designed to evaluate the efficacy of autogenous tooth bone grafts for alveolar socket preservation following sugrical tooth extraction. The intervention involves the use of the patient's own extracted tooth to prepare the bone graft, which will be placed into the extraction socket. The primary objective is to assess changes in alveolar bone height, width, and density before extraction and after six months of intervention using Cone Beam Computed Tomography (CBCT). All participants will undergo the same procedure, and no control group will be included. The study aims to explore the feasibility and outcomes of using autogenous grafts in dental socket preservation procedures

Study Record Dates

• First Submitted: November 23, 2025
• First Posted: December 5, 2025
• Study Start: July 14, 2024
• Primary Completion: November 1, 2025
• Study Completion (Estimated): August 31, 2026
• Last Updated: December 5, 2025

Record last verified: 2025-12

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP, ICF
• Time Frame: "IPD and supporting information will be made available starting 12 months after the completion of the study. The data will be accessible for a period of 5 years."
• Access Criteria: "Access to IPD and supporting information will be granted to qualified researchers who submit a data request via the ClinicalTrials.gov platform. Researchers must meet the criteria outlined in the Data Use Agreement, which ensures that the data will be used responsibly and for research purposes only."

Locations

YE (1)