Effects of Low-Flow Sevoflurane Anesthesia on Pulmonary Function During One-Lung Ventilation

NCT07085546 | Completed

• 1 other identifier: 2025-05/56
• Study Type: observational
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

This prospective observational study aims to evaluate the effects of low-flow sevoflurane anesthesia on respiratory mechanics, gas exchange, and postoperative pulmonary function in patients undergoing one-lung ventilation (OLV) during thoracic surgery. The study will compare patients receiving low-flow sevoflurane anesthesia with those receiving standard-flow anesthesia, focusing on parameters such as lung compliance, arterial oxygen levels (PaO₂), and postoperative oxygen requirements. Fifty patients scheduled for elective thoracic surgery with OLV will be included. Data will be collected intraoperatively and postoperatively, and standard anesthesia protocols will be followed according to the attending anesthesiologist's preference. The results are expected to provide new insights into the safety and efficacy of low-flow anesthesia protocols in thoracic surgery, potentially guiding future clinical practice to reduce postoperative pulmonary complications.

Conditions

One-lung Ventilation (OLV); Low-flow Anesthesia; Thoracic Surgery; Respiratory Mechanics; Sevoflurane

Outcome Measures

Primary Outcomes (3)

• Postoperative Oxygen Requirement

  24-hour postoperative period

• Static Lung Compliance

  Static lung compliance (Cstat) will be calculated using the formula: Cstat = VT / (Pplateau - PEEP), where VT is tidal volume, Pplateau is plateau pressure, and PEEP is positive end-expiratory pressure

  Intraoperative period

• Arterial Oxygen Pressure (PaO₂)

  Arterial oxygen pressure (PaO₂) will be measured from arterial blood gas analysis during one-lung ventilation

  Intraoperative period

Study Arms (2)

Low-Flow Sevoflurane Group

Patients receiving low-flow sevoflurane anesthesia during one-lung ventilation

Standard-Flow Sevoflurane Group

Patients receiving standard-flow sevoflurane anesthesia during one-lung ventilation

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Adult patients aged 18 to 75 years who are scheduled for elective video-assisted thoracoscopic surgery (VATS) or thoracotomy under general anesthesia with one-lung ventilation at Dr. Abdurrahman Yurtaslan Oncology Training and Research Hospital. Eligible participants will have ASA physical status I-III and no acute respiratory failure.

You may qualify if:

• Age between 18 and 75 years American Society of Anesthesiologists (ASA) physical status I-III Scheduled for elective video-assisted thoracoscopic surgery (VATS) or thoracotomy No acute respiratory failure

You may not qualify if:

• Severe chronic obstructive pulmonary disease (COPD) or restrictive lung disease Body mass index (BMI) greater than 40 kg/m² Cardiac dysfunction with ejection fraction (EF) less than 40% Requirement for emergency thoracic surgery

Sponsors & Collaborators

• Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital: lead

Study Sites (1)

Dr. Abdurrahman Yurtaslan Oncology Training and Research Hospital

Ankara, Turkey (Türkiye)

Location

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Dr. - Department of Anesthesiology and Reanimation

Study Record Dates

• First Submitted: July 12, 2025
• First Posted: July 25, 2025
• Study Start: July 15, 2025
• Primary Completion: September 15, 2025
• Study Completion: October 1, 2025
• Last Updated: October 2, 2025

Record last verified: 2025-09

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)