Effects of Sevoflurane Versus Desflurane Anesthesia Under Protective Mechanical Ventilation for Robotic Assisted Surgery
1 other identifier
interventional
50
1 country
1
Brief Summary
Inhalational anesthetics, when used in abdominal surgery, offer advantages of lung protection and reduced alveolar inflammation. There is little literature, however, in the comparative use of sevoflurane versus desflurane anesthesia in patients undergoing abdominal robotic-assisted surgery and their effects on lung mechanics.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable
Started May 2025
Shorter than P25 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
May 1, 2025
CompletedFirst Submitted
Initial submission to the registry
September 29, 2025
CompletedFirst Posted
Study publicly available on registry
December 26, 2025
CompletedPrimary Completion
Last participant's last visit for primary outcome
January 30, 2026
CompletedStudy Completion
Last participant's last visit for all outcomes
February 28, 2026
CompletedDecember 26, 2025
October 1, 2025
9 months
September 29, 2025
December 12, 2025
Conditions
Outcome Measures
Primary Outcomes (1)
airway plateau pressure
Airway plateau pressure (cmH2O) as displayed on the anesthesia ventilator at the specified time points will be recorded for each participant.
Perioperatively
Study Arms (2)
Sevoflurane (Volatile Anesthetic)
ACTIVE COMPARATORDeslfurane (Volatile Anesthetic)
ACTIVE COMPARATORInterventions
Sevoflurane for robotic assisted laparoscopic surgery
Desflurane for robotic assisted laparoscopic surgery
Eligibility Criteria
You may qualify if:
- Age 18 to 87 years
- Undergoing elective robotic-assisted abdominal surgery
- ASA physical status I-III
You may not qualify if:
- ASA IV or V
- Emergency surgery
- Renal insufficiency
- Clinically significant respiratory disease
- Cardiomyopathy
- Uncontrolled hypertension
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Aretaieion University Hospital
Athens, 11528, Greece
Related Publications (1)
Herling SF, Dreijer B, Wrist Lam G, Thomsen T, Moller AM. Total intravenous anaesthesia versus inhalational anaesthesia for adults undergoing transabdominal robotic assisted laparoscopic surgery. Cochrane Database Syst Rev. 2017 Apr 4;4(4):CD011387. doi: 10.1002/14651858.CD011387.pub2.
PMID: 28374886RESULT
MeSH Terms
Interventions
Intervention Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
Aikaterini Melemeni, Professor
Aretaieion University Hospital, National And Kapodistrian University Of Athens
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- TRIPLE
- Who Masked
- PARTICIPANT, CARE PROVIDER, INVESTIGATOR
- Purpose
- PREVENTION
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Assistant Professor of Anesthesiology
Study Record Dates
First Submitted
September 29, 2025
First Posted
December 26, 2025
Study Start
May 1, 2025
Primary Completion
January 30, 2026
Study Completion
February 28, 2026
Last Updated
December 26, 2025
Record last verified: 2025-10
Data Sharing
- IPD Sharing
- Will not share