Relationship Between Albumin/Creatine Ratio, B12, Folate, and Frailty Index

NCT06393647 | Recruiting

• 1 other identifier: AnkaraEtlikYusufOzguner007
• Study Type: observational
• Target: 40
• Locations: 1 country
• Sites: 2

Brief Summary

In the literature, the relationship between frailty and various blood tests such as beta-2 microglobulin, CRP, procalcitonin, vitamin D, IL-1, and IL-6 has been investigated (2). In our study, the investigators aim to investigate the relationship between frailty status assessed using frailty scale forms (Frailty Scale Version 9, Quality of Life Scale Short Form-36) and preoperative levels of Albumin/Creatinine, B12, Folate, Ferritin, hemogram, Sedimentation Rate, and CRP in patients undergoing gastrointestinal malignancy surgery. By identifying the relationship among these parameters, the investigators believe that modifiable factors contributing to frailty in patients at risk can be addressed through appropriate interventions.

Conditions

Frailty

Keywords

Frailty Scale; Albumin/Creatine Ratio; B12; Folate

Outcome Measures

Primary Outcomes (2)

• Frailty Scale Version 9

  Patients' frailty status will be assessed using the Frailty Scale Version 9.There are scores between 1 and 9 on this scale. Patients with a score of 4 or above are defined as fraile.

  one day before surgery

• Quality of Life Scale Short Form-36

  SF-36 is a scale to be used to evaluate quality of life.In this scoring, scoring is between 0-100. Increasing scores are considered as positive health status.

  one day before surgery

Secondary Outcomes (3)

• Albumin/Creatine Ratio

  one day before surgery

• B12 levels

  one day before surgery

• Folate levels

  one day before surgery

Study Arms (2)

Frail group

In our study, we aim to investigate the relationship between frailty status assessed using frailty scale forms (Frailty Scale Version 9, Quality of Life Scale Short Form-36) and preoperative levels of Albumin/Creatinine, B12, Folate, Ferritin, Hemogram, Sedimentation Rate, and CRP in patients undergoing gastrointestinal malignancy surgery.

Other: Frailty scale forms (Frailty Scale Version 9, Quality of Life Scale Short Form-36)

Non-frail group

In our study, we aim to investigate the relationship between frailty status assessed using frailty scale forms (Frailty Scale Version 9, Quality of Life Scale Short Form-36) and preoperative levels of Albumin/Creatinine, B12, Folate, Ferritin, Hemogram, Sedimentation Rate, and CRP in patients undergoing gastrointestinal malignancy surgery.

Other: Frailty scale forms (Frailty Scale Version 9, Quality of Life Scale Short Form-36)

Interventions

Frailty scale forms (Frailty Scale Version 9, Quality of Life Scale Short Form-36) OTHER

In our study, we aim to investigate the relationship between frailty status assessed using frailty scale forms (Frailty Scale Version 9, Quality of Life Scale Short Form-36) and preoperative levels of Albumin/Creatinine, B12, Folate, Ferritin, Sedimentation Rate, and CRP in patients undergoing gastrointestinal malignancy surgery.

Frail group; Non-frail group

Eligibility Criteria

• Age: 65 Years - 90 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

In our study, we aim to investigate the relationship between frailty status assessed using frailty scale forms (Frailty Scale Version 9, Quality of Life Scale Short Form-36) and preoperative levels of Albumin/Creatine, B12, Folate, Ferritin, Sedimentation Rate, and CRP in patients undergoing gastrointestinal malignancy surgery.

You may qualify if:

• Patients who are over 65 years old.
• Patients classified under ASA (American Society of Anesthesiologists) risk groups I, II, and III.
• Patients with gastrointestinal malignancy undergoing surgery

You may not qualify if:

• Patients who are under 65 years old.
• Patients with an ASA score of IV or higher.
• Patients who refuse to participate in the study.
• Patients undergoing emergency surgeries will be excluded from the study

Sponsors & Collaborators

• Ankara Etlik City Hospital: lead

Study Sites (2)

Yusuf

Çankaya, Ankara, Turkey (Türkiye)

RECRUITING

Ankara Etlik City Hospital

Ankara, Varlık Mahallesi, Halil Sezai Erkut Caddesi Yenimahalle, 06170, Turkey (Türkiye)

RECRUITING

Related Publications (2)

• Kim M, Suzuki T, Kojima N, Yoshida H, Yoshida Y, Hirano H, Won CW, Kim H. Association Between Serum beta2 -Microglobulin Levels and Prevalent and Incident Physical Frailty in Community-Dwelling Older Women. J Am Geriatr Soc. 2017 Apr;65(4):e83-e88. doi: 10.1111/jgs.14733. Epub 2017 Jan 31.

  PMID: 28140452 BACKGROUND

• Shamliyan T, Talley KM, Ramakrishnan R, Kane RL. Association of frailty with survival: a systematic literature review. Ageing Res Rev. 2013 Mar;12(2):719-36. doi: 10.1016/j.arr.2012.03.001. Epub 2012 Mar 12.

  PMID: 22426304 RESULT

MeSH Terms

Conditions

Frailty

Condition Hierarchy (Ancestors)

Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Target Duration: 1 Week
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: April 27, 2024
• First Posted: May 1, 2024
• Study Start: June 15, 2024
• Primary Completion: October 15, 2024
• Study Completion: November 5, 2024
• Last Updated: July 31, 2024

Record last verified: 2024-07

Locations

TU (2)