The Effects of Dexamethasone and Ibuprofen on Postoperative Analgesia in Patients Undergoing Hand and Forearm Surgery With Axillary Brachial Plexus Block

NCT07531407 | Completed FDA Drug

• 1 other identifier: SBU-ANES-BCC-01
• Study Type: observational
• Target: 79
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to comparatively examine the effects of preemptive intravenous dexamethasone and intravenous ibuprofen use on the duration of analgesia in ultrasound-guided Axillary Brachial Plexus Block applications for patients undergoing hand and forearm surgery. Furthermore, investigating the relationship between the study drugs and the incidence of Postoperative Nausea and Vomiting and determining the time until the first use of rescue analgesic are also among the secondary objectives.

Conditions

Dexamethasone; Ibuprofen; Hand Surgery; Forearm Surgery; Postoperative Analgesia; Axillary Block

Keywords

Axillary Brachial Plexus Blockade; Hand and Forearm Surgery; Postoperative Analgesia; Intravenous Dexamethasone; Intravenous Ibuprofen

Outcome Measures

Primary Outcomes (1)

• Duration of analgesia

  Duration of analgesia was defined as the time from the performance of the block until the patient's first report of pain.

  24 hours

Secondary Outcomes (1)

• Incidence of PONV

  24 hours

Study Arms (2)

D

Patients who had intravenouse dexamethasone

Drug: IV Dexamethasone 8mg

I

Patients who had intravenouse ibuprofen

Drug: iv ibuprofen

Interventions

IV Dexamethasone 8mg DRUG

Patients who are in group D had intravenouse 8 mg dexamethasone before axillary brachial plexus blockade.

D

iv ibuprofen DRUG

Patients who are in group I had intravenouse 400 mg ibuprofen before axillary brachial plexus blockade.

I

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients aged between 18 and 65 years, with ASA physical status I or II, who were scheduled for hand or forearm surgery, were included in the study.

You may qualify if:

• Patient's consent to participate in the study (Informed consent)
• Aged between 18 and 65 years
• ASA physical status I or II
• Being oriented and cooperative
• Scheduled to undergo hand or forearm surgery
• Body Mass Index (BMI) below 40 kg/m²
• Scheduled for axillary brachial plexus blockade

You may not qualify if:

• Patient's refusal to participate in the study
• Refusal of regional anesthesia
• Known allergy to local anesthetics
• Known allergy to ibuprofen
• Known allergy to dexamethasone
• Presence of coagulopathy
• Local infection at the site of regional anesthesia application
• Presence of malignancy at the surgical site
• Diagnosis of diabetes mellitus
• Body Mass Index (BMI) of 40 kg/m² or above
• Duration of surgery exceeding 4 hours
• Administration of opioid medication during the preoperative or intraoperative period

Sponsors & Collaborators

• Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization: lead

Study Sites (1)

Prof. Dr. Cemil Tascioglu City Hospital

Istanbul, 34384, Turkey (Türkiye)

Location

MeSH Terms

Interventions

Dexamethasone; Ibuprofen

Intervention Hierarchy (Ancestors)

Pregnadienetriols; Pregnadienes; Pregnanes; Steroids; Fused-Ring Compounds; Polycyclic Compounds; Steroids, Fluorinated; Phenylpropionates; Acids, Carbocyclic; Carboxylic Acids; Organic Chemicals

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 1 Day
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: April 9, 2026
• First Posted: April 15, 2026
• Study Start: May 1, 2025
• Primary Completion: October 31, 2025
• Study Completion: October 31, 2025
• Last Updated: May 22, 2026

Record last verified: 2026-05

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)