Frailty and Nottingham Hip Fracture Score for Predicting 90-Day Mortality After Hip Fracture Surgery

NCT07481188 | Recruiting

• 1 other identifier: TÜTF-GOBAEK 2026/81
• Study Type: observational
• Target: 200
• Locations: 1 country
• Sites: 1

Brief Summary

Hip fractures are serious injuries that occur mostly in older adults. Many people experience health problems or may die in the months after surgery. Doctors try to identify patients who have a higher risk of poor outcomes as early as possible. Doctors often use the Nottingham Hip Fracture Score (NHFS) to estimate the risk of death after hip fracture surgery. This score uses information such as age and other health conditions. However, it does not fully reflect how physically vulnerable a person may be. Another important concept is frailty. Frailty describes how strong or weak a person's overall health and physical reserve are. In this study, frailty will be measured using the Clinical Frailty Scale (CFS). This scale evaluates a person's level of independence and physical function before the fracture. The purpose of this study is to determine whether measuring frailty can improve the prediction of death after hip fracture surgery. Older adults with hip fractures who undergo surgery will be invited to participate in the study. Researchers plan to include about 200 participants or all eligible patients enrolled within one year, whichever occurs first. Health information that is already collected during routine hospital care will be recorded. Frailty will be assessed when participants are admitted to the hospital. Participants will be followed for 30 days and 90 days after surgery to determine survival status. Researchers will review hospital records and may contact participants or their relatives by phone if needed. The results of this study may help doctors better identify patients at higher risk and improve care planning after hip fracture surgery.

Conditions

Hip Fracture; Proximal Femur Fracture; Frailty

Keywords

Hip fracture; Proximal femur fracture; Frailty; Geriatric fracture; Mortality prediction

Outcome Measures

Primary Outcomes (1)

• 90 Day All Cause Mortality

  All cause mortality occurring within 90 days after hip fracture surgery.

  90 days after surgery

Secondary Outcomes (3)

• 30 Day All Cause Mortality

  30 days after surgery

• Postoperative complications

  90 days after surgery

• Length of hospital stay

  From hospital admission to hospital discharge (up to 30 days)

Study Arms (1)

Hip Fracture Surgery Cohort

Older adults aged 60 years or older who undergo surgical treatment for proximal femoral fractures. Frailty will be assessed using the Clinical Frailty Scale and mortality outcomes will be evaluated at 30 and 90 days after surgery.

Other: No Intervention: Observational Cohort

Interventions

No Intervention: Observational Cohort OTHER

no intervention

Hip Fracture Surgery Cohort

Eligibility Criteria

• Age: 60 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Older adults admitted with proximal femoral fractures who undergo surgical treatment at Trakya University Hospital.

You may qualify if:

• Age 60 years or older
• Admission for acute proximal femoral fracture (femoral neck, intertrochanteric, or subtrochanteric fracture)
• Surgical treatment for hip fracture
• Ability to obtain clinical data required for NHFS and frailty assessment

You may not qualify if:

• Pathological fractures
• Periprosthetic fractures
• Hip fractures resulting from high-energy trauma or polytrauma
• Non-operative treatment
• Second hip fracture occurring in the same patient during the study period

Sponsors & Collaborators

• Trakya University: lead

Study Sites (1)

Trakya University

Edirne, Turkey (Türkiye)

RECRUITING

Related Publications (3)

• Maxwell MJ, Moran CG, Moppett IK. Development and validation of a preoperative scoring system to predict 30 day mortality in patients undergoing hip fracture surgery. Br J Anaesth. 2008 Oct;101(4):511-7. doi: 10.1093/bja/aen236. Epub 2008 Aug 21.

  PMID: 18723517 BACKGROUND

• Narula S,Lawless A,D'Alessandro P,Jones CW,Yates P,Seymour H

  BACKGROUND

• Kennedy MJ,Penfold RS,Donaldson L,Hall AJ,Davison MJ,MacLullich AMJ,Walmsley P,Clement ND,Clarke JV

  BACKGROUND

MeSH Terms

Conditions

Hip Fractures; Proximal Femoral Fractures; Frailty

Condition Hierarchy (Ancestors)

Femoral Fractures; Fractures, Bone; Wounds and Injuries; Hip Injuries; Leg Injuries; Femoral Neck Fractures; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Central Study Contacts

Eşref SELÇUK Asst Prof, MD

CONTACT

+905356319974; trkesref@hotmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: March 11, 2026
• First Posted: March 18, 2026
• Study Start: March 15, 2026
• Primary Completion (Estimated): March 15, 2027
• Study Completion (Estimated): March 15, 2027
• Last Updated: March 31, 2026

Record last verified: 2026-03

Locations

TU (1)