Comparison of FCV and VCV in One-Lung Ventilation

NCT07392086 | Recruiting

• 1 other identifier: 2025-11/1250
• Study Type: observational
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

One-lung ventilation (OLV) is commonly used during thoracic surgery but may negatively affect lung mechanics and gas exchange. Different ventilation strategies are used during OLV, and their effects on respiratory parameters remain an important clinical concern. Flow-controlled ventilation (FCV) is a newer ventilation mode that allows precise control of inspiratory and expiratory flow, potentially improving lung mechanics and gas exchange. Volume-controlled ventilation (VCV) is a widely used conventional ventilation strategy during thoracic anesthesia. The FCVOLVent study is a multicenter, prospective observational study designed to compare the effects of FCV and VCV during one-lung ventilation in adult patients undergoing thoracic surgery. Patients will be ventilated with either FCV or VCV as part of routine clinical practice. The study aims to evaluate respiratory mechanics and oxygenation parameters, including the PaO₂/FiO₂ ratio, airway pressures, lung compliance, and mechanical power during surgery. Data will be collected at predefined time points during one-lung ventilation. The results of this study are expected to provide real-world clinical evidence on the potential advantages and limitations of flow-controlled ventilation compared with volume-controlled ventilation during one-lung ventilation.

Conditions

One-lung Ventilation (OLV); Thoracic Surgery; Respiratory Mechanics

Keywords

Flow-Controlled Ventilation; Thoracic Anesthesia; Volume-Controlled Ventilation; One-Lung Ventilation

Outcome Measures

Primary Outcomes (1)

• Oxygenation Capacity

  PaO₂/FiO₂ Ratio

  Intraoperative period (during one-lung ventilation)

Secondary Outcomes (1)

• Respiratory parameters

  Intraoperative period (during one-lung ventilation)

Study Arms (2)

All participants

One-Lung Ventilation with Volume-Controlled Ventilation (VCV)

Prospective observational cohort study

Flow-Controlled Ventilation during One-Lung Ventilation

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Adult patients aged 18 years and older undergoing thoracic surgery requiring one-lung ventilation with flow-controlled ventilation (FCV) or volume-controlled ventilation (VCV).

Sponsors & Collaborators

• Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital: lead
• Kocaeli City Hospital: collaborator
• Yedikule Training and Research Hospital: collaborator
• Sakarya University: collaborator
• Ataturk University: collaborator

Study Sites (1)

Health Sciences University Dr. Abdurrahman Yurtarslan Ankara Oncology Training and Research Hospital

Ankara, Yenimahalle, 06200, Turkey (Türkiye)

RECRUITING

Related Publications (1)

• Bialka S, Palaczynski P, Szuldrzynski K, Wichary P, Kowalski D, van der Hoorn JWA, Bottinger L, Misiolek H. Flow-controlled ventilation - a new and promising method of ventilation presented with a review of the literature. Anaesthesiol Intensive Ther. 2022;54(1):62-70. doi: 10.5114/ait.2022.112889.

  PMID: 35142160 RESULT

Study Officials

• Hakan Miniksar

  Health Sciences University Dr. Abdurrahman Yurtarslan Ankara Oncology Training and Research Hospital

  STUDY CHAIR

Central Study Contacts

Ökkeş Hakan Miniksar, Assoc.Prof

CONTACT

+905304686718; hminiksar@yahoo.com

Seher Altınel, Assoc.Prof

CONTACT

altinelseher@yahoo.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 1 Year
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor of Anesthesiology and Reanimation, Principal Investigator

Study Record Dates

• First Submitted: January 22, 2026
• First Posted: February 6, 2026
• Study Start: January 1, 2026
• Primary Completion: July 30, 2026
• Study Completion (Estimated): December 1, 2026
• Last Updated: February 6, 2026

Record last verified: 2026-01

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)