Comparing Effects of HIIT and MICT on Functional Mobility, Muscle Strength, and Quality of Life in Diabetic Patients

NCT07484399 | Not Yet Recruiting

• 1 other identifier: REC/RCR & AHS/24/02110
• Study Type: interventional
• Target: 28
• Locations: 0 countries
• Sites: N/A

Brief Summary

To compare the effects of High-Intensity Interval Training (HIIT) and Moderate-Intensity Continuous Training (MICT) on functional mobility, muscle strength, and quality of life in individuals with type-2-diabetes.

Conditions

Type 2 Diabetes Mellitus With Complication

Keywords

muscles weakness, disability, reduced quality of life,

Outcome Measures

Primary Outcomes (5)

• TUG timed up go test

  Functional mobility is evaluated by the TUG test. The TUG test has revealed very high test-retest reliability among patients with diabetes, as shown by the ICC values from 0.93 to 0.99

  baseline pre exam, 6th week of intervention, and 12th week

• Hand Grip Strength Test

  To assess the power of muscles a dynamometer used to test the gripping power of participants making an objective estimate of the strength of the muscles in the upper body. This method had the same validity as that of the whole functional capacity in diabetic populations, with coefficients of 0.70 to 0.85 being most common

  baseline pre exam, 6th week of intervention, and 12th week

• Chair Stand Test

  In order to evaluate again the strength of the lower limb muscles. The individuals were measured how fast they could stand up from a chair and sit down again and again, which is an indicator of muscle endurance and functional strength. The test has shown really high reliability in diabetic populations with ICC values being around 0.85 to 0.91.

  baseline pre exam, 6th week of intervention, and 12th week

• The Borg 6-20 Scale

  The Borg 6-20 scale used to measure the rate of perceived exertion. It has a strong relationship with heart rate and oxygen consumption with the range of correlation coefficients between 0.80 and 0.88 for diabetic individuals. The Borg RPE scale in T2DM has a test-retest reliability indicated by the Intraclass Correlation Coefficient (ICC) of about 0.85 to 0.92, which means that people give similar ratings of their exertion consistently across repeated sessions in similar exercise conditions

  baseline pre exam, 6th week of intervention, and 12th week

• WHOQOL-BREF Questionnaire

  The WHOQOL-BREF is a universal instrument that measures the quality of life in different aspects such as physical health, psychological health, social relationships, and environment. In patients with diabetes, the WHOQOL-BREF reveals a strong internal consistency with Cronbach's alpha values ranging from 0.76 to 0.88

  baseline pre exam, 6th week of intervention, and 12th week

Study Arms (2)

High Intensity Interval Training

ACTIVE COMPARATOR

Warm-up: - 5 minutes of dynamic stretching.Exercise Intervals- 4 sets of 4 minutes high-intensity exercises (i.e, sprint intervals on a treadmill and squat jumping) - Intensity: Corresponding to perceived exertion rating (RPE) of 15-18 on the Borg 6-20 scale (32).Cool-down:- 3 minutes of active recovery intervals- Intensity: Rating of perceived exertion (RPE) 8 to 10.Schedule:- Frequency: 3 times per week- Duration: 12-week period- Total session duration: 30-32 minutesObjective:- Focus on maximizing cardiovascular and muscular adaptations through brief, intense activity bursts.

Other: High Intensity Interval Training

Moderate Intensity Continuous Training

ACTIVE COMPARATOR

Warm-up:- 5 minutes of dynamic stretching.Continuous Exercise:- 40 minutes of moderate-intensity exercises (i.e., brisk walking on a treadmill) - Intensity: Perceived exertion rate of 11-13 on the Borg 6-20 scale (34).Cool-down: None (continuous without intervals)Schedule:- Frequency: 3 times per week- Duration: 12-week period- Total session duration: 45 minutesObjective:- Promote endurance and quality of life with a sustainable approach to improving overall physical endurance.

Other: Moderate Intensity Continuous Training

Interventions

High Intensity Interval Training OTHER

3 session per week, 12 weeks sessions continued, each session had 4 sets of 4 minutes exercise with 3 min active rest inbetween routines. total 30 minutes per session, Sprinting and Jump squatting RPE 15-18

High Intensity Interval Training

Moderate Intensity Continuous Training OTHER

3 session per week, 12 weeks sessions continued, 40 minutes one single exercise regime with no intervals. Brisk Walking on Treadmill, RPE-11-13

Moderate Intensity Continuous Training

Eligibility Criteria

• Age: 35 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• :• Adults aging form 35 to 65.
• Both male and female diabetic patients.
• Individuals diagnosed with type 2 diabetes for at least five years.
• Individuals able to participate in moderate to intense physical activity.

You may not qualify if:

• Individuals with significant orthopedic limitations.
• Individuals with uncontrolled cardiovascular disease or musculoskeletal issues.
• Individuals with incontinence issues during physical activity or inability to comply to study protocols

Sponsors & Collaborators

• Riphah International University: lead

MeSH Terms

Interventions

High-Intensity Interval Training

Intervention Hierarchy (Ancestors)

Physical Conditioning, Human; Exercise; Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Sobia Kanwal, tDPT

  Riphah International University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Imran Amjad, Phd.

CONTACT

03324390125; imran.amjad@riphah.edu.pk

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Masking Details: It was a single blinded study, the assessor was blind
• Purpose: SUPPORTIVE CARE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 16, 2026
• First Posted: March 20, 2026
• Study Start: March 5, 2026
• Primary Completion (Estimated): July 17, 2026
• Study Completion (Estimated): September 22, 2026
• Last Updated: March 20, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will not share