Preemptive Analgesia in Laparoscopic Hysterectomy

NCT07401927 | Not Yet Recruiting

• 1 other identifier: GOKAEK 2025/13/9
• Study Type: observational
• Target: 70
• Locations: 0 countries
• Sites: N/A

Brief Summary

The aim of this study is to evaluate the effects of ibuprofen and paracetamol administered for pre-emptive analgesia to patients undergoing laparoscopic hysterectomy on pain scores during the first 24 hours postoperatively, the amount of opioids consumed postoperatively, and adverse effects such as postoperative nausea and vomiting.

Conditions

Postoperative Analgesia; Laparoscopic Hysterectomy

Outcome Measures

Primary Outcomes (1)

• Postoperative analgesia

  Postoperative analgesia was assessed by measuring postoperative pain intensity using the Visual Analog Scale (VAS) and by recording cumulative opioid or rescue analgesic consumption. The Visual Analog Scale ranges from 0 to 10, where 0 indicates no pain and 10 indicates the worst imaginable pain. Lower pain scores and reduced analgesic requirements were considered indicators of better postoperative analgesia.

  from the end of surgery up to 24 hours postopeartively

Secondary Outcomes (2)

• İntraoperative analgesia

  During surgery (from skin incision until the end of surgery)

• Intraoperative hemodynamic instability

  During surgery (from induction of anesthesia until the end of surgery)

Study Arms (2)

Group İ (İbuprofen)

Patients who are administered ibuprofen pre-emptively analgesia, in accordance with routine clinical practice.

Drug: Ibuprofen

Group P (Parasetamol)

Patients who are administered parasetamol pre-emptively analgesia, in accordance with routine clinical practice.

Drug: Parasetamol

Interventions

Ibuprofen DRUG

Administered as part of standard institutional anesthesia practice.

Also known as: ibuprofen 400 mg

Group İ (İbuprofen)

Parasetamol DRUG

Administered as part of standard institutional anesthesia practice.

Also known as: parasetamol 1 g

Group P (Parasetamol)

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Female patients aged 18 to 70 who are scheduled to undergo laparoscopic hysterectomy surgery.

You may qualify if:

• Aged 18-70
• ASA I-III patients
• Patients undergoing elective laparoscopic hysterectomy surgery

You may not qualify if:

• Emergency surgery
• Patients who require conversion to abdominal hysterectomy during the intraoperative period
• Those with severe liver or kidney failure, a history of long-term nonsteroidal anti-inflammatory and opioid analgesic use
• Those with a history of gastrointestinal bleeding, peptic ulcer or inflammatory bowel disease, diabetes or other neuropathic diseases
• Patients unable to use patient-controlled analgesia (PCA) devices

Sponsors & Collaborators

• Giresun University: lead

MeSH Terms

Interventions

Ibuprofen

Intervention Hierarchy (Ancestors)

Phenylpropionates; Acids, Carbocyclic; Carboxylic Acids; Organic Chemicals

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Anesthesiology and Reanimation physician

Study Record Dates

• First Submitted: January 27, 2026
• First Posted: February 11, 2026
• Study Start: February 2, 2026
• Primary Completion: April 1, 2026
• Study Completion: May 1, 2026
• Last Updated: February 11, 2026

Record last verified: 2026-02

Data Sharing

• IPD Sharing: Will not share