Distinct Directional Postural Stability Deficits Across Lower Limb Musculoskeletal Disorders

NCT07508163 | Not Yet Recruiting

• 1 other identifier: Approved
• Study Type: observational
• Target: 90
• Locations: 0 countries
• Sites: N/A

Brief Summary

Lateral ankle sprain (LAS) and patellofemoral pain syndrome (PFPS) are common musculoskeletal conditions associated with postural instability. However, the direction-specific nature of balance deficits and comparative patterns across these conditions remain unclear. Therefore, the aim of this study is to compare overall, mediolateral, and anteroposterior postural stability indices among individuals with LAS, PFPS, and healthy controls using the Biodex Balance System

Conditions

Ankle Sprains; Patellofemoral Pain Syndrome

Keywords

Postural stability; APSI; MLSI; OASI; LAS; PFPS

Outcome Measures

Primary Outcomes (3)

• APSI

  anterior-posterior stability index

  one shot assessment within one week

• MLSI

  Medial-lateral stability index

  one shot assessment within one week

• OASI

  overall stability index

  one shot assessment within one week

Study Arms (3)

healthy control group

30 healthy matched participants of both sexes with ages from 20 to 30 years

Diagnostic Test: diagnosis of APSI, MLSI, OASI

group of lateral ankle sprain (LAS)

30 patients with LAS of both sexes with ages from 20 to 30 years

Diagnostic Test: diagnosis of APSI, MLSI, OASI

group of patellofemoral pain syndrome (PFPS)

30 patients with PFPS of both sexes with ages from 20 to 30 years

Diagnostic Test: diagnosis of APSI, MLSI, OASI

Interventions

diagnosis of APSI, MLSI, OASI DIAGNOSTIC_TEST

To compare overall, antero-posterior and mediolateral postural stability indices among individuals with lateral ankle sprain, patellofemoral pain syndrome, and healthy controls using the Biodex Balance System.

group of lateral ankle sprain (LAS); group of patellofemoral pain syndrome (PFPS); healthy control group

Eligibility Criteria

• Age: 20 Years - 30 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

a total of 90 participants (30 per group) will be required to participate in the study taking into consideration 10% drop out. Participants of both sexes with ages of 20 to 30 years will be recruited and assigned into three groups: individuals with lateral ankle sprain (LAS), individuals with patellofemoral pain syndrome (PFPS), and healthy control participants. All participants will have normal cognitive function and the ability to understand and follow instructions required for balance assessment.

Sponsors & Collaborators

• Cairo University: lead

MeSH Terms

Conditions

Ankle Injuries; Patellofemoral Pain Syndrome

Condition Hierarchy (Ancestors)

Leg Injuries; Wounds and Injuries; Joint Diseases; Musculoskeletal Diseases

Study Officials

• Azza Abdelmohsen, professor

  Cairo University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Azza M Abdelmohsen, professor

CONTACT

01145046304; dr_azzamohammed@yahoo.com

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: professor

Study Record Dates

• First Submitted: March 27, 2026
• First Posted: April 2, 2026
• Study Start: March 30, 2026
• Primary Completion: April 25, 2026
• Study Completion: April 27, 2026
• Last Updated: April 9, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will not share