Evaluation of Retrograde Intrarenal Surgery Results and Stone-free Rate in Children With Kidney Stones

NCT06138704 | Completed

• 1 other identifier: E2-23-5305
• Study Type: observational
• Target: 105
• Locations: 1 country
• Sites: 1

Brief Summary

There is a global increase in the prevalence of urolithiasis in children attributed to lifestyle changes, dietary habits, climate changes, childhood obesity, and the wider availability of ultrasonography. The rising incidence of the disease with its recurrent nature emphasizes the need for minimally invasive therapeutic options. Patients in whom RIRS has been performed in the last four years with increasing experience will be presented, and complications, stone-free rates, and technical details will be discussed. This retrospective Cohort study included children who underwent RIRS. Medical history, serum electrolytes, midstream urine culture, urinalysis, serum creatinine, complete blood count, and coagulation assessments were performed preoperatively. Ultrasonography (USG) was performed three months, 6 months, and 1 year after the procedures to evaluate stone recurrence and hydronephrosis. The investigators analyzed the stone-free rate ,complications, and the conversion to open procedure

Conditions

Renal Stone; Retrograde Intrarenal Surgery

Keywords

Kidney Stone; Retrograde Intrarenal Surgery; Children; Stone Free Rate

Outcome Measures

Primary Outcomes (1)

• Determination of stone-free rate in children who underwent lithotripsy with retrograde intrarenal surgery for kidney stones.

  After the RIRS, patients were monitored with USG in the first month, 3-6-12 months, and stone-free rates were determined.

  USG evaluation was performed postoperative 1. month, 3-6-12-18 months, and kidney stones of the patients were evaluated.

Secondary Outcomes (3)

• How long does it take for renal stones to be cleared after RIRS?

  USG evaluation was performed postoperative 1. month, 3-6-12-18 months, and kidney stones of the patients were evaluated.

• Determination of factors affecting stone-free rate in pediatric patients who underwent RIRS due to kidney stones.

  USG evaluation was performed postoperative 1. month, 3-6-12-18 months, and kidney stones of the patients were evaluated.

• Determining the need for repeated interventions to ensure stone-free status

  Evaluating 4-year hospital records of patients

Other Outcomes (1)

• Determination of procedure-related complications in pediatric patients who underwent RIRS due to kidney stones.

  Evaluating 4-year hospital records of patients

Interventions

Retrograde Intrarenal Surgery PROCEDURE

All RIRS procedures were performed under general anesthesia with direct videoscopic and fluoroscopic guidance. The decision to use a flexible or semirigid ureteroscope depended on the location of the Stones. If this was not enough to pass the ureteroscope, we placed a JJ catheter for passive dilatation. Stones were fragmented using a holmium-YAG laser and grasped by a stone basket when applicable. Contrast injection was performed at the end of the procedures to confirm the absence of extravasation and stone-free status. Ultrasonography (USG) was performed three months, six months, and one year after the procedures to evaluate stone recurrence and hydronephrosis.

Also known as: Lithohtrapsy

Eligibility Criteria

• Age: 3 Months - 18 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

One hundred and five patients (49 boys and 56 girls) with a median age of 6,66+5,27 years (0,25-17,6 years) were treated with RIRS between January 2019 and December 2022. The RIRS procedure could not be performed in 15 cases, whereas it could be performed in 90 cases.

Sponsors & Collaborators

• Ankara City Hospital Bilkent: lead

Study Sites (1)

Ankara Bilkent City Hospital

Ankara, Turkey (Türkiye)

Location

Related Publications (4)

• Clayton DB, Pope JC. The increasing pediatric stone disease problem. Ther Adv Urol. 2011 Feb;3(1):3-12. doi: 10.1177/1756287211400491.

  PMID: 21789094 BACKGROUND

• Copelovitch L. Urolithiasis in children: medical approach. Pediatr Clin North Am. 2012 Aug;59(4):881-96. doi: 10.1016/j.pcl.2012.05.009. Epub 2012 Jun 15.

  PMID: 22857835 BACKGROUND

• Azili MN, Ozcan F, Tiryaki T. Retrograde intrarenal surgery for the treatment of renal stones in children: factors influencing stone clearance and complications. J Pediatr Surg. 2014 Jul;49(7):1161-5. doi: 10.1016/j.jpedsurg.2013.12.023. Epub 2014 Jan 13.

  PMID: 24952809 BACKGROUND

• Karagoz MA, Erihan IB, Doluoglu OG, Ugurlu C, Bagcioglu M, Uslu M, Sarica K. Efficacy and safety of fURS in stones larger than 20 mm: is it still the threshold? Cent European J Urol. 2020;73(1):49-54. doi: 10.5173/ceju.2020.0056. Epub 2020 Jan 3.

  PMID: 32395324 RESULT

MeSH Terms

Conditions

Nephrolithiasis; Kidney Calculi

Condition Hierarchy (Ancestors)

Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Urolithiasis; Male Urogenital Diseases; Urinary Calculi; Calculi; Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms

Study Officials

• Huseyin T Tiryaki, MD

  University of Health Science Ankara Bilkent City Hospital

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Target Duration: 2 Years
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 14, 2023
• First Posted: November 18, 2023
• Study Start: January 1, 2019
• Primary Completion: December 31, 2022
• Study Completion: October 31, 2023
• Last Updated: December 11, 2023

Record last verified: 2023-12

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)