Silent Threat: Impact of Preoperative Albumin Levels on Outcomes in Geriatric Cancer Surgery

NCT06998030 | Completed

• 1 other identifier: 2025-03/53
• Study Type: observational
• Target: 330
• Locations: 1 country
• Sites: 1

Brief Summary

This retrospective, single-center study aims to evaluate the impact of preoperative albumin levels on postoperative outcomes in geriatric patients (aged 65 and above) undergoing cancer surgery. The study will compare postoperative complication rates, length of hospital stay, and intensive care needs between patients with hypoalbuminemia and those with normal albumin levels.

Conditions

Neoplasms; Aged; Hypoalbuminemia; Malnutrition; Postoperative Complications

Outcome Measures

Primary Outcomes (1)

• Postoperative Complication Rate

  The proportion of patients experiencing any postoperative complication (including but not limited to pulmonary complications, infections, or other adverse events) within 30 days after surgery, as assessed by clinical records and standardized criteria (e.g., Clavien-Dindo classification)

  within 30 days after surgery

Secondary Outcomes (5)

• Length of Hospital Stay

  postoperative first 30 days

• Postoperative Intensive Care Unit (ICU) Admission

  immediately after the surgery

• Length of ICU Stay

  30 days after surgery

• 30-day Postoperative Mortality

  within 30 days after surgery

• Incidence of Specific Postoperative Pulmonary Complications

  30 days after surgery

Study Arms (2)

Group 1 (<3.5 g/dL, hypoalbuminemia)

Participants with preoperative serum albumin levels less than 3.5 g/dL. This group represents geriatric cancer surgery patients who are considered to have hypoalbuminemia, indicating poor nutritional and/or inflammatory status prior to surgery.

Group 2 (≥3.5 g/dL, normal)

Participants with preoperative serum albumin levels equal to or greater than 3.5 g/dL. This group represents geriatric cancer surgery patients with normal preoperative albumin levels, reflecting adequate nutritional and inflammatory status prior to surgery.

Eligibility Criteria

• Age: 65 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

This study will include geriatric patients aged 65 years and older who underwent elective cancer surgery at Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital. All participants must have a documented preoperative serum albumin level. Patients with emergency or palliative surgery, active infection or inflammatory disease, or missing/incomplete medical records will be excluded. The study population represents a real-world cohort of elderly cancer patients at increased risk for postoperative complications due to age-related physiological changes and comorbidities.

You may qualify if:

• Age 65 years or older
• Diagnosed with cancer and underwent cancer surgery
• Preoperative albumin level recorded before surgery

You may not qualify if:

• Preoperative sepsis, severe infection, or active inflammatory disease
• Emergency or palliative surgery
• Missing preoperative albumin value
• Incomplete medical records or follow-up data

Sponsors & Collaborators

• Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital: lead

Study Sites (1)

Dr. Abdurrahman Yurtaslan Ankara Oncology Education and Research Hospital Clinic of Anesthesiology and Reanimation

Ankara, Yenimahalle, 06200, Turkey (Türkiye)

Location

Related Publications (4)

• Song S, Qiu P, Wang H, Zhang D, Qi Q, Feng L. Low preoperative serum prealbumin levels and risk of postoperative complications after transsphenoidal surgery in nonfunctioning pituitary adenoma. Neurosurg Focus. 2022 Dec;53(6):E6. doi: 10.3171/2022.9.FOCUS22211.

  PMID: 36455266 BACKGROUND

• Caras RJ, Lustik MB, Kern SQ, McMann LP, Sterbis JR. Preoperative Albumin Is Predictive of Early Postoperative Morbidity and Mortality in Common Urologic Oncologic Surgeries. Clin Genitourin Cancer. 2017 Apr;15(2):e255-e262. doi: 10.1016/j.clgc.2016.09.008. Epub 2016 Sep 23.

  PMID: 27765612 BACKGROUND

• Loftus TJ, Brown MP, Slish JH, Rosenthal MD. Serum Levels of Prealbumin and Albumin for Preoperative Risk Stratification. Nutr Clin Pract. 2019 Jun;34(3):340-348. doi: 10.1002/ncp.10271. Epub 2019 Mar 25.

  PMID: 30908744 BACKGROUND

• Heise D, Bednarsch J, Kroh A, Schipper S, Eickhoff R, Lang S, Neumann U, Ulmer F. Operative Time, Age, and Serum Albumin Predict Surgical Morbidity After Laparoscopic Liver Surgery. Surg Innov. 2021 Dec;28(6):714-722. doi: 10.1177/1553350621991223. Epub 2021 Feb 10.

  PMID: 33568020 BACKGROUND

MeSH Terms

Conditions

Neoplasms; Hypoalbuminemia; Postoperative Complications; Malnutrition

Condition Hierarchy (Ancestors)

Hypoproteinemia; Blood Protein Disorders; Hematologic Diseases; Hemic and Lymphatic Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Nutrition Disorders; Nutritional and Metabolic Diseases

Study Officials

• Mustafa Kemal SAHIN

  MUSTAFA KEMAL SAHİN

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: M.D

Study Record Dates

• First Submitted: May 13, 2025
• First Posted: May 31, 2025
• Study Start: April 1, 2025
• Primary Completion: April 30, 2025
• Study Completion: May 10, 2025
• Last Updated: April 30, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)