Peak Airway Pressure and Respiratory Mechanics During PRVC Ventilation in Laparoscopic Surgery

NCT07543939 | Not Yet Recruiting

• 1 other identifier: IRB-002-2026
• Study Type: observational
• Target: 52
• Locations: 0 countries
• Sites: N/A

Brief Summary

This study aims to evaluate peak airway pressure and respiratory mechanics during pressure-regulated volume control (PRVC) ventilation in patients undergoing elective laparoscopic abdominal surgery. Pneumoperitoneum and patient positioning during laparoscopic procedures can significantly affect respiratory mechanics, including airway pressures and lung compliance. The study will assess changes in peak airway pressure, dynamic compliance, and other ventilatory parameters during different intraoperative phases. The findings are expected to provide insights into optimizing ventilatory strategies to improve patient safety and minimize ventilator-associated complications during laparoscopic surgery.

Conditions

Intraoperative Ventilation; Respiratory Mechanics

Keywords

PRVC ventilation; Laparoscopic surgery; Peak airway pressure; Dynamic compliance; General anesthesia; Mechanical ventilation

Outcome Measures

Primary Outcomes (1)

• Peak Airway Pressure

  Peak airway pressure (PIP) measured intraoperatively using the anesthesia workstation under standardized pressure-regulated volume control ventilation settings.

  At 0, 5, and 10 minutes intraoperatively

Secondary Outcomes (8)

• Dynamic Compliance

  At 0, 5, and 10 minutes intraoperatively

• Plateau Pressure

  At 0, 5, and 10 minutes intraoperatively

• End-tidal Carbon Dioxide

  At 0, 5, and 10 minutes intraoperatively

• Mean Airway Pressure

  At 0, 5, and 10 minutes intraoperatively

• Oxygen Saturation

  At 0, 5, and 10 minutes intraoperatively

Study Arms (1)

Single Cohort

Adult patients undergoing elective laparoscopic abdominal surgery under general anesthesia with pressure-regulated volume control (PRVC) ventilation. Respiratory parameters are recorded at predefined intraoperative time points.

Other: PRVC Ventilation

Interventions

PRVC Ventilation OTHER

Mechanical ventilation using pressure-regulated volume control mode applied as part of routine intraoperative anesthesia care. No experimental intervention is introduced.

Single Cohort

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult patients undergoing elective laparoscopic abdominal surgery under general anesthesia at a tertiary care center.

You may qualify if:

• Adult patients aged 18-65 years
• Scheduled for elective laparoscopic abdominal surgery under general anesthesia
• ASA physical status I-II
• Patients requiring mechanical ventilation using PRVC mode
• Provided informed consent

You may not qualify if:

• Patients with significant cardiopulmonary disease
• Chronic obstructive pulmonary disease or restrictive lung disease
• Morbid obesity (BMI \> 35 kg/m²)
• Pregnancy
• Emergency surgeries
• Patients with anticipated difficult airway
• Refusal to participate

Sponsors & Collaborators

• Specialized Medical Center (SMC): lead

Study Officials

• Salaheldin A Abdelaziz Ahmed, MD

  Specialized Medical Center (SMC), Riyadh, Saudi Arabia

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Salaheldin A Abdelaziz Ahmed, MD

CONTACT

+201001308006; saladin28.sa@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 13, 2026
• First Posted: April 22, 2026
• Study Start: May 1, 2026
• Primary Completion (Estimated): September 1, 2026
• Study Completion (Estimated): October 1, 2026
• Last Updated: April 22, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will not share