The Effect of Preoperative Mirabegron Use on Ureteral Access Sheath Insertion

NCT07566416 | Completed

• 1 other identifier: UASPULS2026
• Study Type: observational
• Target: 125
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study is to evaluate whether there is a difference in the passage rate of the ureteral access sheath between patients who used mirabegron (a beta-3 receptor agonist) for overactive bladder and those who underwent retrograde intrarenal surgery for kidney stones, and those who did not use mirabegron. Considering that beta-3 receptors in the smooth muscle of the ureter cause relaxation in the ureter, the hypothesis that the passage rate of the access sheath increases in those using mirabegron, thus facilitating access to kidney stones and improving surgical success, will be investigated.

Conditions

Kidney Stone; Retrograde Intrarenal Surgery (RIRS); Ureteral Access Sheath

Keywords

kidney stone; mirabegron; ureteral access sheath; retrograde intrarenal surgery

Outcome Measures

Primary Outcomes (1)

• Ureteral access sheath insertion rate

  From January 2022 to December 2024

Secondary Outcomes (1)

• Ureteral injury rate

  From January 2022 to December 2024

Study Arms (2)

Mirabegron Group

Patients using mirabegron for overactive bladder and scheduled for retrograde intrarenal surgery due to kidney stones.

Procedure: Retrograde intrarenal surgery

Control Group

Not using mirabegron and scheduled retrograde intrarenal surgery due to kidney stones.

Procedure: Retrograde intrarenal surgery

Interventions

Retrograde intrarenal surgery PROCEDURE

In our study, we evaluated the üreteral access sheath insertion rate in patients already using mirabegron for overactive bladder and scheduled for RIRS surgery for kidney stones. No additional intervention was performed beyond the routine surgical procedure.

Control Group; Mirabegron Group

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

patients scheduled for RIRS due to kidney stones

You may qualify if:

• patients scheduled for RIRS due to kidney stones

You may not qualify if:

• preoperative ureteral stenting,
• ureteral strictures, history of ureteral or bladder surgery,
• anatomical abnormalities of the urinary tract,
• active urinary tract infection,
• pregnancy,
• uncontrolled hypertension (systolic blood pressure ≥180 mmHg, diastolic blood pressure ≥110 mmHg),
• use of medications affecting ureteral smooth muscle tone

Sponsors & Collaborators

• Ankara Training and Research Hospital: lead

Study Sites (1)

Ankara Training and Research Hospital

Ankara, Altındağ, Turkey (Türkiye)

Location

Related Publications (2)

• Akinci A, Sanci A, Babayigit M, Gogus C. Does preoperative alpha-blocker use affect the results of flexible ureterorenoscopy? Actas Urol Esp (Engl Ed). 2025 Nov;49(9):501836. doi: 10.1016/j.acuroe.2025.501836. Epub 2025 Sep 10. English, Spanish.

  PMID: 40939838 RESULT

• Ermis O, Sabuncu K, Kactan C, Karakus B, Surmeli B, Boz MY, Horuz R. Mirabegron administration for the prevention of ureteral injuries during ureteral access sheath insertion. World J Urol. 2026 Jan 27;44(1):130. doi: 10.1007/s00345-026-06225-3.

  PMID: 41591575 RESULT

MeSH Terms

Conditions

Kidney Calculi

Condition Hierarchy (Ancestors)

Nephrolithiasis; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Urolithiasis; Urinary Calculi; Male Urogenital Diseases; Calculi; Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: UROLOGIST

Study Record Dates

• First Submitted: April 28, 2026
• First Posted: May 5, 2026
• Study Start: January 1, 2022
• Primary Completion: December 12, 2024
• Study Completion: February 10, 2025
• Last Updated: May 5, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)