Statewide Unified Network for Remote Intervention of Strength and Exercise
SUNRISE
1 other identifier
interventional
120
0 countries
N/A
Brief Summary
This study will evaluate whether a remotely delivered exercise program can improve chemotherapy tolerability in patients with gastrointestinal or lung cancer receiving chemotherapy. In this decentralized, digital randomized clinical trial, up to 120 adults with gastrointestinal or lung cancer will be randomized to either a home-based aerobic and resistance exercise program or home-based progressive stretching program. All study activities will be conducted remotely using digital technologies and home-based assessments. Participants in both groups will receive Bluetooth-enabled wearable devices for monitoring physical activity, body weight, blood pressure, and other health measures. The primary objective is to determine whether exercise improves chemotherapy relative dose intensity compared with stretching. The intervention will continue throughout chemotherapy treatment or for up to 32 weeks.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for not_applicable
Started Jul 2026
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
May 13, 2026
CompletedFirst Posted
Study publicly available on registry
May 19, 2026
CompletedStudy Start
First participant enrolled
July 1, 2026
ExpectedPrimary Completion
Last participant's last visit for primary outcome
August 31, 2027
Study Completion
Last participant's last visit for all outcomes
December 31, 2027
May 19, 2026
May 1, 2026
1.2 years
May 13, 2026
May 13, 2026
Conditions
Outcome Measures
Primary Outcomes (1)
Chemotherapy Relative Dose Intensity
The ratio of the delivered dose intensity to the standard or planned dose intensity.
Up to 32 weeks
Study Arms (2)
Exercise
EXPERIMENTALThe exercise group will engage in aerobic and muscle-strengthening activities.
Stretching
ACTIVE COMPARATORThe stretching group will engage in whole-body static stretching activities.
Interventions
The exercise group will be provided with Bluetooth-enabled devices and home exercise equipment. Participants will meet with an exercise trainer weekly to learn how to engage in the exercise program.
The stretching group will be provided with Bluetooth-enabled devices. Participants will meet with an exercise trainer weekly to learn how to engage in the stretching program.
Eligibility Criteria
You may qualify if:
- Gastrointestinal cancer (esophageal, gastric, pancreatic, colon, and rectal) treated with chemotherapy (and other treatments, as clinically indicated) before surgery OR Lung cancer (non-small cell and small-cell) treated with chemotherapy (and other treatments, as clinically indicated) for advanced- or extensive-stage disease.
- Completion of the modified version of the Physical Activity Readiness Questionnaire.
You may not qualify if:
- Actively treated for another non-gastrointestinal or non-lung malignancy (surveillance with observation is allowed).
- Engage in more than 150 minutes per week of aerobic physical activity and two or more sessions of muscle strengthening activity per week over the last three months (self-report).
- Unable to walk for 6 minutes or two city blocks independently (self-report).
- Enrollment in another study that intervenes upon physical activity, diet, or body composition as a primary objective (self-report).
- Unable to read and speak English.
- No access to a reliable internet connection.
- Currently an AdventHealth employee.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Justin Brown, Ph.D.
AdventHealth
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- INVESTIGATOR, OUTCOMES ASSESSOR
- Purpose
- SUPPORTIVE CARE
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Director, Exercise & Cancer Biology Research Program
Study Record Dates
First Submitted
May 13, 2026
First Posted
May 19, 2026
Study Start (Estimated)
July 1, 2026
Primary Completion (Estimated)
August 31, 2027
Study Completion (Estimated)
December 31, 2027
Last Updated
May 19, 2026
Record last verified: 2026-05
Data Sharing
- IPD Sharing
- Will share