Healthy Aging Through Optimized Exercise

NCT07093216 | Not Yet Recruiting

• 1 other identifier: 300013021
• Study Type: interventional
• Target: 304
• Locations: 0 countries
• Sites: N/A

Brief Summary

here is enormous variation in how individuals respond to exercise and understanding the factors that drive this variation will guide individualized exercise prescriptions to improve or maintain health into older age. This study will help to elucidate reasons for the variation in the responses to exercise in older adults.

Conditions

Aging

Keywords

Intrinsic Capacity; Exercise

Outcome Measures

Primary Outcomes (1)

• Intrinsic Capacity

  Single composite score of results of multiple tests across five domains: 1) Locomotion, 2) Vitality, 3) Sensory, 4) Psychological, and 5) Cognition

  6 months

Study Arms (5)

Dose

EXPERIMENTAL

Testing Dose of Exercise

Behavioral: Exercise

Intensity

EXPERIMENTAL

Testing Intensity of Effort

Behavioral: Exercise

Mode

EXPERIMENTAL

Resistance vs Aerobic

Behavioral: Exercise

Volume

EXPERIMENTAL

Amount of Exercise Performed

Behavioral: Exercise

Time of Day

EXPERIMENTAL

Time of Day Exercise Performed

Behavioral: Exercise

Interventions

Exercise BEHAVIORAL

6 month exercise intervention

Dose; Intensity; Mode; Time of Day; Volume

Eligibility Criteria

• Age: 60 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Written informed consent prior to any study procedure
• + years of age
• \<120 min/wk of self-reported moderate physical activity as assessed by Community Health Activities Model Program for Seniors (CHAMPS) physical activity questionnaire13
• Evidence of impairment in one or more Intrinsic Capacity domains (see section 3.2)
• Passage of a physical exam and diagnostic, graded exercise test with 12-lead ECG reviewed by a cardiologist or otherwise credentialed clinician.

You may not qualify if:

• End-stage disease and/or a life expectancy less than one year
• Resistant hypertension, defined as BP \> 140/90, despite the use of three or more anti-hypertensive drugs
• Chronic kidney disease
• Serum creatinine \>2.5 mg/dL in men or \>2.0 mg/dL in women
• Serum potassium \>5.0 mEq/L
• Urinary protein \> 1 on dipstick
• Abnormal liver enzymes (AST, ALT, or alkaline phosphatase \> 2.5 times the upper limit of normal)
• Severe cardiac disease, including NYHA Class III or IV congestive heart failure, clinically significant aortic stenosis, history of cardiac arrest, use of a cardiac defibrillator, or uncontrolled angina
• Acute myocardial infarction identified by ECG
• Current treatment for malignancy
• Known diagnosis of dementia
• Any other disease or condition that would preclude completion of all testing and exercise training
• Any other condition that would interfere with testing or increase risk of complications during exercise

Sponsors & Collaborators

• University of Alabama at Birmingham: lead

MeSH Terms

Conditions

Motor Activity

Interventions

Exercise

Condition Hierarchy (Ancestors)

Behavior

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Central Study Contacts

Karen Fulton

CONTACT

205.996.4086; fulton31@uab.edu

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: BASIC SCIENCE
• Intervention Model: FACTORIAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: July 14, 2025
• First Posted: July 30, 2025
• Study Start: May 1, 2026
• Primary Completion (Estimated): April 30, 2031
• Study Completion (Estimated): April 30, 2031
• Last Updated: July 30, 2025

Record last verified: 2025-07